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Chemical Compound Review:

SureCN935274 4-(5-amino-6-benzyl-1H- pyrazin-2...

Synonyms: AF-350, Oprea1_099028, AC1NTC7P, KB-34565, AF 350, ...

Burton, M. et al., Dubuisson, M.L. et al., He, G.S. et al., Janssens, B.J. et al.

Janssens, Marchand-Brynaert, Rees, He, Lin, Dai, Prasad, Kannan, Dombroskie, Vaia, Tan,

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High impact information on Coelenteramine

Coelenterazine (2-p-hydroxybenzyl-6-(3'-hydroxyphenyl)-8-benzyl-3,7-dihydroimidazolo[1,2-a]pyrazin-3-one, CLZn) and coelenteramine (2-amino-3-benzyl-5-(4'-hydroxyphenyl)-1,4-pyrazine, CLM), first described as luciferin and etioluciferin, respectively, of bioluminescent systems in marine organisms are endowed with antioxidant properties [1].
CLZn's oxidation product coelenteramine (CLM) also delayed the lysis of the cells as well as the occurrence of oxidative stress indicators but it did not offer protection against DNA damage [2].
Recent work showed that CLZn, its synthetic analogue CLZm, and their common oxidation product coelenteramine (CLM) have strong antioxidative properties in acellular lipid peroxidation systems as well as in rat hepatocytes subjected to tert-butyl hydroperoxide (t-BHP) [3].
At high excitation intensity levels (>or=15 GW/cm(2)), the saturation behavior of TPA transition can be observed obviously in AF-350 and AF-380 solutions that exhibit much higher nonlinear absorptivity than the other chromophores investigated [4].

References

Synthesis, structure-activity relationship and in vitro evaluation of coelenterazine and coelenteramine derivatives as inhibitors of lipid peroxidation. Burton, M., De Tollenaere, C., Cavalier, J.F., Marchand, C., Dussart, F., Marchand-Brynaert, J., Rees, J.F. Free Radic. Res. (2003) [Pubmed]
Protection of peroxide-treated fish erythrocytes by coelenterazine and coelenteramine. Janssens, B.J., Marchand-Brynaert, J., Rees, J.F. Free Radic. Res. (2002) [Pubmed]
Protection against nitrofurantoin-induced oxidative stress by coelenterazine analogues and their oxidation products in rat hepatocytes. Dubuisson, M.L., De Wergifosse, B., Kremers, P., Marchand-Brynaert, J., Trouet, A., Rees, J.F. Free Radic. Res. (2001) [Pubmed]
Degenerate two-photon-absorption spectral studies of highly two-photon active organic chromophores. He, G.S., Lin, T.C., Dai, J., Prasad, P.N., Kannan, R., Dombroskie, A.G., Vaia, R.A., Tan, L.S. The Journal of chemical physics. (2004) [Pubmed]

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