Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

AC1LBY6R 2-amino-3-(2,4,6- trihydroxyphenyl)propanoi...

Synonyms: Trihydroxyphenylalanine

Metodiewa, D. et al., Taylor, S.W. et al.

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High impact information on Trihydroxyphenylalanine

A novel polypeptide containing the unusual posttranslationally modified amino acids L-3,4,5-trihydroxyphenylalanine (TOPA) and L-6-bromotryptophan (6-BrW) has been isolated from the morula cells of the vanadium-accumulating ascidian, Phallusia mammillata [1].
The catechols are Dopa methyl ester (dihydroxyphenylalanine methyl ester) and 6-hydroxy-Dopa (trihydroxyphenylalanine). o-Semiquinone radicals are formed in the anaerobic reaction of Dopa methyl ester with hydrogen peroxide catalyzed by native lactoperoxidase [2].

References

Morulin Pm: a modified polypeptide containing TOPA and 6-bromotryptophan from the morula cells of the ascidian, Phallusia mammillata. Taylor, S.W., Kammerer, B., Nicholson, G.J., Pusecker, K., Walk, T., Bayer, E., Scippa, S., de Vincentiis, M. Arch. Biochem. Biophys. (1997) [Pubmed]
Oxidation of the substituted catechols dihydroxyphenylalanine methyl ester and trihydroxyphenylalanine by lactoperoxidase and its compounds. Metodiewa, D., Reszka, K., Dunford, H.B. Arch. Biochem. Biophys. (1989) [Pubmed]

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