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Chemical Compound Review

AGN-PC-004OF1     7-[3-hydroxy-2-(3-hydroxyoct- 1-enyl)-5-oxo...

Synonyms: AG-E-02025, SureCN1504288, CTK0H0560, AC1L18LU, 154170-57-7, ...
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Disease relevance of Dinoprostone


Psychiatry related information on Dinoprostone


High impact information on Dinoprostone


Chemical compound and disease context of Dinoprostone


Biological context of Dinoprostone

  • PGE2, a chief cyclooxygenase product, modulates blood pressure and fertility, although the specific G protein-coupled receptors mediating these effects remain poorly defined [19].
  • Inactivation of EGFR kinase with selective inhibitors significantly reduces PGE2-induced ERK2 activation, c-fos mRNA expression and cell proliferation [3].
  • Since it has been observed that IL-2 inhibits the catalytic activity of adenylate cyclase and that agents such as PGE2 which stimulate adenylate cyclase activity inhibit the lymphoproliferative response to IL-2, association of GTP binding proteins with IL-2 signal transduction was investigated [20].
  • In chromaffin cells, two different second messenger pathways are activated by PGE2 binding to an apparently single EP3 receptor class [21].
  • As the airway epithelium is morphologically similar and also expresses one of these receptors, PAR2, and is a major source of PGE2, we reasoned that bronchial epithelial PAR2 might also participate in prostanoid-dependent cytoprotection in the airways [22].

Anatomical context of Dinoprostone


Associations of Dinoprostone with other chemical compounds


Gene context of Dinoprostone

  • To evaluate the physiologic role of the PGE2 EP2 receptor subtype, we created mice with targeted disruption of this gene (EP2-/-) [19].
  • Native human IL-1 beta and IL-1 alpha stimulated prostaglandin E2 secretion by human embryonic lung fibroblasts at half-maximal concentrations of 3 +/- 1.2 pM (+/- SEM) and 10 +/- 2.3 pM, respectively [33].
  • Comparison of the biological response curves and binding curves obtained for IL-1 alpha and IL-1 beta showed that they were parallel and that 10-15% occupancy of the estimated 3,000 sites by either species of IL-1 was sufficient to give half-maximal stimulation of prostaglandin E2 secretion [33].
  • 3LL tumor cells constitutively express cyclooxygenase (COX)-1 and COX-2 and produce high levels of PGE2 [34].
  • In contrast, prostaglandins E1 and E2 (PGE1 and PGE2) suppressed IL-2 production [35].

