Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

CHEBI:39157 (2E,4E)-7-(4- dimethylaminophenyl)-4,6...

Synonyms: AC1O5RA8, 114127-17-2, Trichostatic acid

Sanderson, L. et al.

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High impact information on Trichostatic acid

Trichostatin A underwent extensive metabolism: primary metabolic pathways were N-demethylation, reduction of the hydroxamic acid to the corresponding trichostatin A amide, and oxidative deamination to trichostatic acid [1].
Trichostatic acid underwent further biotransformation: reduction and beta-oxidation of the carboxylic acid, with or without N-demethylation, resulted in formation of dihydro trichostatic acid and dinor dihydro trichostatic acids [1].

References

Plasma pharmacokinetics and metabolism of the histone deacetylase inhibitor trichostatin a after intraperitoneal administration to mice. Sanderson, L., Taylor, G.W., Aboagye, E.O., Alao, J.P., Latigo, J.R., Coombes, R.C., Vigushin, D.M. Drug Metab. Dispos. (2004) [Pubmed]

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