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Chemical Compound Review

tilorone     2,7-bis(2- diethylaminoethoxy)fluoren-9- one

Synonyms: Tilorona, Amiksin, Tiloronum, Amixin, Amyxin, ...
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Disease relevance of Tilorone hydrochloride

  • The antiviral effect of 3 derivatives of benzo(c)fluorenone against encephalomyocarditis (EMC) and vaccinia viruses in mice was compared with that of tilorone hydrochloride (THCl) [1].

High impact information on Tilorone hydrochloride

  • Two benzo(c)fluorenone derivatives, namely VUFB 14162 and 13431, induced in mouse sera the levels of interferon (IFN), which production kinetics and hyporeactivity phenomenon were comparable with those induced by THCl [1].

Analytical, diagnostic and therapeutic context of Tilorone hydrochloride

  • All 3 derivatives were effective against either virus following single-dose oral application as well as after 4-times repeated subcutaneous (s.c.) treatment, but following oral administration only the VUFB 14162 derivative exerted an antiviral effect corresponding to that of THCl [1].


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