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Chemical Compound Review:

Manofast amino-imino-methanesulfinic acid

Synonyms: AIMSA, PubChem18093, F16001_ALDRICH, NSC-34540, NSC-226979, ...

Robertson, J.G. et al., Makarov, S.V. et al., Ballinger, J.R. et al., Gao, Q. et al.

Gao, Liu, Li, Wang,

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Disease relevance of Aminoiminomethanesulphinic acid

Thiourea dioxide was used in chemical modification studies to identify functionally important amino acids in Escherichia coli CTP synthetase [1].

High impact information on Aminoiminomethanesulphinic acid

Inactivation and covalent modification of CTP synthetase by thiourea dioxide [1].
In this report the decomposition and oxidation kinetics of thiourea dioxide and thiourea trioxide are investigated with a reversed-phase ion-pair high-performance liquid chromatography (HPLC) method [2].
Comparisons are made between the decomposition mechanisms of thiourea dioxide (aminoiminomethanesulfinic acid) and HMS [3].
Technetium-99m diethyldithiocarbamate (99mTc-DDC) was prepared by reduction of [99mTc]pertechnetate with formamidine sulfinic acid in the presence of DDC at alkaline pH, both from extemporaneous solutions and in a kit formulation [4].

Associations of Aminoiminomethanesulphinic acid with other chemical compounds

The specificity of thiourea dioxide for lysine residues indicates that one or more lysines are most likely involved in CTP synthetase activity [1].

Analytical, diagnostic and therapeutic context of Aminoiminomethanesulphinic acid

Fluorescence and circular dichroism measurements indicated that modification by thiourea dioxide causes detectable changes in the structure of the protein [1].

References

Inactivation and covalent modification of CTP synthetase by thiourea dioxide. Robertson, J.G., Sparvero, L.J., Villafranca, J.J. Protein Sci. (1992) [Pubmed]
Oxidation and decomposition kinetics of thiourea oxides. Gao, Q., Liu, B., Li, L., Wang, J. The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment & general theory (2007) [Pubmed]
Reactive oxygen species in the aerobic decomposition of sodium hydroxymethanesulfinate. Makarov, S.V., Mundoma, C., Svarovsky, S.A., Shi, X., Gannett, P.M., Simoyi, R.H. Arch. Biochem. Biophys. (1999) [Pubmed]
Technetium-99m diethyldithiocarbamate (DDC): comparison with thallium-201 DDC as an agent for brain imaging. Ballinger, J.R., Gerson, B., Gulenchyn, K.Y. International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes. (1987) [Pubmed]

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