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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Mitotic Index

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Disease relevance of Mitotic Index


High impact information on Mitotic Index


Chemical compound and disease context of Mitotic Index


Biological context of Mitotic Index

  • Replication of the genome did not appear to be affected by the drug because the scheduled synthesis of DNA and activation of cdc2 kinase followed by increase in mitotic index occurred normally, while VP-16, a cleavable, complex-stabilizing type topo II inhibitor, inhibited all these processes [16].
  • Because the left ventricle contains 5.8 x 10(9) myocytes, these mitotic indices imply that 81.2 x 10(3), 882 x 10(3), and 760 x 10(3) myocytes were in mitosis in the entire ventricular myocardium of control hearts and hearts affected by ischemic and idiopathic dilated cardiomyopathy, respectively [17].
  • The proliferative potential of cultured epididymal cells obtained from pubertal and old adult donors can be documented by [3H]thymidine labeling and mitotic indices without significant loss of gene expression for acidic epididymal glycoprotein [18].
  • The formation of the lens pre-placode appears to be unaffected in heterozygotes, as deduced from the number of cells, the mitotic index, the amount of apoptosis and the expression of SOX2 and Pax6 in the pre-placode [19].
  • The effects of TP at doses of 0, 100, 200, and 400 micrograms/day on cell division and cell death in SCC8 tumors of medium size were examined by measurements of the mitotic index and the retention of 5-[125I]iodo-2'-deoxyuridine incorporated into the whole tumor [20].

Anatomical context of Mitotic Index


Associations of Mitotic Index with chemical compounds

  • The mitotic index for each acinar zone was calculated at the time of peak thymidine incorporation after each drug and then at 12-hr intervals for the next 24 hr [26].
  • Using successive [3H]thymidine pulses and autoradiography, increases in labeling (p less than 0.01) and mitotic indices (p less than 0.05) were observed in the caerulein group, whereas pentagastrin had no effect [27].
  • The responses in thymidine kinase activity and mitotic indices showed tha peak regeneration occurred at 3-4 days [28].
  • Scarring is markedly reduced in MRL mice compared with C57BL/6 mice, consistent with both the reduced hydroxyproline levels seen after injury and an elevated cardiomyocyte mitotic index of 10-20% for the MRL compared with 1-3% for the C57BL/6 [29].
  • Among -/- and +/+ mice that survived, -/- mice tend to suffer greater oxidative damage and failed to repair or regenerate damaged renal tissues, as indicated by their higher plasma malonaldehyde (MDA) and 4-hydroxy-2(E)-nonenal (HNE) levels and lower mitotic indices in their kidneys, respectively [30].

Gene context of Mitotic Index

  • Overexpression of GCR1 in tobacco (Nicotiana tabacum) BY-2 cells caused an increase in thymidine incorporation and in the mitotic index of aphidicolin synchronized cells [31].
  • Cdc2 overexpression and the elevated mitotic indices in the HCCs correlated also with induction of cyclin B steady-state levels [32].
  • These growth rates correlate with position-dependent differences in blastemal length, mitotic index and expression of the Fgf target genes mkp3, sef and spry4 [33].
  • When KLF4 was inhibited by small interfering RNA, irradiated HCT116 cells exhibited increased mitotic indices and a rise in cyclin B1 levels [34].
  • However, once the tumors appeared, their growth rate, apoptosis level, and mitotic index were not affected by the loss of p21, suggesting that loss of p21 is critical in early but not late events of Ras oncogenesis [35].

