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Chemical Compound Review:

Zinacef sodium(6R,7S)-3- (aminocarbonyloxymethyl)...

Synonyms:

Irshaid, Y.M. et al., Alfter, G. et al., Marcos Bravo, C. et al.

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Disease relevance of Cephuroxime

A 60-year-old man developed an anaphylactic reaction immediately after administration of intramuscular sodium cefuroxime [1].

High impact information on Cephuroxime

The pharmacokinetic parameters (AUC0-8h, AUC0-infinity, Cmax, tmax, t1/2, Ke) of cefuroxime following a single intramuscular injection of 750 mg of a test product (Maxil, Hikma Pharmaceuticals, Amman, Jordan) were compared to those of a reference product (Zinacef, Glaxo, UK) [2].

Analytical, diagnostic and therapeutic context of Cephuroxime

Serum and tissue samples were taken, to determine the intraoperative cefuroxime concentration, from 40 patients who had been given 1.5 g cefuroxime (Zinacef) i.v. during maxillofacial surgery [3].

References

Hypersensitivity to cefuroxime with good tolerance to other betalactams. Marcos Bravo, C., Luna Ortiz, I., González Vázquez, R. Allergy (1995) [Pubmed]
Comparative pharmacokinetics of 2 brands of cefuroxime following a single intramuscular injection. Irshaid, Y.M., Rawashdeh, N.M., Zghol, F., Jalal, I., Najib, N.M. International journal of clinical pharmacology and therapeutics. (1995) [Pubmed]
Perioperative antibiotic prophylaxis with cefuroxime in oral-maxillofacial surgical procedures. Alfter, G., Schwenzer, N., Friess, D., Möhrle, E. Journal of cranio-maxillo-facial surgery : official publication of the European Association for Cranio-Maxillo-Facial Surgery. (1995) [Pubmed]

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