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Chemical Compound Review

Firefly luciferin     (2E,4R)-2-(6-oxobenzothiazol- 2-ylidene)-1...

Synonyms: Luciferin, D-Luciferin, AC1NUNCB, CHEMBL443738, CHEBI:17165, ...
 
 
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Disease relevance of Firefly luciferin

  • Both Cypridina luciferin analog-dependent chemiluminescence and luminol-dependent chemiluminescence were significantly decreased in neutrophils from patients with chronic liver disease (hepatocellular carcinoma < cirrhosis < chronic active hepatitis) when they were compared with normal healthy subjects [1].
  • The activities of antioxidant enzymes and of luciferase in the prothorax (bright) and abdomen (dim) of luminous larval Pyrearinus termitilluminans (Coleoptera: Elateridae) were measured after previous challenge with either hyperoxia, hypoxia, or the firefly luciferase inhibitor luciferin 6'-methyl ether (LME) [2].
  • An intensified charge coupled device video camera was used to noninvasively image luciferase-expressing human prostate tumors and metastases in nude mice, after ip inoculation of luciferin [3].
  • The bioluminescent reaction of adenosine 5'-triphosphate (ATP) with luciferin and luciferase has been used in conjunction with a sensitive photometer (Lab-Line's ATP photometer) to detect significant bacteriuria in urine [4].
  • Overexpression of the apoaequorin cDNA in E. coli now provides the means of obtaining gram quantities of a single isotype of the protein which can be converted to aequorin in the presence of coelenterate luciferin, oxygen and an appropriate thiol [5].
 

Psychiatry related information on Firefly luciferin

 

High impact information on Firefly luciferin

 

Chemical compound and disease context of Firefly luciferin

 

Biological context of Firefly luciferin

  • Cell viability was measured on the basis of lactate dehydrogenase release, and ATP was quantitated with a luciferin/luciferase assay [13].
  • Furthermore, there were significant positive correlations between albumin/prothrombin time and Cypridina luciferin analog-dependent chemiluminescence/luminol-dependent chemiluminescence [1].
  • Local and systemic induction of two defense-related subtilisin-like protease promoters in transgenic Arabidopsis plants. Luciferin induction of PR gene expression [14].
  • Also, we report that luciferin, the substrate for the reporter luciferase (LUC) gene, is able to activate expression of PR genes, and this may pose a problem when using this gene reporter system in studies related to plant defense [14].
  • These criteria included determination of the efficiency of infection/transfection of various viral and nonviral delivery systems, promoter specificity, and visualization of luciferase activity, and of the ability of luciferin to reach various organs [15].
 

Anatomical context of Firefly luciferin

  • We measured ATP flow (using the luciferin/luciferase method) through these channels after reconstitution into planar phospholipid membranes [16].
  • At a substrate concentration of 0.01 mM, the peak luminescence from the cos cells expressing luciferase was up to 6-fold greater with the esters than with unmodified luciferin [17].
  • Several measures of energy conservation, namely ADP/O ratio, P/O ratio, ATP/O ratio and phosphorylation detected by continuous assay with purified firefly luciferase and luciferin, all show phosphorylation can occur with mung-bean mitochondria at cyanide concentrations sufficient to inhibit the cytochrome oxidase system [18].
  • Single isolated rat hepatocytes were injected with the ATP-dependent luminescent protein firefly luciferase, and then superfused with 45 microM luciferin in air-equilibrated medium [19].
  • The atractyloside-insensitive accumulation of adenine nucleotides by rat liver mitochondria (as opposed to the exchange-diffusion catalysed by the adenine nucleotide translocase) has been measured by using the luciferin/luciferase assay as well as by measuring [14C]ATP uptake [20].
 

Associations of Firefly luciferin with other chemical compounds

 

Gene context of Firefly luciferin

 

Analytical, diagnostic and therapeutic context of Firefly luciferin

References

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  3. Combined noninvasive imaging and luminometric quantification of luciferase-labeled human prostate tumors and metastases. El Hilali, N., Rubio, N., Martinez-Villacampa, M., Blanco, J. Lab. Invest. (2002) [Pubmed]
  4. Evaluation of an adenosine 5'-triphosphate assay as a screening method to detect significant bacteriuria. Alexander, D.N., Ederer, G.M., Matsen, J.M. J. Clin. Microbiol. (1976) [Pubmed]
  5. The enzymology and molecular biology of the Ca2+-activated photoprotein, aequorin. Cormier, M.J., Prasher, D.C., Longiaru, M., McCann, R.O. Photochem. Photobiol. (1989) [Pubmed]
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  8. Can coelenterates make coelenterazine? Dietary requirement for luciferin in cnidarian bioluminescence. Haddock, S.H., Rivers, T.J., Robison, B.H. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
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  10. Cloning and expression of cDNA for the luciferase from the marine ostracod Vargula hilgendorfii. Thompson, E.M., Nagata, S., Tsuji, F.I. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  11. Extraction of Renilla-type luciferin from the calcium-activated photoproteins aequorin, mnemiopsin, and berovin. Ward, W.W., Cormier, M.J. Proc. Natl. Acad. Sci. U.S.A. (1975) [Pubmed]
  12. Cytotoxicity of chloroacetanilide herbicide alachlor in HepG2 cells independent of CYP3A4 and CYP3A7. Miranda, S.R., Meyer, S.A. Food Chem. Toxicol. (2007) [Pubmed]
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  17. Membrane-permeable luciferin esters for assay of firefly luciferase in live intact cells. Craig, F.F., Simmonds, A.C., Watmore, D., McCapra, F., White, M.R. Biochem. J. (1991) [Pubmed]
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  20. The transport and accumulation of adenine nucleotides during mitochondrial biogenesis. Pollak, J.K., Sutton, R. Biochem. J. (1980) [Pubmed]
  21. Oxyluciferin, a luminescence product of firefly luciferase, is enzymatically regenerated into luciferin. Gomi, K., Kajiyama, N. J. Biol. Chem. (2001) [Pubmed]
  22. Effect of epalrestat, an aldose reductase inhibitor, on the generation of oxygen-derived free radicals in neutrophils from streptozotocin-induced diabetic rats. Kashima, K., Sato, N., Sato, K., Shimizu, H., Mori, M. Endocrinology (1998) [Pubmed]
  23. Synthesis of dinucleoside tetraphosphates in transfected cells by a firefly luciferase reporter gene. Murphy, G.A., McLennan, A.G. Cell. Mol. Life Sci. (2004) [Pubmed]
  24. Acute production of vascular superoxide by angiotensin II but not by catecholamines. Kawazoe, T., Kosaka, H., Yoneyama, H., Hata, Y. J. Hypertens. (2000) [Pubmed]
  25. High volume bioassays to assess CYP3A4-mediated drug interactions: induction and inhibition in a single cell line. Yueh, M.F., Kawahara, M., Raucy, J. Drug Metab. Dispos. (2005) [Pubmed]
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