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Chemical Compound Review:

Mofegiline (2E)-2-(fluoromethylidene)-4- (4...

Synonyms: CHEMBL489079, SureCN1295041, CHEBI:553850, MDL-72,974, AC1O5OIU, ...

Stoltz, M. et al., Huebert, N.D. et al.

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High impact information on Mofegiline

Pharmacokinetics and pharmacodynamics of the monoamine oxidase B inhibitor mofegiline assessed during a phase I dose tolerance trial [1].
The safety, pharmacokinetics, and pharmacodynamics of single oral doses of up to 48 mg and daily (for 28 days) doses of up 24 mg mofegiline were investigated in healthy male volunteers [1].
Kinetics and metabolism of p-tyramine during monoamine oxidase inhibition by mofegiline [2].

References

Pharmacokinetics and pharmacodynamics of the monoamine oxidase B inhibitor mofegiline assessed during a phase I dose tolerance trial. Stoltz, M., Reynolds, D., Elkins, L., Salazar, D., Weir, S. Clin. Pharmacol. Ther. (1995) [Pubmed]
Kinetics and metabolism of p-tyramine during monoamine oxidase inhibition by mofegiline. Huebert, N.D., Dulery, B.D., Schoun, J., Schwach, V., Hinze, C., Haegele, K.D. Clin. Pharmacol. Ther. (1994) [Pubmed]

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