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MeSH Review


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Disease relevance of Resuscitation


Psychiatry related information on Resuscitation


High impact information on Resuscitation

  • Kaplan-Meier estimates of the proportions of patients who had not died or had cardiac arrest with subsequent resuscitation five years after the diagnosis of hypertrophic cardiomyopathy were 67 percent among patients with bridging and 94 percent among those without bridging (P=0.004) [9].
  • Factors that predicted survival to hospital discharge included a short interval between the arrest and arrival at the hospital, a palpable pulse on presentation, a short duration of resuscitation in the emergency department, and the administration of fewer doses of epinephrine in the emergency department [10].
  • CONCLUSIONS: These results suggest that out-of-hospital cardiac arrest among children has a very poor prognosis, especially when efforts at resuscitation continue for longer than 20 minutes and require more than two doses of epinephrine [10].
  • Of the 83 patients entered in the study over a 13-month period, 40 were randomly assigned to conservative treatment, which consisted of resuscitation with intravenous fluids, institution of nasogastric suction, and intravenous administration of antibiotics (cefuroxime, ampicillin, and metronidazole) and ranitidine [11].
  • CONCLUSIONS--This study demonstrates that ACD CPR appears to be more effective than standard CPR in a well-defined subset of victims of out-of-hospital cardiac arrest during the critical early phases of resuscitation [12].

Chemical compound and disease context of Resuscitation


Biological context of Resuscitation


Anatomical context of Resuscitation


Associations of Resuscitation with chemical compounds


Gene context of Resuscitation

  • A single dose of flutamide (25 mg/kg body weight), with or without an ER antagonist (ICI 182,780), a HO enzyme inhibitor [chromium-mesoporphyrin (CrMP)], or vehicle, was administered subcutaneously during resuscitation [30].
  • At the onset of resuscitation, rats received vehicle, flutamide (25 mg/kg body wt), flutamide in combination with estrogen receptor (ER) antagonist ICI-182,780 (3 mg/kg body wt), or ICI-182,780 alone [31].
  • Contribution of tumor necrosis factor-alpha to pulmonary cytokine expression and lung injury after hemorrhage and resuscitation [32].
  • E2 (50 mug/kg), ER-alpha agonist propyl pyrazole triol (PPT; 5 mug/kg), ER-beta agonist diarylpropiolnitrile (DPN; 5 mug/kg), or vehicle (10% DMSO) was injected subcutaneously during resuscitation [33].
  • In order to examine the role of TNF-alpha in producing acute inflammatory lung injury, we treated mice following haemorrhage and resuscitation with a TNF antagonist, composed of soluble dimeric human p80 TNF receptor linked to the Fc region of human IgG1 (sTNFR:Fc) [34].

