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Chemical Compound Review:

tilorone 2,7-bis(2- diethylaminoethoxy)fluoren-9- one

Synonyms: Tilorona, Amiksin, Tiloronum, Amixin, Amyxin, ...

Smejkal, F. et al.

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Disease relevance of Tilorone hydrochloride

The antiviral effect of 3 derivatives of benzo(c)fluorenone against encephalomyocarditis (EMC) and vaccinia viruses in mice was compared with that of tilorone hydrochloride (THCl) [1].

High impact information on Tilorone hydrochloride

Two benzo(c)fluorenone derivatives, namely VUFB 14162 and 13431, induced in mouse sera the levels of interferon (IFN), which production kinetics and hyporeactivity phenomenon were comparable with those induced by THCl [1].

Analytical, diagnostic and therapeutic context of Tilorone hydrochloride

All 3 derivatives were effective against either virus following single-dose oral application as well as after 4-times repeated subcutaneous (s.c.) treatment, but following oral administration only the VUFB 14162 derivative exerted an antiviral effect corresponding to that of THCl [1].

References

Derivatives of benzo(c)fluorene. VI. Antiviral and interferon-inducing activities of three benzo(c)fluorenone derivatives in mice. Smejkal, F., Zelená, D., Krepelka, J., Vancurová, I. Acta Virol. (1985) [Pubmed]

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