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Chemical Compound Review:

AC1NUR9I 7-[(1S,5R)-6-[[(1S)-1-[[(2S)- 2...

Synonyms: LS-173523, C27H26F3N5O5.CH4O3S

This record was replaced with 5489475.

Thadepalli, H. et al., Teng, R. et al., Mitropoulos, F.A. et al.

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Disease relevance of 7-[(1R,5S)-6-[[(1S)-1-(alanylcarbamoyl)ethyl]amino]-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid

The highest cure rate (89.3%) resulted from the administration of 40 mg of CP-116,517-27 per kg of body weight three times a day (TID) for 10 days (equivalent to 18.15 mg of active drug trovafloxacin per rat per day) [1].

High impact information on 7-[(1R,5S)-6-[[(1S)-1-(alanylcarbamoyl)ethyl]amino]-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid

In a randomized, two-way crossover study, 12 fasting subjects received two 100 mg tablets of trovafloxacin and an equivalent dose of alatrofloxacin (CP-116,517), administered by i.v. infusion over 1 h [2].

Analytical, diagnostic and therapeutic context of 7-[(1R,5S)-6-[[(1S)-1-(alanylcarbamoyl)ethyl]amino]-3-azabicyclo[3.1.0]hex-3-yl]-1-(2,4-difluorophenyl)-6-fluoro-4-oxo-1,8-naphthyridine-3-carboxylic acid

After successful resuscitation, he underwent complete right lower amputation and was treated with intravenous alatrofloxacin mesylate [3].

References

In vivo efficacy of trovafloxacin (CP-99,217), a new quinolone, in experimental intra-abdominal abscesses caused by Bacteroides fragilis and Escherichia coli. Thadepalli, H., Reddy, U., Chuah, S.K., Thadepalli, F., Malilay, C., Polzer, R.J., Hanna, N., Esfandiari, A., Brown, P., Gollapudi, S. Antimicrob. Agents Chemother. (1997) [Pubmed]
Oral bioavailability of trovafloxacin with and without food in healthy volunteers. Teng, R., Dogolo, L.C., Willavize, S.A., Friedman, H.L., Vincent, J. J. Antimicrob. Chemother. (1997) [Pubmed]
Trovafloxacin-associated leukopenia. Mitropoulos, F.A., Angood, P.B., Rabinovici, R. The Annals of pharmacotherapy. (2001) [Pubmed]

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