Analytical, diagnostic and therapeutic context of Resuscitation


  1. Amiodarone for resuscitation after out-of-hospital cardiac arrest due to ventricular fibrillation. Kudenchuk, P.J., Cobb, L.A., Copass, M.K., Cummins, R.O., Doherty, A.M., Fahrenbruch, C.E., Hallstrom, A.P., Murray, W.A., Olsufka, M., Walsh, T. N. Engl. J. Med. (1999) [Pubmed]
  2. Diaspirin cross-linked hemoglobin (DCLHb) in the treatment of severe traumatic hemorrhagic shock: a randomized controlled efficacy trial. Sloan, E.P., Koenigsberg, M., Gens, D., Cipolle, M., Runge, J., Mallory, M.N., Rodman, G. JAMA (1999) [Pubmed]
  3. Effects of pegorgotein on neurologic outcome of patients with severe head injury. A multicenter, randomized controlled trial. Young, B., Runge, J.W., Waxman, K.S., Harrington, T., Wilberger, J., Muizelaar, J.P., Boddy, A., Kupiec, J.W. JAMA (1996) [Pubmed]
  4. Prediction of mortality from catastrophic burns in children. Spies, M., Herndon, D.N., Rosenblatt, J.I., Sanford, A.P., Wolf, S.E. Lancet (2003) [Pubmed]
  5. Adenosine-induced atrial arrhythmia: a prospective analysis. Strickberger, S.A., Man, K.C., Daoud, E.G., Goyal, R., Brinkman, K., Knight, B.P., Weiss, R., Bahu, M., Morady, F. Ann. Intern. Med. (1997) [Pubmed]
  6. Influence of pre-CPR conditions on EMS response times in circulatory arrest. The Cerebral Resuscitation Study Group. Mullie, A., Van Hoeyweghen, R., Quets, A. Resuscitation. (1989) [Pubmed]
  7. Decision making to cease or to continue cardiopulmonary resuscitation (CPR). The Cerebral Resuscitation Study Group. Van Hoeyweghen, R., Mullie, A., Bossaert, L. Resuscitation. (1989) [Pubmed]
  8. "Resuscitation and the decision against": draft report of the President's Commission for the Study of Ethical Problems in Medicine and Biomedical and Behavioral Research. Read, B. Health law vigil. (1982) [Pubmed]
  9. Myocardial bridging in children with hypertrophic cardiomyopathy--a risk factor for sudden death. Yetman, A.T., McCrindle, B.W., MacDonald, C., Freedom, R.M., Gow, R. N. Engl. J. Med. (1998) [Pubmed]
  10. Outcome of out-of-hospital cardiac or respiratory arrest in children. Schindler, M.B., Bohn, D., Cox, P.N., McCrindle, B.W., Jarvis, A., Edmonds, J., Barker, G. N. Engl. J. Med. (1996) [Pubmed]
  11. A randomized trial of nonoperative treatment for perforated peptic ulcer. Crofts, T.J., Park, K.G., Steele, R.J., Chung, S.S., Li, A.K. N. Engl. J. Med. (1989) [Pubmed]
  12. Evaluation of active compression-decompression CPR in victims of out-of-hospital cardiac arrest. Lurie, K.G., Shultz, J.J., Callaham, M.L., Schwab, T.M., Gisch, T., Rector, T., Frascone, R.J., Long, L. JAMA (1994) [Pubmed]
  13. 'Lactate washout' following circulatory arrest. Leavy, J.A., Weil, M.H., Rackow, E.C. JAMA (1988) [Pubmed]
  14. Nimodipine after resuscitation from out-of-hospital ventricular fibrillation. A placebo-controlled, double-blind, randomized trial. Roine, R.O., Kaste, M., Kinnunen, A., Nikki, P., Sarna, S., Kajaste, S. JAMA (1990) [Pubmed]
  15. A monoclonal antibody to the adherence-promoting leukocyte glycoprotein, CD18, reduces organ injury and improves survival from hemorrhagic shock and resuscitation in rabbits. Vedder, N.B., Winn, R.K., Rice, C.L., Chi, E.Y., Arfors, K.E., Harlan, J.M. J. Clin. Invest. (1988) [Pubmed]
  16. Randomised comparison of epinephrine and vasopressin in patients with out-of-hospital ventricular fibrillation. Lindner, K.H., Dirks, B., Strohmenger, H.U., Prengel, A.W., Lindner, I.M., Lurie, K.G. Lancet (1997) [Pubmed]
  17. Postresuscitation left ventricular systolic and diastolic dysfunction. Treatment with dobutamine. Kern, K.B., Hilwig, R.W., Berg, R.A., Rhee, K.H., Sanders, A.B., Otto, C.W., Ewy, G.A. Circulation (1997) [Pubmed]
  18. Organ blood flow and somatosensory-evoked potentials during and after cardiopulmonary resuscitation with epinephrine or phenylephrine. Schleien, C.L., Koehler, R.C., Gervais, H., Berkowitz, I.D., Dean, J.M., Michael, J.R., Rogers, M.C., Traystman, R.J. Circulation (1989) [Pubmed]
  19. Chronic resuscitation after trauma-hemorrhage and acute fluid replacement improves hepatocellular function and cardiac output. Remmers, D.E., Wang, P., Cioffi, W.G., Bland, K.I., Chaudry, I.H. Ann. Surg. (1998) [Pubmed]
  20. Small intestinal submucosa for vascular reconstruction in the presence of gastrointestinal contamination. Jernigan, T.W., Croce, M.A., Cagiannos, C., Shell, D.H., Handorf, C.R., Fabian, T.C. Ann. Surg. (2004) [Pubmed]
