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Chemical Compound Review

Oxoglutarate     2-oxopentanedioic acid

Synonyms: CHEMBL1686, AGN-PC-00AXX2, ACMC-1BMR3, AG-F-17404, CHEBI:30915, ...
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Disease relevance of alpha-Oxoglutaric acid


Psychiatry related information on alpha-Oxoglutaric acid


High impact information on alpha-Oxoglutaric acid


Chemical compound and disease context of alpha-Oxoglutaric acid


Biological context of alpha-Oxoglutaric acid


Anatomical context of alpha-Oxoglutaric acid


Associations of alpha-Oxoglutaric acid with other chemical compounds


Gene context of alpha-Oxoglutaric acid


Analytical, diagnostic and therapeutic context of alpha-Oxoglutaric acid


  1. Antibodies against mitochondrial dehydrogenase complexes in primary biliary cirrhosis. Yoshida, T., Bonkovsky, H., Ansari, A., Danner, D. Gastroenterology (1990) [Pubmed]
  2. Signal transduction to the Azotobacter vinelandii NIFL-NIFA regulatory system is influenced directly by interaction with 2-oxoglutarate and the PII regulatory protein. Little, R., Reyes-Ramirez, F., Zhang, Y., van Heeswijk, W.C., Dixon, R. EMBO J. (2000) [Pubmed]
  3. Escherichia coli kgtP encodes an alpha-ketoglutarate transporter. Seol, W., Shatkin, A.J. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  4. Transcriptional activation of NtcA-dependent promoters of Synechococcus sp. PCC 7942 by 2-oxoglutarate in vitro. Tanigawa, R., Shirokane, M., Maeda Si, S., Omata, T., Tanaka, K., Takahashi, H. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  5. DOOR syndrome (deafness, onycho-osteodystrophy, and mental retardation): elevated plasma and urinary 2-oxoglutarate in three unrelated patients. Patton, M.A., Krywawych, S., Winter, R.M., Brenton, D.P., Baraitser, M. Am. J. Med. Genet. (1987) [Pubmed]
  6. Ornithine alpha-ketoglutarate supplementation influences motor activity in healthy rats. Moinard, C., Dauge, V., Cynober, L. Clinical nutrition (Edinburgh, Scotland) (2004) [Pubmed]
  7. Structural insights into histone demethylation by JMJD2 family members. Chen, Z., Zang, J., Whetstine, J., Hong, X., Davrazou, F., Kutateladze, T.G., Simpson, M., Mao, Q., Pan, C.H., Dai, S., Hagman, J., Hansen, K., Shi, Y., Zhang, G. Cell (2006) [Pubmed]
  8. Mutant deoxynucleotide carrier is associated with congenital microcephaly. Rosenberg, M.J., Agarwala, R., Bouffard, G., Davis, J., Fiermonte, G., Hilliard, M.S., Koch, T., Kalikin, L.M., Makalowska, I., Morton, D.H., Petty, E.M., Weber, J.L., Palmieri, F., Kelley, R.I., Schäffer, A.A., Biesecker, L.G. Nat. Genet. (2002) [Pubmed]
  9. Folding in vivo of bacterial cytoplasmic proteins: role of GroEL. Horwich, A.L., Low, K.B., Fenton, W.A., Hirshfield, I.N., Furtak, K. Cell (1993) [Pubmed]
  10. Alpha-ketoglutarate for myocardial protection in heart surgery. Kjellman, U., Björk, K., Ekroth, R., Karlsson, H., Jagenburg, R., Nilsson, F., Svensson, G., Wernerman, J. Lancet (1995) [Pubmed]
  11. Human ABH3 structure and key residues for oxidative demethylation to reverse DNA/RNA damage. Sundheim, O., Vågbø, C.B., Bjørås, M., Sousa, M.M., Talstad, V., Aas, P.A., Drabløs, F., Krokan, H.E., Tainer, J.A., Slupphaug, G. EMBO J. (2006) [Pubmed]
  12. Global carbon/nitrogen control by PII signal transduction in cyanobacteria: from signals to targets. Forchhammer, K. FEMS Microbiol. Rev. (2004) [Pubmed]
  13. Phylogeny of the bacterial superfamily of Crp-Fnr transcription regulators: exploiting the metabolic spectrum by controlling alternative gene programs. Körner, H., Sofia, H.J., Zumft, W.G. FEMS Microbiol. Rev. (2003) [Pubmed]
  14. Structure-function analysis of phytanoyl-CoA 2-hydroxylase mutations causing Refsum's disease. Mukherji, M., Chien, W., Kershaw, N.J., Clifton, I.J., Schofield, C.J., Wierzbicki, A.S., Lloyd, M.D. Hum. Mol. Genet. (2001) [Pubmed]
  15. Phosphorylation inactivates Escherichia coli isocitrate dehydrogenase by preventing isocitrate binding. Dean, A.M., Lee, M.H., Koshland, D.E. J. Biol. Chem. (1989) [Pubmed]
  16. Reduction of collagen production in keloid fibroblast cultures by ethyl-3,4-dihydroxybenzoate. Inhibition of prolyl hydroxylase activity as a mechanism of action. Sasaki, T., Majamaa, K., Uitto, J. J. Biol. Chem. (1987) [Pubmed]
  17. Characterization of the iron- and 2-oxoglutarate-binding sites of human prolyl 4-hydroxylase. Myllyharju, J., Kivirikko, K.I. EMBO J. (1997) [Pubmed]
  18. Gene duplication in the diversification of secondary metabolism: tandem 2-oxoglutarate-dependent dioxygenases control glucosinolate biosynthesis in Arabidopsis. Kliebenstein, D.J., Lambrix, V.M., Reichelt, M., Gershenzon, J., Mitchell-Olds, T. Plant Cell (2001) [Pubmed]
