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Chemical Compound Review

Proviron     (1S,5S,8R,9S,10R,13S,14S,17S)- 17-hydroxy-1...

Synonyms: Testiwop, Androviron, Mesteranum, Mesterolon, Mestoranum, ...
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Disease relevance of Proviron


Psychiatry related information on Proviron

  • Mesterolone has probably modulated the autonomic innervation of the vesical musculature with correction of the defective neural mechanism which is believed to be implicated in the pathogenesis of nocturnal enuresis [5].

High impact information on Proviron

  • 1 alpha-Methyl-5 alpha-dihydrotestosterone (1 alpha-methyl-DHT; mesterolone) bound most avidly to sex hormone-binding globulin (SHBG) [relative binding affinity (RBA) about 4 times that of DHT] [6].
  • Hormonal therapy is performed with antioestrogens (clomiphene, tamoxifen), gonadotrophin-releasing hormone (GnRH), prolactin inhibitors (bromocriptine), gonadotrophins (hMG, hCG), androgens (testosterone, mesterolone), and testosterone aromatase inhibitors (testolactone) [7].
  • These data suggest that mesterolone itself was not hydroxylated at C18, but rather 1 alpha-methyl-5 alpha-androstan-3,17-dione, an intermediate metabolite which results from oxidation of mesterolone 17-hydroxyl group [8].
  • The overall pregnancy rate was similar in the Mesterolone-treated cases (26%) and in the placebo control cases (48%), although a significant increase in motility and in the proportion of spermatozoa with normal morphology was recorded in the Mesterolone-treated cases [2].
  • The possible effect of Mesterolone (Schering N.V., Brussels, Belgium) (1 alpha-methyl-5-alpha-androstane-17 beta-ol-3-one) on semen quality and fertility of men with idiopathic oligoasthenospermia and/or teratozoospermia has been evaluated in a double-blind trial [2].

Chemical compound and disease context of Proviron


Biological context of Proviron


Anatomical context of Proviron


Associations of Proviron with other chemical compounds


Analytical, diagnostic and therapeutic context of Proviron

  • Seventy-five moderately oligospermic patients showed significant improvement in the sperm density, total sperm count and motility following mesterolone therapy whereas only 12% showed improvement in the severe oligospermic group [23].
  • Based on computer EEG (CEEG) profiles, in high doses, antidepressant properties of mesterolone, a synthetic androgen, were predicted [24].
  • Varicocele ligation and the use of agents such as clomiphene citrate, mesterolone empirical antibiotic therapy, and anabolic steroids have not been show to be beneficial when subject to controlled trials [25].


