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Chemical Compound Review

AGN-PC-00AIJ3     icosa-5,8,11,14-tetraenoic acid

Synonyms: AG-B-56765, AG-F-70356, AG-H-11197, KBioGR_000259, KBioGR_001370, ...
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Disease relevance of arachidonic acid


Psychiatry related information on arachidonic acid


High impact information on arachidonic acid


Chemical compound and disease context of arachidonic acid


Biological context of arachidonic acid


Anatomical context of arachidonic acid


Associations of arachidonic acid with other chemical compounds


Gene context of arachidonic acid

  • We show that cPLA2 selectively cleaves arachidonic acid from natural membrane vesicles and demonstrate that cPLA2 translocates to membrane vesicles in response to physiologically relevant changes in free calcium [34].
  • Mice lacking COX-2 have normal inflammatory responses to treatments with tetradecanoyl phorbol acetate or with arachidonic acid [35].
  • Cyclooxygenase (COX), first purified in 1976 and cloned in 1988, is the key enzyme in the synthesis of prostaglandins (PGs) from arachidonic acid [36].
  • Lipopolysaccharides prime whole human blood and isolated neutrophils for the increased synthesis of 5-lipoxygenase products by enhancing arachidonic acid availability: involvement of the CD14 antigen [37].
  • These eicosanoids, formed by cyclooxygenase-dependent metabolism of arachidonic acid, are important physiologic mediators of renal glomerular hemodynamics and tubular sodium and water reabsorption [38].

