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Chemical Compound Review:

2',4'-Dimethylbenzamil (NZ)-3,5-diamino-6-chloro-N- [[2-[(2,4...

Synonyms:

Kraut, R.P. et al., Breitbart, H. et al., Taglialatela, M. et al.

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High impact information on 2',4'-Dimethylbenzamil

Inhibitors of Na+/Ca2+ exchange, namely low Na+ medium, ouabain, and the amiloride analogs 2',4'-dimethylbenzamil, 5-(N-4-chlorobenzyl)-2',4'dimethylbenzamil, and alpha-phenylbenzamil all markedly enhanced cytolysin-mediated cytolysis [1].
2',4'-Dimethylbenzamil (DMB) dose-dependently (10-100 microM) inhibited Na(+)-dependent 45Ca2+ efflux from brain synaptosomes [2].
Certain amiloride analogues 3',4'-dichlorobenzamil 2',4'-dimethylbenzamil and alpha',2'-benzobenzamil hydrochloride (ATBB) stimulate calcium accumulation and motility by epididymal bovine spermatozoa [3].

References

The influence of calcium, sodium, and the Na+/Ca2+ antiport on susceptibility to cytolysin/perforin-mediated cytolysis. Kraut, R.P., Bose, D., Cragoe, E.J., Greenberg, A.H. J. Immunol. (1990) [Pubmed]
Na(+)-Ca2+ exchange activity in central nerve endings. II. Relationship between pharmacological blockade by amiloride analogues and dopamine release from tuberoinfundibular hypothalamic neurons. Taglialatela, M., Canzoniero, L.M., Cragoe, E.J., Di Renzo, G., Annunziato, L. Mol. Pharmacol. (1990) [Pubmed]
Stimulation of Ca2+ uptake into epididymal bull spermatozoa by analogues of amiloride. Breitbart, H., Cragoe, E.J., Lardy, H.A. Eur. J. Biochem. (1990) [Pubmed]

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