Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Leucoanthocyanidins 2-phenylchroman-3,4-diol

Synonyms: AC1NSXIS, SureCN170331, CHEBI:60835, CTK1H2518, 5023-02-9, ...

Nakajima , J. et al., Wilmouth, R.C. et al., Shimada, S. et al.

Wilmouth, Turnbull, Welford, Clifton, Prescott, Schofield,

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Disease relevance of Leucoanthocyanidin

Recombinant Spinacia and Phytolacca DFRs expressed in Escherichia coli convert dihydroflavonol to leucoanthocyanidin [1].

High impact information on Leucoanthocyanidin

Here we show that recombinant ANSs from several model plant species, snapdragon, petunia, torenia, and maize, catalyze the formation of anthocyanidin in vitro through a 2-oxoglutarate-dependent oxidation of leucoanthocyanidin [2].
Together with in vitro studies, the crystal structures suggest a mechanism for ANS-catalyzed anthocyanidin formation from the natural leucoanthocyanidin substrates involving stereoselective C-3 hydroxylation [3].

References

Dihydroflavonol 4-reductase cDNA from non-anthocyanin-producing species in the Caryophyllales. Shimada, S., Takahashi, K., Sato, Y., Sakuta, M. Plant Cell Physiol. (2004) [Pubmed]
Reaction mechanism from leucoanthocyanidin to anthocyanidin 3-glucoside, a key reaction for coloring in anthocyanin biosynthesis. Nakajima , J., Tanaka, Y., Yamazaki, M., Saito, K. J. Biol. Chem. (2001) [Pubmed]
Structure and mechanism of anthocyanidin synthase from Arabidopsis thaliana. Wilmouth, R.C., Turnbull, J.J., Welford, R.W., Clifton, I.J., Prescott, A.G., Schofield, C.J. Structure (Camb.) (2002) [Pubmed]

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