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Disease relevance of Anaphylaxis


Psychiatry related information on Anaphylaxis

  • The clinical outcome--the intensity of the reaction--is not only influenced by the degree of sensitization, but also by concomitant other factors: sometimes, individuals only develop anaphylaxis after simultaneous exposure to the allergen and an infection, physical exercise, psychological stress or concomitant medication (e.g. beta blockers) [6].
  • Knowledge and perceived self-efficacy of participants were measured before and after the training program to determine if a theory-based anaphylaxis recognition and epinephrine auto-injector training program would increase participants' knowledge and self-efficacy in responding to an anaphylactic emergency [7].

High impact information on Anaphylaxis


Chemical compound and disease context of Anaphylaxis


Biological context of Anaphylaxis


Anatomical context of Anaphylaxis

  • In addition, a factor chemotactic for human eosinophils with the size and charge characteristics of the eosinophil chemotactic factor of anaphylaxis was identified in blullous fluid [21].
  • Effects of chronic treatment with the c-kit ligand, stem cell factor, on immunoglobulin E-dependent anaphylaxis in mice. Genetically mast cell-deficient Sl/Sld mice acquire anaphylactic responsiveness, but the congenic normal mice do not exhibit augmented responses [22].
  • Histamine, slow reacting substance of anaphylaxis (S.R.S.-A), IgE, eosinophils, and an eosinophil-associated enzyme, arylsulphatase IIB, were measured in sputum from 11 chronic bronchitics at weekly intervals for 6 weeks [23].
  • By using anti-IgE antibody treatments and mice with targeted mutations of the FcgammaRIII alpha-chain or the common gamma-chain of FcepsilonRI and FcgammaRI/III, we demonstrate that IgE crosslinking of FcepsilonRI appears to be necessary and sufficient for myelin peptide-induced anaphylaxis [24].
  • Release of slow reacting substance of anaphylaxis (SRS-A) from human leukocytes by the calcium ionophore A23187 [25].

Gene context of Anaphylaxis

  • As has been shown with conventional antibodies, monoclonal IgG1 and IgE are the two classes capable of sensitizing the mouse for anaphylactic reactions, IgE sensitizes the rat, and IgG2a sensitizes the guinea pig [26].
  • These 5LO(-/-) mice were unable to synthesize detectable levels of leukotrienes and were more resistant to lethal anaphylaxis induced by platelet-activating factor [27].
  • Vav1-deficient mice contain normal numbers of mast cells but respond more weakly than their normal counterparts to a passive systemic anaphylaxis challenge [28].
  • IL-4 exacerbates anaphylaxis [29].
  • Pretreatment of mice with IL-4 or the related cytokine, IL-13, rapidly and dramatically increased the severity of anaphylaxis induced by cross-linking Fc(epsilon)RI or FcgammaRIII [29].