Analytical, diagnostic and therapeutic context of Mitotic Index


  1. Inhibition of mouse skin tumor promotion and of promoter-stimulated epidermal polyamine biosynthesis by alpha-difluoromethylornithine. Takigawa, M., Verma, A.K., Simsiman, R.C., Boutwell, R.K. Cancer Res. (1983) [Pubmed]
  2. Expression of Id helix-loop-helix proteins in colorectal adenocarcinoma correlates with p53 expression and mitotic index. Wilson, J.W., Deed, R.W., Inoue, T., Balzi, M., Becciolini, A., Faraoni, P., Potten, C.S., Norton, J.D. Cancer Res. (2001) [Pubmed]
  3. Shape-dependent regulation of proliferation in normal and malignant human cells and its alteration by interferon. Kulesh, D.A., Greene, J.J. Cancer Res. (1986) [Pubmed]
  4. Cell deletion by apoptosis during regression of renal hyperplasia. Ledda-Columbano, G.M., Columbano, A., Coni, P., Faa, G., Pani, P. Am. J. Pathol. (1989) [Pubmed]
  5. Changes in cytoskeletal protein composition indicative of an epithelial-mesenchymal transition in human micrometastatic and primary breast carcinoma cells. Willipinski-Stapelfeldt, B., Riethdorf, S., Assmann, V., Woelfle, U., Rau, T., Sauter, G., Heukeshoven, J., Pantel, K. Clin. Cancer Res. (2005) [Pubmed]
  6. A human BRCA2 complex containing a structural DNA binding component influences cell cycle progression. Marmorstein, L.Y., Kinev, A.V., Chan, G.K., Bochar, D.A., Beniya, H., Epstein, J.A., Yen, T.J., Shiekhattar, R. Cell (2001) [Pubmed]
  7. Noradrenaline and cyclic AMP--independent growth stimulation in newt limb blastemata. Rathbone, M.P., Petri, J., Choo, A.F., Logan, D.M., Carlone, R.L., Foret, J.E. Nature (1980) [Pubmed]
  8. Requirement of a corepressor for Dr1-mediated repression of transcription. Mermelstein, F., Yeung, K., Cao, J., Inostroza, J.A., Erdjument-Bromage, H., Eagelson, K., Landsman, D., Levitt, P., Tempst, P., Reinberg, D. Genes Dev. (1996) [Pubmed]
  9. Growth inhibition of estrogen-dependent and estrogen-independent MXT mammary cancers in mice by the bombesin and gastrin-releasing peptide antagonist RC-3095. Szepeshazi, K., Schally, A.V., Halmos, G., Groot, K., Radulovic, S. J. Natl. Cancer Inst. (1992) [Pubmed]
  10. Growth and regrowth of an autogenous rat sarcoma: effects of nitrogen mustard. Post, J., Sklarew, R.J., Hoffman, J. J. Natl. Cancer Inst. (1975) [Pubmed]
  11. Comparative analysis of proliferating cell nuclear antigen, bromodeoxyuridine, and mitotic index in uveal melanoma. Ghazvini, S., Kroll, S., Char, D.H., Frigillana, H. Invest. Ophthalmol. Vis. Sci. (1995) [Pubmed]
  12. Selective action of hydrocortisone on postmitotic epidermal cells in vivo. Laurence, E.B., Christophers, E. J. Invest. Dermatol. (1976) [Pubmed]
  13. DNA flow cytometry, nuclear morphometry, mitotic indices and steroid receptors as independent prognostic factors in female breast cancer. Eskelinen, M., Lipponen, P., Papinaho, S., Aaltomaa, S., Kosma, V.M., Klemi, P., Syrjänen, K. Int. J. Cancer (1992) [Pubmed]
  14. AT1 receptor is present in glioma cells; its blockage reduces the growth of rat glioma. Rivera, E., Arrieta, O., Guevara, P., Duarte-Rojo, A., Sotelo, J. Br. J. Cancer (2001) [Pubmed]
  15. Conjugated linoleic acid content in breast adipose tissue of breast cancer patients and the risk of metastasis. Chajes, V., Lavillonniere, F., Maillard, V., Giraudeau, B., Jourdan, M.L., Sebedio, J.L., Bougnoux, P. Nutrition and cancer. (2003) [Pubmed]
  16. Inhibition of DNA topoisomerase II by ICRF-193 induces polyploidization by uncoupling chromosome dynamics from other cell cycle events. Ishida, R., Sato, M., Narita, T., Utsumi, K.R., Nishimoto, T., Morita, T., Nagata, H., Andoh, T. J. Cell Biol. (1994) [Pubmed]
  17. Myocyte proliferation in end-stage cardiac failure in humans. Kajstura, J., Leri, A., Finato, N., Di Loreto, C., Beltrami, C.A., Anversa, P. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  18. Isolation, culture, and immunocytochemical characterization of epididymal epithelial cells from pubertal and adult rats. Kierszenbaum, A.L., Lea, O., Petrusz, P., French, F.S., Tres, L.L. Proc. Natl. Acad. Sci. U.S.A. (1981) [Pubmed]
  19. Dosage requirement and allelic expression of PAX6 during lens placode formation. van Raamsdonk, C.D., Tilghman, S.M. Development (2000) [Pubmed]
  20. Androgen dependency of a tumor produced by a cell line derived from androgen-responsive Shionogi carcinoma 115. Terada, N., Yamamoto, R., Uchida, N., Takada, T., Taniguchi, H., Takatsuka, D., Sawada, M., Tsuji, M., Li, W., Kitamura, Y. Cancer Res. (1989) [Pubmed]
