Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

DOPSE (2S)-2-amino-3-[[(2R)-2,3- bis[[(Z)-octadec...

Synonyms: CHEBI:60568, HMDB12390, LMGP03010030, AC1O5Q1P, PS(36:2), ...

Andree, H.A. et al., Brügger, B. et al., Kinkaid, A.R. et al.

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High impact information on Dioleoyl phosphatidylserine

It has recently been reported that N-ethylmaleimide-sensitive fusion ATPase (NSF) can fuse protein-free liposomes containing substantial amounts of 1,2-dioleoylphosphatidylserine (DOPS) and 1, 2-dioleoyl-phosphatidyl-ethanolamine (DOPE) (Otter-Nilsson et al., 1999) [1].
These surfaces all showed the same maximal adsorption of 0.22 +/- 0.01 micrograms of VAC alpha/cm2 (mean +/- S.D.). The adsorption to bilayers containing more than 10% DOPS was independent of VAC alpha concentrations in the range of 0.5-100 nM [2].
Activation of DOPC hydrolysis was also achieved with dioleoyl-phosphatidylserine (DOPS); however, DOPS was less effective than cholesterol sulphate [3].

Associations of Dioleoyl phosphatidylserine with other chemical compounds

The ability to mediate VAC alpha binding to 20% DOPS/80% DOPC bilayers was highly specific for Ca2+ [2].

References

Putative fusogenic activity of NSF is restricted to a lipid mixture whose coalescence is also triggered by other factors. Brügger, B., Nickel, W., Weber, T., Parlati, F., McNew, J.A., Rothman, J.E., Söllner, T. EMBO J. (2000) [Pubmed]
Binding of vascular anticoagulant alpha (VAC alpha) to planar phospholipid bilayers. Andree, H.A., Reutelingsperger, C.P., Hauptmann, R., Hemker, H.C., Hermens, W.T., Willems, G.M. J. Biol. Chem. (1990) [Pubmed]
Enhanced hydrolysis of phosphatidylcholine by human group II non-pancreatic secreted phospholipase A2 as a result of interfacial activation by specific anions. Potential role of cholesterol sulphate. Kinkaid, A.R., Wilton, D.C. Biochem. J. (1995) [Pubmed]

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