The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
Chemical Compound Review

CHEMBL93628     5-[(E)-2-(3,5,5,8,8- pentamethyl-6,7...

Synonyms: SureCN3685267, CHEBI:250246, LS-153059, Agn 191701, AC1O5P5S, ...
Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Agn 191701

  • (E)-2-[2-(5,6,7,8-Tetrahydro-3,5,5,8,8-pentamethyl-2-naphthyl) propen-1-yl]-4-thiophenecarboxylic acid (AGN 191701) and other retinoid X receptor (RXR)-selective agonists were observed to cause hepatomegaly in rats [1].
  • To determine if AGN 191701-induced hepatic hyperplasia was sustained, rats were treated by gavage with 60 mumol/kg of AGN 191701 for up to 7 days and exposed to BrdU via osmotic pump on days 1-3 or on days 6-8 [1].
  • Two RXR-selective agonists, LG100268 and AGN 191701, failed to induce hypertriglyceridemia or weight loss up to the highest doses tested [2].

High impact information on Agn 191701

  • Hepatocyte L1 and mitotic index were increased only in rats exposed to BrdU on days 1-3, indicating that AGN 191701-induced hepatocyte proliferation was transient [1].
  • AGN 191701 caused dose-dependent hepatomegaly in the absence of hepatic necrosis and necrosis and increased hepatocyte BrdU labeling index (LI) [1].
  • To determine if RXR agonists have biochemical effects in common with a peroxisome proliferator, various endpoints were measured 24 hr after two daily treatments with AGN 191701, SR11237, or clofibrate [1].
  • The ED50 value of the RXR-selective AGN 191701 was 600 nmol/animal compared with an ED50 value of 0.2 nmol for the structurally similar RAR-selective TTNPB [3].


  1. Mitogenic effect of retinoid X receptor agonists in rat liver. Standeven, A.M., Escobar, M., Beard, R.L., Yuan, Y.D., Chandraratna, R.A. Biochem. Pharmacol. (1997) [Pubmed]
  2. Retinoid-induced hypertriglyceridemia in rats is mediated by retinoic acid receptors. Standeven, A.M., Beard, R.L., Johnson, A.T., Boehm, M.F., Escobar, M., Heyman, R.A., Chandraratna, R.A. Fundamental and applied toxicology : official journal of the Society of Toxicology. (1996) [Pubmed]
  3. Receptor specificity of retinoid-induced epidermal hyperplasia: effect of RXR-selective agonists and correlation with topical irritation. Thacher, S.M., Standeven, A.M., Athanikar, J., Kopper, S., Castilleja, O., Escobar, M., Beard, R.L., Chandraratna, R.A. J. Pharmacol. Exp. Ther. (1997) [Pubmed]
WikiGenes - Universities