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Chemical Compound Review:

Melitine 7-[3,5-dihydroxy-6-methyl-4- (3,4,5...

Synonyms: Melitin, AC1NUQTE, LS-39511, 81944-31-2, Brucella melitensis M antigen, ...

Rose, D.R. et al., Cannat, A. et al.

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Disease relevance of Brucella melitensis M antigen

1. It discriminates the Brucella abortus A antigen from the nearly identical Brucella melitensis M antigen by forming a groove-type binding site, lined with tyrosine residues, that accommodates the rodlike A antigen but excludes the kinked structure of the M antigen, as envisioned by a model of the antigen built into the combining site [1].
There is no interstrain difference between H/Ab and L/Ab mice as regards to cutaneous hypersensitivity reactions to melitin [2].

References

Crystal structure to 2.45 A resolution of a monoclonal Fab specific for the Brucella A cell wall polysaccharide antigen. Rose, D.R., Przybylska, M., To, R.J., Kayden, C.S., Oomen, R.P., Vorberg, E., Young, N.M., Bundle, D.R. Protein Sci. (1993) [Pubmed]
Response of high and low antibody producer to Brucella. Cannat, A., Bousquet, C., Serre, A. Ann. Immunol. (Paris) (1978) [Pubmed]

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