Analytical, diagnostic and therapeutic context of arachidonic acid


  1. Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin. Bokoch, G.M., Gilman, A.G. Cell (1984) [Pubmed]
  2. The effects of ibuprofen on the physiology and survival of patients with sepsis. The Ibuprofen in Sepsis Study Group. Bernard, G.R., Wheeler, A.P., Russell, J.A., Schein, R., Summer, W.R., Steinberg, K.P., Fulkerson, W.J., Wright, P.E., Christman, B.W., Dupont, W.D., Higgins, S.B., Swindell, B.B. N. Engl. J. Med. (1997) [Pubmed]
  3. Mediators of immediate hypersensitivity derived from arachidonic acid. Goetzl, E.J. N. Engl. J. Med. (1980) [Pubmed]
  4. Deposition of terminal C5b-9 complement complexes on erythrocytes and leukocytes during cardiopulmonary bypass. Salama, A., Hugo, F., Heinrich, D., Höge, R., Müller, R., Kiefel, V., Mueller-Eckhardt, C., Bhakdi, S. N. Engl. J. Med. (1988) [Pubmed]
  5. The effects of a 5-lipoxygenase inhibitor on asthma induced by cold, dry air. Israel, E., Dermarkarian, R., Rosenberg, M., Sperling, R., Taylor, G., Rubin, P., Drazen, J.M. N. Engl. J. Med. (1990) [Pubmed]
  6. Do lithium and anticonvulsants target the brain arachidonic acid cascade in bipolar disorder? Rapoport, S.I., Bosetti, F. Arch. Gen. Psychiatry (2002) [Pubmed]
  7. Short-term administration of omega 3 fatty acids from fish oil results in increased transthyretin transcription in old rat hippocampus. Puskás, L.G., Kitajka, K., Nyakas, C., Barcelo-Coblijn, G., Farkas, T. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  8. Elevated central nervous system prostaglandins in human immunodeficiency virus-associated dementia. Griffin, D.E., Wesselingh, S.L., McArthur, J.C. Ann. Neurol. (1994) [Pubmed]
  9. Reduced arachidonate in serum phospholipids and cholesteryl esters associated with vegetarian diets in humans. Phinney, S.D., Odin, R.S., Johnson, S.B., Holman, R.T. Am. J. Clin. Nutr. (1990) [Pubmed]
  10. Plasma phospholipid essential fatty acids and prostaglandins in alcoholic, habitually violent, and impulsive offenders. Virkkunen, M.E., Horrobin, D.F., Jenkins, D.K., Manku, M.S. Biol. Psychiatry (1987) [Pubmed]
  11. Chemoattractant receptors on phagocytic cells. Snyderman, R., Pike, M.C. Annu. Rev. Immunol. (1984) [Pubmed]
  12. Leukotrienes. Hammarström, S. Annu. Rev. Biochem. (1983) [Pubmed]
  13. Astrocyte control of synaptic transmission and neurovascular coupling. Haydon, P.G., Carmignoto, G. Physiol. Rev. (2006) [Pubmed]
  14. Control of aldosterone secretion: a model for convergence in cellular signaling pathways. Spät, A., Hunyady, L. Physiol. Rev. (2004) [Pubmed]
  15. P-450 metabolites of arachidonic acid in the control of cardiovascular function. Roman, R.J. Physiol. Rev. (2002) [Pubmed]
  16. Arachidonic acid induces a prolonged inhibition of glutamate uptake into glial cells. Barbour, B., Szatkowski, M., Ingledew, N., Attwell, D. Nature (1989) [Pubmed]
  17. Stimulus-dependent myristoylation of a major substrate for protein kinase C. Aderem, A.A., Albert, K.A., Keum, M.M., Wang, J.K., Greengard, P., Cohn, Z.A. Nature (1988) [Pubmed]
  18. Activation of peripheral CB1 cannabinoid receptors in haemorrhagic shock. Wagner, J.A., Varga, K., Ellis, E.F., Rzigalinski, B.A., Martin, B.R., Kunos, G. Nature (1997) [Pubmed]
  19. Benoxaprofen suppression of polychlorinated biphenyl toxicity without alteration of mixed function oxidase function. Rifkind, A.B., Muschick, H. Nature (1983) [Pubmed]
  20. Flurbiprofen: a potent inhibitor of alveolar bone resorption in beagles. Williams, R.C., Jeffcoat, M.K., Kaplan, M.L., Goldhaber, P., Johnson, H.G., Wechter, W.J. Science (1985) [Pubmed]
  21. Luteolysis: a neuroendocrine-mediated event. McCracken, J.A., Custer, E.E., Lamsa, J.C. Physiol. Rev. (1999) [Pubmed]
  22. Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration. Langenbach, R., Morham, S.G., Tiano, H.F., Loftin, C.D., Ghanayem, B.I., Chulada, P.C., Mahler, J.F., Lee, C.A., Goulding, E.H., Kluckman, K.D., Kim, H.S., Smithies, O. Cell (1995) [Pubmed]
  23. cPLA2 is phosphorylated and activated by MAP kinase. Lin, L.L., Wartmann, M., Lin, A.Y., Knopf, J.L., Seth, A., Davis, R.J. Cell (1993) [Pubmed]