  19. Abiotic Stress Generates ROS That Signal Expression of Anionic Glutamate Dehydrogenases to Form Glutamate for Proline Synthesis in Tobacco and Grapevine. Skopelitis, D.S., Paranychianakis, N.V., Paschalidis, K.A., Pliakonis, E.D., Delis, I.D., Yakoumakis, D.I., Kouvarakis, A., Papadakis, A.K., Stephanou, E.G., Roubelakis-Angelakis, K.A. Plant Cell (2006) [Pubmed]
  20. Nonmetabolizable analogue of 2-oxoglutarate elicits heterocyst differentiation under repressive conditions in Anabaena sp. PCC 7120. Laurent, S., Chen, H., Bédu, S., Ziarelli, F., Peng, L., Zhang, C.C. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  21. Transport of tricarboxylic acid cycle intermediates by membrane vesicles from renal brush border. Kippen, I., Hirayama, B., Klinenberg, J.R., Wright, E.M. Proc. Natl. Acad. Sci. U.S.A. (1979) [Pubmed]
  22. Hydroxylation of aspartic acid in domains homologous to the epidermal growth factor precursor is catalyzed by a 2-oxoglutarate-dependent dioxygenase. Stenflo, J., Holme, E., Lindstedt, S., Chandramouli, N., Huang, L.H., Tam, J.P., Merrifield, R.B. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  23. Knockout of Slc25a19 causes mitochondrial thiamine pyrophosphate depletion, embryonic lethality, CNS malformations, and anemia. Lindhurst, M.J., Fiermonte, G., Song, S., Struys, E., De Leonardis, F., Schwartzberg, P.L., Chen, A., Castegna, A., Verhoeven, N., Mathews, C.K., Palmieri, F., Biesecker, L.G. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  24. Sensitivity of the 2-oxoglutarate carrier to alcohol intake contributes to mitochondrial glutathione depletion. Coll, O., Colell, A., García-Ruiz, C., Kaplowitz, N., Fernández-Checa, J.C. Hepatology (2003) [Pubmed]
  25. Direct spectroscopic detection of a C-H-cleaving high-spin Fe(IV) complex in a prolyl-4-hydroxylase. Hoffart, L.M., Barr, E.W., Guyer, R.B., Bollinger, J.M., Krebs, C. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  26. Prolyl hydroxylase half reaction: peptidyl prolyl-independent decarboxylation of alpha-ketoglutarate. Counts, D.F., Cardinale, G.J., Udenfriend, S. Proc. Natl. Acad. Sci. U.S.A. (1978) [Pubmed]
  27. A fully active catalytic domain of bovine aspartyl (asparaginyl) beta-hydroxylase expressed in Escherichia coli: characterization and evidence for the identification of an active-site region in vertebrate alpha-ketoglutarate-dependent dioxygenases. Jia, S., McGinnis, K., VanDusen, W.J., Burke, C.J., Kuo, A., Griffin, P.R., Sardana, M.K., Elliston, K.O., Stern, A.M., Friedman, P.A. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  28. The reaction of fluorocitrate with aconitase and the crystal structure of the enzyme-inhibitor complex. Lauble, H., Kennedy, M.C., Emptage, M.H., Beinert, H., Stout, C.D. Proc. Natl. Acad. Sci. U.S.A. (1996) [Pubmed]
  29. Regulation of intracellular free calcium concentration during heterocyst differentiation by HetR and NtcA in Anabaena sp. PCC 7120. Shi, Y., Zhao, W., Zhang, W., Ye, Z., Zhao, J. Proc. Natl. Acad. Sci. U.S.A. (2006) [Pubmed]
  30. Escherichia coli alpha-ketoglutarate permease is a constitutively expressed proton symporter. Seol, W., Shatkin, A.J. J. Biol. Chem. (1992) [Pubmed]
  31. Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases. Koivunen, P., Hirsilä, M., Günzler, V., Kivirikko, K.I., Myllyharju, J. J. Biol. Chem. (2004) [Pubmed]
  32. Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways. Elvidge, G.P., Glenny, L., Appelhoff, R.J., Ratcliffe, P.J., Ragoussis, J., Gleadle, J.M. J. Biol. Chem. (2006) [Pubmed]
  33. Sources of NADPH and expression of mammalian NADP+-specific isocitrate dehydrogenases in Saccharomyces cerevisiae. Minard, K.I., Jennings, G.T., Loftus, T.M., Xuan, D., McAlister-Henn, L. J. Biol. Chem. (1998) [Pubmed]
  34. AlkB-mediated oxidative demethylation reverses DNA damage in Escherichia coli. Falnes, P.Ø., Johansen, R.F., Seeberg, E. Nature (2002) [Pubmed]
  35. Declines in mitochondrial respiration during cardiac reperfusion: age-dependent inactivation of alpha-ketoglutarate dehydrogenase. Lucas, D.T., Szweda, L.I. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  36. Identification and analysis of the major M2 autoantigens in primary biliary cirrhosis. Fussey, S.P., Guest, J.R., James, O.F., Bassendine, M.F., Yeaman, S.J. Proc. Natl. Acad. Sci. U.S.A. (1988) [Pubmed]
  37. Epitope mapping and reactivity of autoantibodies to the E2 component of 2-oxoglutarate dehydrogenase complex in primary biliary cirrhosis using recombinant 2-oxoglutarate dehydrogenase complex. Moteki, S., Leung, P.S., Dickson, E.R., Van Thiel, D.H., Galperin, C., Buch, T., Alarcon-Segovia, D., Kershenobich, D., Kawano, K., Coppel, R.L. Hepatology (1996) [Pubmed]
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