Analytical, diagnostic and therapeutic context of Dinoprostone


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  9. Prostaglandin E2 and its methyl ester reduce cataplexy in canine narcolepsy. Nishino, S., Mignot, E., Fruhstorfer, B., Dement, W.C., Hayaishi, O. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  10. Astrocyte control of synaptic transmission and neurovascular coupling. Haydon, P.G., Carmignoto, G. Physiol. Rev. (2006) [Pubmed]
  11. Induction of labor compared with expectant management for prelabor rupture of the membranes at term. TERMPROM Study Group. Hannah, M.E., Ohlsson, A., Farine, D., Hewson, S.A., Hodnett, E.D., Myhr, T.L., Wang, E.E., Weston, J.A., Willan, A.R. N. Engl. J. Med. (1996) [Pubmed]
  12. Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration. Langenbach, R., Morham, S.G., Tiano, H.F., Loftin, C.D., Ghanayem, B.I., Chulada, P.C., Mahler, J.F., Lee, C.A., Goulding, E.H., Kluckman, K.D., Kim, H.S., Smithies, O. Cell (1995) [Pubmed]
  13. A comparison of intravaginal misoprostol with prostaglandin E2 for termination of second-trimester pregnancy. Jain, J.K., Mishell, D.R. N. Engl. J. Med. (1994) [Pubmed]
  14. Prostacyclin-IP signaling and prostaglandin E2-EP2/EP4 signaling both mediate joint inflammation in mouse collagen-induced arthritis. Honda, T., Segi-Nishida, E., Miyachi, Y., Narumiya, S. J. Exp. Med. (2006) [Pubmed]
  15. Effects of endogenously produced leukotrienes, thromboxane, and prostaglandins on coronary vascular resistance in rabbit myocardial infarction. Evers, A.S., Murphree, S., Saffitz, J.E., Jakschik, B.A., Needleman, P. J. Clin. Invest. (1985) [Pubmed]
  16. Identification of the mechanism for the inhibition of Na+,K(+)-adenosine triphosphatase by hyperglycemia involving activation of protein kinase C and cytosolic phospholipase A2. Xia, P., Kramer, R.M., King, G.L. J. Clin. Invest. (1995) [Pubmed]
  17. Bleomycin-induced pulmonary fibrosis in hamsters. An alveolar macrophage product increases fibroblast prostaglandin E2 and cyclic adenosine monophosphate and suppresses fibroblast proliferation and collagen production. Clark, J.G., Kostal, K.M., Marino, B.A. J. Clin. Invest. (1983) [Pubmed]
  18. Prostaglandin E2 inhibits sodium transport in rabbit cortical collecting duct by increasing intracellular calcium. Hébert, R.L., Jacobson, H.R., Breyer, M.D. J. Clin. Invest. (1991) [Pubmed]
  19. Salt-sensitive hypertension and reduced fertility in mice lacking the prostaglandin EP2 receptor. Kennedy, C.R., Zhang, Y., Brandon, S., Guan, Y., Coffee, K., Funk, C.D., Magnuson, M.A., Oates, J.A., Breyer, M.D., Breyer, R.M. Nat. Med. (1999) [Pubmed]
  20. Stimulation of specific GTP binding and hydrolysis activities in lymphocyte membrane by interleukin-2. Evans, S.W., Beckner, S.K., Farrar, W.L. Nature (1987) [Pubmed]
  21. Alternative splicing of C-terminal tail of prostaglandin E receptor subtype EP3 determines G-protein specificity. Namba, T., Sugimoto, Y., Negishi, M., Irie, A., Ushikubi, F., Kakizuka, A., Ito, S., Ichikawa, A., Narumiya, S. Nature (1993) [Pubmed]
  22. A protective role for protease-activated receptors in the airways. Cocks, T.M., Fong, B., Chow, J.M., Anderson, G.P., Frauman, A.G., Goldie, R.G., Henry, P.J., Carr, M.J., Hamilton, J.R., Moffatt, J.D. Nature (1999) [Pubmed]
  23. Furosemide promotes patent ductus arteriosus in premature infants with the respiratory-distress syndrome. Green, T.P., Thompson, T.R., Johnson, D.E., Lock, J.E. N. Engl. J. Med. (1983) [Pubmed]
  24. Stimulation of muscle protein degradation and prostaglandin E2 release by leukocytic pyrogen (interleukin-1). A mechanism for the increased degradation of muscle proteins during fever. Baracos, V., Rodemann, H.P., Dinarello, C.A., Goldberg, A.L. N. Engl. J. Med. (1983) [Pubmed]
  25. Uptake of apoptotic cells drives the growth of a pathogenic trypanosome in macrophages. Freire-de-Lima, C.G., Nascimento, D.O., Soares, M.B., Bozza, P.T., Castro-Faria-Neto, H.C., de Mello, F.G., DosReis, G.A., Lopes, M.F. Nature (2000) [Pubmed]
  26. Role of PGE2 in anion exchange in gastric mucosa. Durbin, R.P. Nature (1980) [Pubmed]
  27. Vitamin E modulates the lipoxygenation of arachidonic acid in leukocytes. Goetzl, E.J. Nature (1980) [Pubmed]
  28. The antihypertensive effects of fish oil. A controlled study of polyunsaturated fatty acid supplements in essential hypertension. Knapp, H.R., FitzGerald, G.A. N. Engl. J. Med. (1989) [Pubmed]
  29. Biosynthesis of prostacyclin in rat liver endothelial cells and its control by prostaglandin E2. Tomasi, V., Meringolo, C., Bartolini, G., Orlandi, M. Nature (1978) [Pubmed]
  30. Prostaglandins mediate inhibition of gastric acid secretion by somatostatin in the rat. Ligumsky, M., Goto, Y., Debas, H., Yamada, T. Science (1983) [Pubmed]
  31. Plasmodium falciparum produces prostaglandins that are pyrogenic, somnogenic, and immunosuppressive substances in humans. Kilunga Kubata, B., Eguchi, N., Urade, Y., Yamashita, K., Mitamura, T., Tai, K., Hayaishi, O., Horii, T. J. Exp. Med. (1998) [Pubmed]
  32. Monocytes regulate osteoclast-activating factor production by releasing prostaglandins. Yoneda, T., Mundy, G.R. J. Exp. Med. (1979) [Pubmed]
  33. Identification of a high-affinity receptor for native human interleukin 1 beta and interleukin 1 alpha on normal human lung fibroblasts. Chin, J., Cameron, P.M., Rupp, E., Schmidt, J.A. J. Exp. Med. (1987) [Pubmed]
  34. Arginase I in myeloid suppressor cells is induced by COX-2 in lung carcinoma. Rodriguez, P.C., Hernandez, C.P., Quiceno, D., Dubinett, S.M., Zabaleta, J., Ochoa, J.B., Gilbert, J., Ochoa, A.C. J. Exp. Med. (2005) [Pubmed]
  35. Immune dysfunction in diabetes-prone BB rats. Interleukin 2 production and other mitogen-induced responses are suppressed by activated macrophages. Prud'homme, G.J., Fuks, A., Colle, E., Seemayer, T.A., Guttmann, R.D. J. Exp. Med. (1984) [Pubmed]
  36. Reversible acute renal failure induced by indomethacin. Tan, S.Y., Shapiro, R., Kish, M.A. JAMA (1979) [Pubmed]
  37. Antihemostatic, antiinflammatory, and immunosuppressive properties of the saliva of a tick, Ixodes dammini. Ribeiro, J.M., Makoul, G.T., Levine, J., Robinson, D.R., Spielman, A. J. Exp. Med. (1985) [Pubmed]
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