  21. Inhibition of tyrosine kinase signaling after trauma-hemorrhage: a novel approach for improving organ function and decreasing susceptibility to subsequent sepsis. Jarrar, D., Wang, P., Song, G.Y., Cioffi, W.G., Bland, K.I., Chaudry, I.H. Ann. Surg. (2000) [Pubmed]
  22. Immunomodulatory effects of hypertonic resuscitation on the development of lung inflammation following hemorrhagic shock. Rizoli, S.B., Kapus, A., Fan, J., Li, Y.H., Marshall, J.C., Rotstein, O.D. J. Immunol. (1998) [Pubmed]
  23. The importance of adenosine and a colloid (Dextran 40) in resuscitation of ischemically damaged canine pancreas during preservation by the two-layer method. Hiraoka, K., Kuroda, Y., Tanioka, Y., Matsumoto, S., Kim, Y., Sakai, T., Fujita, H., Hamano, M., Suzuki, Y., Ku, Y. Transplantation (1994) [Pubmed]
  24. Pentoxifylline prevention of altered hepatocyte calcium regulation during hemorrhagic shock/resuscitation. Silomon, M., Pizanis, A., Larsen, R., Rose, S. Crit. Care Med. (1998) [Pubmed]
  25. Implementation of an evidence-based "standard operating procedure" and outcome in septic shock. Kortgen, A., Niederprüm, P., Bauer, M. Crit. Care Med. (2006) [Pubmed]
  26. Intraperitoneal, but not enteric, adenosine administration improves survival after volume-controlled hemorrhagic shock in rats. Wu, X., Kentner, R., Stezoski, J., Kochanek, P.M., Jackson, E.K., Carlos, T.M., Carcillo, J., Behringer, W., Safar, P., Tisherman, S.A. Crit. Care Med. (2001) [Pubmed]
  27. Phosphatidic acid signaling mediates lung cytokine expression and lung inflammatory injury after hemorrhage in mice. Abraham, E., Bursten, S., Shenkar, R., Allbee, J., Tuder, R., Woodson, P., Guidot, D.M., Rice, G., Singer, J.W., Repine, J.E. J. Exp. Med. (1995) [Pubmed]
  28. The Burns Calculator: a simple proposed guide for fluid resuscitation. Milner, S.M., Hodgetts, T.J., Rylah, L.T. Lancet (1993) [Pubmed]
  29. Intratracheal prostacyclin for resuscitation in primary pulmonary hypertension. Haas, N.A., Schulze-Neick, I., Lange, P.E. Lancet (1995) [Pubmed]
  30. Mechanism of the salutary effects of flutamide on intestinal myeloperoxidase activity following trauma-hemorrhage: up-regulation of estrogen receptor-{beta}-dependent HO-1. Yu, H.P., Choudhry, M.A., Shimizu, T., Hsieh, Y.C., Schwacha, M.G., Yang, S., Chaudry, I.H. J. Leukoc. Biol. (2006) [Pubmed]
  31. Flutamide restores cardiac function after trauma-hemorrhage via an estrogen-dependent pathway through upregulation of PGC-1. Hsieh, Y.C., Yang, S., Choudhry, M.A., Yu, H.P., Bland, K.I., Schwacha, M.G., Chaudry, I.H. Am. J. Physiol. Heart Circ. Physiol. (2006) [Pubmed]
  32. Contribution of tumor necrosis factor-alpha to pulmonary cytokine expression and lung injury after hemorrhage and resuscitation. Abraham, E., Jesmok, G., Tuder, R., Allbee, J., Chang, Y.H. Crit. Care Med. (1995) [Pubmed]
  33. Salutary effects of estrogen receptor-beta agonist on lung injury after trauma-hemorrhage. Yu, H.P., Hsieh, Y.C., Suzuki, T., Shimizu, T., Choudhry, M.A., Schwacha, M.G., Chaudry, I.H. Am. J. Physiol. Lung Cell Mol. Physiol. (2006) [Pubmed]
  34. Effects of therapy with soluble tumour necrosis factor receptor fusion protein on pulmonary cytokine expression and lung injury following haemorrhage and resuscitation. Abraham, E., Coulson, W.F., Schwartz, M.D., Allbee, J. Clin. Exp. Immunol. (1994) [Pubmed]
  35. Blood lactate as an early predictor of outcome in paracetamol-induced acute liver failure: a cohort study. Bernal, W., Donaldson, N., Wyncoll, D., Wendon, J. Lancet (2002) [Pubmed]
  36. Lactate is an unreliable indicator of tissue hypoxia in injury or sepsis. James, J.H., Luchette, F.A., McCarter, F.D., Fischer, J.E. Lancet (1999) [Pubmed]
  37. Angiotensin II augments reflex activity of the sympathetic nervous system during cardiopulmonary resuscitation in pigs. Lindner, K.H., Prengel, A.W., Pfenninger, E.G., Lindner, I.M. Circulation (1995) [Pubmed]
  38. Calcium: limited indications, some danger. Thompson, B.M., Steuven, H.S., Tonsfeldt, D.J., Aprahamian, C., Troiano, P.F., Kastenson, G.H., Hendley, G.E., Mateer, J.R., Tucker, J.F. Circulation (1986) [Pubmed]
  39. Hemorrhage decreases macrophage inflammatory protein 2 and interleukin-6 release: a possible mechanism for increased wound infection. Angele, M.K., Knöferl, M.W., Schwacha, M.G., Ayala, A., Bland, K.I., Cioffi, W.G., Josephson, S.L., Chaudry, I.H. Ann. Surg. (1999) [Pubmed]
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