  24. Epidermal growth factor-induced actin remodeling is regulated by 5-lipoxygenase and cyclooxygenase products. Peppelenbosch, M.P., Tertoolen, L.G., Hage, W.J., de Laat, S.W. Cell (1993) [Pubmed]
  25. Transmethylation reactions regulate affinity and functional activity of chemotactic factor receptors on macrophages. Pike, M.C., Snyderman, R. Cell (1982) [Pubmed]
  26. Regulation of histamine-mediated prostacyclin synthesis in cultured human vascular endothelial cells. Baenziger, N.L., Fogerty, F.J., Mertz, L.F., Chernuta, L.F. Cell (1981) [Pubmed]
  27. Thromboxane A2 in vasotonic angina pectoris: evidence from direct measurements and inhibitor trials. Robertson, R.M., Robertson, D., Roberts, L.J., Maas, R.L., FitzGerald, G.A., Friesinger, G.C., Oates, J.A. N. Engl. J. Med. (1981) [Pubmed]
  28. Arachidonic acid metabolites and the interactions between platelets and blood-vessel walls. Moncada, S., Vane, J.R. N. Engl. J. Med. (1979) [Pubmed]
  29. Rac mediates growth factor-induced arachidonic acid release. Peppelenbosch, M.P., Qiu, R.G., de Vries-Smits, A.M., Tertoolen, L.G., de Laat, S.W., McCormick, F., Hall, A., Symons, M.H., Bos, J.L. Cell (1995) [Pubmed]
  30. Suppression of intestinal polyposis in Apc delta716 knockout mice by inhibition of cyclooxygenase 2 (COX-2). Oshima, M., Dinchuk, J.E., Kargman, S.L., Oshima, H., Hancock, B., Kwong, E., Trzaskos, J.M., Evans, J.F., Taketo, M.M. Cell (1996) [Pubmed]
  31. Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides. Needleman, P., Moncada, S., Bunting, S., Vane, J.R., Hamberg, M., Samuelsson, B. Nature (1976) [Pubmed]
  32. Platelet-dependent stimulation of prostacyclin synthesis by platelet-derived growth factor. Coughlin, S.R., Moskowitz, M.A., Zetter, B.R., Antoniades, H.N., Levine, L. Nature (1980) [Pubmed]
  33. The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Ricote, M., Li, A.C., Willson, T.M., Kelly, C.J., Glass, C.K. Nature (1998) [Pubmed]
  34. A novel arachidonic acid-selective cytosolic PLA2 contains a Ca(2+)-dependent translocation domain with homology to PKC and GAP. Clark, J.D., Lin, L.L., Kriz, R.W., Ramesha, C.S., Sultzman, L.A., Lin, A.Y., Milona, N., Knopf, J.L. Cell (1991) [Pubmed]
  35. Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse. Morham, S.G., Langenbach, R., Loftin, C.D., Tiano, H.F., Vouloumanos, N., Jennette, J.C., Mahler, J.F., Kluckman, K.D., Ledford, A., Lee, C.A., Smithies, O. Cell (1995) [Pubmed]
  36. Cyclooxygenases 1 and 2. Vane, J.R., Bakhle, Y.S., Botting, R.M. Annu. Rev. Pharmacol. Toxicol. (1998) [Pubmed]
  37. Lipopolysaccharides prime whole human blood and isolated neutrophils for the increased synthesis of 5-lipoxygenase products by enhancing arachidonic acid availability: involvement of the CD14 antigen. Surette, M.E., Palmantier, R., Gosselin, J., Borgeat, P. J. Exp. Med. (1993) [Pubmed]
  38. Cyclooxygenase-2 is associated with the macula densa of rat kidney and increases with salt restriction. Harris, R.C., McKanna, J.A., Akai, Y., Jacobson, H.R., Dubois, R.N., Breyer, M.D. J. Clin. Invest. (1994) [Pubmed]
  39. Release of prostaglandin D2 into human airways during acute antigen challenge. Murray, J.J., Tonnel, A.B., Brash, A.R., Roberts, L.J., Gosset, P., Workman, R., Capron, A., Oates, J.A. N. Engl. J. Med. (1986) [Pubmed]
  40. Leukotriene production in human neutrophils primed by recombinant human granulocyte/macrophage colony-stimulating factor and stimulated with the complement component C5A and FMLP as second signals. Dahinden, C.A., Zingg, J., Maly, F.E., de Weck, A.L. J. Exp. Med. (1988) [Pubmed]
  41. Release of arachidonic acid from human lymphocytes in response to mitogenic lectins. Parker, C.W., Kelly, J.P., Falkenhein, S.F., Huber, M.G. J. Exp. Med. (1979) [Pubmed]
  42. Prevention of diabetes in the BB rat by essential fatty acid deficiency. Relationship between physiological and biochemical changes. Lefkowith, J., Schreiner, G., Cormier, J., Handler, E.S., Driscoll, H.K., Greiner, D., Mordes, J.P., Rossini, A.A. J. Exp. Med. (1990) [Pubmed]
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