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Chemical Compound Review:

Methalone (2R,5S,8R,9S,10S,13S,14S,17S)- 17-hydroxy-2...

Synonyms: Metholone, Medrosteron, Drostanolona, Medrotestron, Drostanolonum, ...

de Boer, D. et al., Teller, M.N. et al., Ballard, C.L. et al.

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Disease relevance of Methalone

Established, 7,12-dimethylbenz(a)anthracene-induced rat mammary carcinomas were treated with 5-fluorouracil (5-FUra) and 2 alpha-methyldihydrotestosterone propionate (MDTP) for 4 weeks [1].

High impact information on Methalone

Here, the authors compared icv self-administration of 4 anabolic steroids (drostanolone, nandrolone, oxymetholone, and stanozolol) at 0.1, 1.0, and 2.0 microg/microl, each for 8 days [2].
Before including the detection of the methyl-5 alpha-dihydrotestosterones mesterolone (1 alpha-methyl-17 beta-hydroxy-5 alpha-androstan-3-one) and drostanolone (2 alpha-methyl-17 beta-hydroxy-5 alpha-androstan-3-one) in doping control procedures, their urinary metabolites were characterized by gas chromatography/mass spectrometry [3].

References

Therapy of 7,12-dimethylbenz(a)anthracene-induced rat mammary carcinomas with combinations of 5-fluorouracil and 2 alpha-methyldihydrotestosterone propionate. Teller, M.N., Stock, C.C., Bowie, M., Chou, T.C., Budinger, J.M. Cancer Res. (1982) [Pubmed]
Intracerebroventricular self-administration of commonly abused anabolic-androgenic steroids in male hamsters (Mesocricetus auratus): nandrolone, drostanolone, oxymetholone, and stanozolol. Ballard, C.L., Wood, R.I. Behav. Neurosci. (2005) [Pubmed]
The methyl-5 alpha-dihydrotestosterones mesterolone and drostanolone; gas chromatographic/mass spectrometric characterization of the urinary metabolites. de Boer, D., de Jong, E.G., Maes, R.A., van Rossum, J.M. J. Steroid Biochem. Mol. Biol. (1992) [Pubmed]

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