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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
 
Chemical Compound Review

Trp-Leu     (2S)-2-[[(2R)-2-amino-3-(1H- indol-3...

Synonyms: AC1O530K
 
 
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High impact information on Trp-Leu

  • The overall results indicated that Met imbalance was very severe, followed in decreasing order by Ile, Trp, Leu and Val, His, Phe, Thr, Lys and Arg imbalance [1].
  • The amino acid sequences of these inhibitors determined by Edman degradation were Ile-Phe-Leu (IC(50), 44.8 microM) and Trp-Leu (IC(50), 29.9 microM) [2].
  • N-terminal sequences of the 31 ku and 30 ku antigen were Ala Glu Val Asp Trp Leu Val Phe Ala Val and Phe Ser Arg Pro Gly Leu Pro Val Glu Try respectively [3].
  • Some evidence for a plasma membrane dipeptidase, which hydrolyzes Trp-Leu but not Arg-Phe or Arg-Gly, also was found [4].
 

Analytical, diagnostic and therapeutic context of Trp-Leu

  • In the current study, we examined the free radical intermediates formed during ultrasound exposure of a typical cell culture medium (RPMI-1640); the dominant free radicals that were identified by spin trapping were derived from the hydrophobic amino acids Trp, Leu, and Phe, and were formed by hydrogen abstraction from these amino acids [5].

References

 
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