  21. Growth hormone-releasing factor (somatocrinin) stimulates epithelial cell proliferation in the rat digestive tract. Lehy, T., Accary, J.P., Dubrasquet, M., Lewin, M.J. Gastroenterology (1986) [Pubmed]
  22. Pyrrolidinedithiocarbamate increases the therapeutic index of 5-fluorouracil in a mouse model. Bach, S.P., Chinery, R., O'Dwyer, S.T., Potten, C.S., Coffey, R.J., Watson, A.J. Gastroenterology (2000) [Pubmed]
  23. Estradiol-activated alpha-fetoprotein suppresses the uterotropic response to estrogens. Mizejewski, G.J., Vonnegut, M., Jacobson, H.I. Proc. Natl. Acad. Sci. U.S.A. (1983) [Pubmed]
  24. Liver DNA synthesis promoter activity detected in human plasma from subjects with hepatitis. Díaz-Gil, J.J., Sánchez, G., Santamaría, L., Trilla, C., Esteban, P., Escartín, P. Hepatology (1986) [Pubmed]
  25. Effect of stathmin on the sensitivity to antimicrotubule drugs in human breast cancer. Alli, E., Bash-Babula, J., Yang, J.M., Hait, W.N. Cancer Res. (2002) [Pubmed]
  26. Acinar distribution of liver cell regeneration after selective zonal injury in the rat. Nostrant, T.T., Miller, D.L., Appelman, H.D., Gumucio, J.J. Gastroenterology (1978) [Pubmed]
  27. Effect of cholecystokinin-octapeptide, caerulein, and pentagastrin on epithelial cell proliferation in the murine gallbladder. Lamote, J., Putz, P., Willems, G. Gastroenterology (1982) [Pubmed]
  28. Thymidine kinase: an inexpensive index of liver regeneration in a large animal model. Kahn, D., Stadler, J., Terblanche, J., van Hoorn-Hickman, R. Gastroenterology (1980) [Pubmed]
  29. Heart regeneration in adult MRL mice. Leferovich, J.M., Bedelbaeva, K., Samulewicz, S., Zhang, X.M., Zwas, D., Lankford, E.B., Heber-Katz, E. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  30. Increased susceptibility in Hp knockout mice during acute hemolysis. Lim, S.K., Kim, H., Lim, S.K., bin Ali, A., Lim, Y.K., Wang, Y., Chong, S.M., Costantini, F., Baumman, H. Blood (1998) [Pubmed]
  31. GCR1, the putative Arabidopsis G protein-coupled receptor gene is cell cycle-regulated, and its overexpression abolishes seed dormancy and shortens time to flowering. Colucci, G., Apone, F., Alyeshmerni, N., Chalmers, D., Chrispeels, M.J. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  32. Disruption of the pRb/E2F pathway and inhibition of apoptosis are major oncogenic events in liver constitutively expressing c-myc and transforming growth factor alpha. Santoni-Rugiu, E., Jensen, M.R., Thorgeirsson, S.S. Cancer Res. (1998) [Pubmed]
  33. Fgf signaling instructs position-dependent growth rate during zebrafish fin regeneration. Lee, Y., Grill, S., Sanchez, A., Murphy-Ryan, M., Poss, K.D. Development (2005) [Pubmed]
  34. Requirement of Krüppel-like factor 4 in preventing entry into mitosis following DNA damage. Yoon, H.S., Yang, V.W. J. Biol. Chem. (2004) [Pubmed]
  35. Loss of p21WAF1/CIP1 accelerates Ras oncogenesis in a transgenic/knockout mammary cancer model. Adnane, J., Jackson, R.J., Nicosia, S.V., Cantor, A.B., Pledger, W.J., Sebti, S.M. Oncogene (2000) [Pubmed]
  36. Sex hormone-related functions in regenerating male rat liver. Francavilla, A., Eagon, P.K., DiLeo, A., Polimeno, L., Panella, C., Aquilino, A.M., Ingrosso, M., Van Thiel, D.H., Starzl, T.E. Gastroenterology (1986) [Pubmed]
  37. Colonic epithelial cell proliferation in hereditary non-polyposis colorectal cancer. Green, S.E., Chapman, P., Burn, J., Burt, A.D., Bennett, M., Appleton, D.R., Varma, J.S., Mathers, J.C. Gut (1998) [Pubmed]
  38. Cell cycle analysis and chromosomal localization of human Plk1, a putative homologue of the mitotic kinases Drosophila polo and Saccharomyces cerevisiae Cdc5. Golsteyn, R.M., Schultz, S.J., Bartek, J., Ziemiecki, A., Ried, T., Nigg, E.A. J. Cell. Sci. (1994) [Pubmed]
  39. Angiogenesis as a prognostic marker in breast carcinoma with conventional adjuvant chemotherapy: a multiparametric and immunohistochemical analysis. Jacquemier, J.D., Penault-Llorca, F.M., Bertucci, F., Sun, Z.Z., Houvenaeghel, G.F., Geneix, J.A., Puig, B.D., Bardou, V.J., Hassoun, J.A., Birnbaum, D., Viens, P.J. J. Pathol. (1998) [Pubmed]
  40. Pleomorphic adenoma cells vary in their susceptibility to SV40 transformation depending on the initial karyotype. Kazmierczak, B., Thode, B., Bartnitzke, S., Bullerdiek, J., Schloot, W. Genes Chromosomes Cancer (1992) [Pubmed]
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