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Chemical Compound Review:

Tyrphostin B48 (E)-2-cyano-3-(3,4- dihydroxyphenyl)-N...

Synonyms: Lopac-T-4318, Tocris-0619, CHEMBL56731, AG-494, SureCN5909179, ...

Osherov, N. et al., Lapidos, K.A. et al., Kang, J.L. et al.

Kang, Go, Hur, Castranova,

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Disease relevance of Tyrphostin B48

The Mg(++)-stimulated chemotaxis was inhibited > 60% by pertussis toxin, d-erythrosphingosine, and tyrphostin B48, but unaffected by cholera toxin exposure [1].

High impact information on Tyrphostin B48

Tyrphostin AG 494 blocks Cdk2 activation [2].
Yet, AG 494 proved to inhibit EGF- or serum-induced cell proliferation (Osherov et al., J. Biol. Chem. 268 (1993) 11134-11142) [2].
AG 494 and its analogs may become useful lead compounds for the development of drugs aimed at the cell cycle machinery [2].
Genistein and AG-494 also reduced NF-kappaB activation in H2O2-treated cells [3].

References

Mg(++)-induced endothelial cell migration: substratum selectivity and receptor-involvement. Lapidos, K.A., Woodhouse, E.C., Kohn, E.C., Masiero, L. Angiogenesis (2001) [Pubmed]
Tyrphostin AG 494 blocks Cdk2 activation. Osherov, N., Levitzki, A. FEBS Lett. (1997) [Pubmed]
Silica-induced nuclear factor-kappaB activation: involvement of reactive oxygen species and protein tyrosine kinase activation. Kang, J.L., Go, Y.H., Hur, K.C., Castranova, V. J. Toxicol. Environ. Health Part A (2000) [Pubmed]

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