Analytical, diagnostic and therapeutic context of Anaphylaxis


  1. Cold urticaria: release into the circulation of histamine and eosinophil chemotactic factor of anaphylaxis during cold challenge. Soter, N.A., Wasserman, S.I., Austen, K.F. N. Engl. J. Med. (1976) [Pubmed]
  2. Tryptase levels as an indicator of mast-cell activation in systemic anaphylaxis and mastocytosis. Schwartz, L.B., Metcalfe, D.D., Miller, J.S., Earl, H., Sullivan, T. N. Engl. J. Med. (1987) [Pubmed]
  3. Slow-reacting substances (leukotrienes) contract human airway and pulmonary vascular smooth muscle in vitro. Hanna, C.J., Bach, M.K., Pare, P.D., Schellenberg, R.R. Nature (1981) [Pubmed]
  4. Alteration of leukotriene D4 hypotension by thyrotropin releasing hormone. Lux, W.E., Feuerstein, G., Faden, A.I. Nature (1983) [Pubmed]
  5. Impaired IgG-dependent anaphylaxis and Arthus reaction in Fc gamma RIII (CD16) deficient mice. Hazenbos, W.L., Gessner, J.E., Hofhuis, F.M., Kuipers, H., Meyer, D., Heijnen, I.A., Schmidt, R.E., Sandor, M., Capel, P.J., Daëron, M., van de Winkel, J.G., Verbeek, J.S. Immunity (1996) [Pubmed]
  6. History and classification of anaphylaxis. Ring, J., Brockow, K., Behrendt, H. Novartis Found. Symp. (2004) [Pubmed]
  7. Evaluation of an anaphylaxis training program for unlicensed assistive personnel. Litarowsky, J.A., Murphy, S.O., Canham, D.L. The Journal of school nursing : the official publication of the National Association of School Nurses. (2004) [Pubmed]
  8. Anaphylaxis from the carboxymethylcellulose component of barium sulfate suspension. Klein, J.S. N. Engl. J. Med. (1998) [Pubmed]
  9. Anaphylactic reaction to latex gloves. Wolf, B.L. N. Engl. J. Med. (1993) [Pubmed]
  10. Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor alpha chain gene. Dombrowicz, D., Flamand, V., Brigman, K.K., Koller, B.H., Kinet, J.P. Cell (1993) [Pubmed]
  11. Anaphylactic reaction to gonadotropin-releasing hormone. Potashnik, G., Lunenfeld, E., Spitz, E., Glezerman, M. N. Engl. J. Med. (1993) [Pubmed]
  12. Kunitz soybean trypsin inhibitor: a specific allergen in food anaphylaxis. Moroz, L.A., Yang, W.H. N. Engl. J. Med. (1980) [Pubmed]
  13. Apparent anaphylactic reaction to zomepirac (Zomax). Samuel, S.A. N. Engl. J. Med. (1981) [Pubmed]
  14. Anaphylactic reaction to intravenous cyclosporine. Chapuis, B., Helg, C., Jeannet, M., Zulian, G., Huber, P., Gumovski, P. N. Engl. J. Med. (1985) [Pubmed]
  15. Anaphylaxis from tolmetin. Ahmad, S. N. Engl. J. Med. (1980) [Pubmed]
  16. Time course of appearance and disappearance of human mast cell tryptase in the circulation after anaphylaxis. Schwartz, L.B., Yunginger, J.W., Miller, J., Bokhari, R., Dull, D. J. Clin. Invest. (1989) [Pubmed]
  17. Allergy treatment with a peptide vaccine. Stanworth, D.R., Jones, V.M., Lewin, I.V., Nayyar, S. Lancet (1990) [Pubmed]
  18. Effect of myeloma IgE injections on passive and active cutaneous anaphylaxis in rats. Spiegelberg, H.L., Canning, K.M., Scheetz, M., Koppel, G., Chiller, J.M. J. Immunol. (1986) [Pubmed]
  19. Cell-specific regulation of expression of plasma-type platelet-activating factor acetylhydrolase in the liver. Howard, K.M., Miller, J.E., Miwa, M., Olson, M.S. J. Biol. Chem. (1997) [Pubmed]
  20. Leukotriene C4 binding to rat lung membranes. Pong, S.S., DeHaven, R.N., Kuehl, F.A., Egan, R.W. J. Biol. Chem. (1983) [Pubmed]
  21. Morphologic and functional evidence for release of mast-cell products in bullous pemphigoid. Wintroub, B.U., Mihm, M.C., Goetzl, E.J., Soter, N.A., Austen, K.F. N. Engl. J. Med. (1978) [Pubmed]
  22. Effects of chronic treatment with the c-kit ligand, stem cell factor, on immunoglobulin E-dependent anaphylaxis in mice. Genetically mast cell-deficient Sl/Sld mice acquire anaphylactic responsiveness, but the congenic normal mice do not exhibit augmented responses. Ando, A., Martin, T.R., Galli, S.J. J. Clin. Invest. (1993) [Pubmed]
  23. Variations in chemical mediators of hypersensitivity in the sputum of chronic bronchitics: correlation with peak expiratory flow. Turnbull, L.W., Turnbull, L.S., Crofton, J., Kay, A.B. Lancet (1978) [Pubmed]
  24. Differential induction of IgE-mediated anaphylaxis after soluble vs. cell-bound tolerogenic peptide therapy of autoimmune encephalomyelitis. Smith, C.E., Eagar, T.N., Strominger, J.L., Miller, S.D. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  25. Release of slow reacting substance of anaphylaxis (SRS-A) from human leukocytes by the calcium ionophore A23187. Conroy, M.C., Orange, R.P., Lichtenstein, L.M. J. Immunol. (1976) [Pubmed]
  26. Biological activities of antitrinitrophenyl and antidinitrophenyl mouse monoclonal antibodies. Hirayama, N., Hirano, T., Köhler, G., Kurata, A., Okumura, K., Ovary, Z. Proc. Natl. Acad. Sci. U.S.A. (1982) [Pubmed]
  27. Altered inflammatory responses in leukotriene-deficient mice. Goulet, J.L., Snouwaert, J.N., Latour, A.M., Coffman, T.M., Koller, B.H. Proc. Natl. Acad. Sci. U.S.A. (1994) [Pubmed]
  28. Vav1 regulates phospholipase cgamma activation and calcium responses in mast cells. Manetz, T.S., Gonzalez-Espinosa, C., Arudchandran, R., Xirasagar, S., Tybulewicz, V., Rivera, J. Mol. Cell. Biol. (2001) [Pubmed]
  29. IL-4 exacerbates anaphylaxis. Strait, R.T., Morris, S.C., Smiley, K., Urban, J.F., Finkelman, F.D. J. Immunol. (2003) [Pubmed]
  30. An assessment of the safety of pediatric ibuprofen. A practitioner-based randomized clinical trial. Lesko, S.M., Mitchell, A.A. JAMA (1995) [Pubmed]
  31. Cardiac disorders in penicillin-induced anaphylaxis. Association with intravenous epinephrine therapy. Sullivan, T.J. JAMA (1982) [Pubmed]
  32. IgG-blocking antibodies inhibit IgE-mediated anaphylaxis in vivo through both antigen interception and Fc gamma RIIb cross-linking. Strait, R.T., Morris, S.C., Finkelman, F.D. J. Clin. Invest. (2006) [Pubmed]
  33. Mast cell protease release and mucosal ultrastructure during intestinal anaphylaxis in the rat. Patrick, M.K., Dunn, I.J., Buret, A., Miller, H.R., Huntley, J.F., Gibson, S., Gall, D.G. Gastroenterology (1988) [Pubmed]
  34. Engineering of the major house dust mite allergen Der f 2 for allergen-specific immunotherapy. Takai, T., Yokota, T., Yasue, M., Nishiyama, C., Yuuki, T., Mori, A., Okudaira, H., Okumura, Y. Nat. Biotechnol. (1997) [Pubmed]
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