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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 

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Chemical Compound Review: 

Glu-Met     (4S)-4-amino-4-[[(1S)-1- carboxy-3...

Synonyms: L-Glu-L-Met, CHEBI:73507, AC1O52WY, E-M, L-alpha-glutamyl-L-methionine
 
 
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High impact information on Glu-Met

  • We found that mutation of Arg113, located in the first extracellular loop of P-glycoprotein and near the consensus glycosylation sites, to Ala, Lys, Glu, Met, or Cys blocked formation of the 130-kDa product [1].
  • We constructed mutants with five novel amino acid substitutions (Ala, Gly, Glu, Met, and Asp) at codon 74 [2].
  • The inhibitory mAb presented a higher affinity for this sequence and bound to the adjacent sequence, Tyr Lys Glu Met Glu Leu (aa 827-832) [3].
  • In CSF, increased levels of Gln, Arg, Ser and Tyr and decreased levels of Asp, Glu, Met, gamma-aminobutyric acid and Phe were found in MS patients, whereas the levels of other amino acids remained more or the less same in both groups [4].
  • Alcalase was observed to cleave peptide bonds on the carboxyl side of Glu, Met, Leu, Tyr, Lys, and Gln; however, of the twenty-six different cleavage sites, seventeen contained a Glu in the P1 position and of these, fifteen contained a hydrophobic residue in either the P2' or P3' positions [5].

References

  1. Quality control by proteases in the endoplasmic reticulum. Removal of a protease-sensitive site enhances expression of human P-glycoprotein. Loo, T.W., Clarke, D.M. J. Biol. Chem. (1998) [Pubmed]
  2. Mutagenic study of codons 74 and 215 of the human immunodeficiency virus type 1 reverse transcriptase, which are significant in nucleoside analog resistance. Lacey, S.F., Larder, B.A. J. Virol. (1994) [Pubmed]
  3. Characterisation of the binding sites of monoclonal antibodies reacting with the Plasmodium falciparum rhoptry protein RhopH3. Doury, J.C., Goasdoue, J.L., Tolou, H., Martelloni, M., Bonnefoy, S., Mercereau-Puijalon, O. Mol. Biochem. Parasitol. (1997) [Pubmed]
  4. Quantitation of free amino acids in biological samples by high-performance liquid chromatography. Application of the method in evaluating amino acid levels in cerebrospinal fluid and plasma of patients with multiple sclerosis. Qureshi, G.A., Baig, M.S. J. Chromatogr. (1988) [Pubmed]
  5. Characterization of casein phosphopeptides prepared using alcalase: determination of enzyme specificity. Adamson, N.J., Reynolds, E.C. Enzyme Microb. Technol. (1996) [Pubmed]
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