  1. The hormone response to a synthetic androgen (mesterolone) in oligospermia. Jackaman, F.R., Ansell, I.D., Ghanadian, R., McLoughlin, P.V., Lewis, J.G., Chisholm, G.D. Clin. Endocrinol. (Oxf) (1977) [Pubmed]
  2. Placebo-controlled trial of high-dose Mesterolone treatment of idiopathic male infertility. Gerris, J., Comhaire, F., Hellemans, P., Peeters, K., Schoonjans, F. Fertil. Steril. (1991) [Pubmed]
  3. Mesterolone: thrombosis during treatment, and a study of its prothrombotic effects. Lowe, G.D., Thomson, J.E., Reavey, M.M., Forbes, C.D., Prentice, C.R. British journal of clinical pharmacology. (1979) [Pubmed]
  4. Testosterone levels and gonadotrophins in Klinefelter's patients treated with injections of mesterolone cipionate. Kövary, P.M., Lenau, H., Niermann, H., Zierden, E., Wagner, H. Archives for dermatological research. Archiv für dermatologische Forschung. (1977) [Pubmed]
  5. Treatment of primary nocturnal enuresis by oral androgen mesterolone. A clinical and cystometric study. el-Sadr, A., Sabry, A.A., Abdel-Rahman, M., el-Barnachawy, R., Koraitim, M. Urology (1990) [Pubmed]
  6. Relative binding affinity of anabolic-androgenic steroids: comparison of the binding to the androgen receptors in skeletal muscle and in prostate, as well as to sex hormone-binding globulin. Saartok, T., Dahlberg, E., Gustafsson, J.A. Endocrinology (1984) [Pubmed]
  7. Treatment of male fertility disturbances. Current concepts. Schill, W.B., Michalopoulos, M. Drugs (1984) [Pubmed]
  8. Studies on anabolic steroids--11. 18-hydroxylated metabolites of mesterolone, methenolone and stenbolone: new steroids isolated from human urine. Masse, R., Goudreault, D. J. Steroid Biochem. Mol. Biol. (1992) [Pubmed]
  9. Comparison of the effectiveness of placebo, clomiphene citrate, mesterolone, pentoxifylline, and testosterone rebound therapy for the treatment of idiopathic oligospermia. Wang, C., Chan, C.W., Wong, K.K., Yeung, K.K. Fertil. Steril. (1983) [Pubmed]
  10. Combined mesterolon-clomiphene citrate therapy for treatment of oligospermia. Bandhauer, K., Meili, H.U. Eur. Urol. (1977) [Pubmed]
  11. Randomised trial of mesterolone versus vitamin C for male infertility. Scottish Infertility Group. Hargreave, T.B., Kyle, K.F., Baxby, K., Rogers, A.C., Scott, R., Tolley, D.A., Abel, B.J., Orr, P.S., Elton, R.A. British journal of urology. (1984) [Pubmed]
  12. Psychopharmacological profile of mesterolone. Baran, L., Przegaliński, E. Polish journal of pharmacology and pharmacy. (1981) [Pubmed]
  13. Double-blind group comparative study of testosterone undecanoate and mesterolone in hypogonadal male patients. Luisi, M., Franchi, F. J. Endocrinol. Invest. (1980) [Pubmed]
  14. Double-blind cross over treatment with mesterolone and placebo of subfertile oligozoospermic men value of testicular biopsy. Aafjes, J.H., van der Vijver, J.C., Brugman, F.W., Schenck, P.E. Andrologia (1983) [Pubmed]
  15. The effects of mesterolone on sperm count in idiopathic oligospermia. Bhathena, R.K., Jassawalla, M.J., Patel, D.N. Int. J. Fertil. (1987) [Pubmed]
  16. Plasma cholesterol, triglycerides, FSH and testosterone levels of normolipemic male patients with decreased fertility treated with mesterolone. Nikkanen, V. Andrologia (1979) [Pubmed]
  17. The role of antiandrogenic action in cyproterone acetate-induced morphologic and biochemical changes in human semen. Roy, S., Chatterjee, S. Fertil. Steril. (1979) [Pubmed]
  18. Inhibin production by bovine ovarian tissues in vitro and its regulation by androgens. Henderson, K.M., Franchimont, P. J. Reprod. Fertil. (1983) [Pubmed]
  19. Effect of non aromatizable androgens on LHRH and TRH responses in primary testicular failure. Spitz, I.M., Margalioth, E.J., Yeger, Y., Livshin, Y., Zylber-Haran, E., Shilo, S. Horm. Metab. Res. (1984) [Pubmed]
  20. The effects of mesterolone on the male accessory sex organs, on spermiogram, plasma testosterone and FSH. Nikkanen, V. Andrologia (1978) [Pubmed]
  21. Electrophysiological and psychological changes induced by steroid hormones in men and women. Becker, D., Creutzfeldt, O.D., Schwibbe, M., Wuttke, W. Acta psychiatrica Belgica. (1980) [Pubmed]
  22. Sterility of three brothers in connection with a disturbed carbohydrate metabolism in semen. Horst, C.J., Bol, J.J. Andrologia (1975) [Pubmed]
  23. The effect of mesterolone on sperm count, on serum follicle stimulating hormone, luteinizing hormone, plasma testosterone and outcome in idiopathic oligospermic men. Varma, T.R., Patel, R.H. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics. (1988) [Pubmed]
  24. The effects of mesterolone, a male sex hormone in depressed patients (a double blind controlled study). Itil, T.M., Michael, S.T., Shapiro, D.M., Itil, K.Z. Methods and findings in experimental and clinical pharmacology. (1984) [Pubmed]
  25. The management of male subfertility by in vitro fertilisation techniques. Kovacs, G., McLachlan, R., deKretser, D. Australian family physician. (1995) [Pubmed]
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