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Chemical Compound Review

trichostatin A     (2E,4E,6R)-7-(4- dimethylaminophenyl)-N...

Synonyms: Tricostatin A, CHEMBL99, SGCTO-002, GNF-PF-1011, S1045_Selleck, ...
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Disease relevance of Trichlostatin A


Psychiatry related information on Trichlostatin A


High impact information on Trichlostatin A

  • Finally, the histone deacetylase inhibitor trichostatin A (ref. 17) relieves transcriptional repression mediated by EED, but not by HPC2, a human homologue of polycomb [7].
  • Exogenous MBD2 represses transcription in a transient assay, and repression can be relieved by the deacetylase inhibitor trichostatin A (TSA; ref. 12) [8].
  • Significantly, inhibition of p53-mediated transcriptional repression with TSA markedly inhibits apoptosis induction by p53 [9].
  • We report that trichostatin A (TSA), an inhibitor of histone deacetylases (HDACs), abrogates the ability of p53 to repress the transcription of two genes that it negatively regulates, Map4 and stathmin [9].
  • TSA treatment, however, did not detectably alter enhancer factor binding or the positioning of nuc-1 on the majority of the chromatin templates indicating that protein acetylation and chromatin remodeling may be limiting steps that occur only on transcriptionally competent templates, or that remodeling of nuc-1 requires additional factors [2].

Chemical compound and disease context of Trichlostatin A


Biological context of Trichlostatin A


Anatomical context of Trichlostatin A


Associations of Trichlostatin A with other chemical compounds


Gene context of Trichlostatin A


Analytical, diagnostic and therapeutic context of Trichlostatin A


  1. Histone deacetylases induce angiogenesis by negative regulation of tumor suppressor genes. Kim, M.S., Kwon, H.J., Lee, Y.M., Baek, J.H., Jang, J.E., Lee, S.W., Moon, E.J., Kim, H.S., Lee, S.K., Chung, H.Y., Kim, C.W., Kim, K.W. Nat. Med. (2001) [Pubmed]
  2. Histone acetyltransferases regulate HIV-1 enhancer activity in vitro. Sheridan, P.L., Mayall, T.P., Verdin, E., Jones, K.A. Genes Dev. (1997) [Pubmed]
  3. Cardiac hypertrophy and histone deacetylase-dependent transcriptional repression mediated by the atypical homeodomain protein Hop. Kook, H., Lepore, J.J., Gitler, A.D., Lu, M.M., Wing-Man Yung, W., Mackay, J., Zhou, R., Ferrari, V., Gruber, P., Epstein, J.A. J. Clin. Invest. (2003) [Pubmed]
  4. Histone deacetylase inhibitors modulate renal disease in the MRL-lpr/lpr mouse. Mishra, N., Reilly, C.M., Brown, D.R., Ruiz, P., Gilkeson, G.S. J. Clin. Invest. (2003) [Pubmed]
  5. NF-kappaB p50 promotes HIV latency through HDAC recruitment and repression of transcriptional initiation. Williams, S.A., Chen, L.F., Kwon, H., Ruiz-Jarabo, C.M., Verdin, E., Greene, W.C. EMBO J. (2006) [Pubmed]
  6. Cell cycle blockade and differentiation of ovarian cancer cells by the histone deacetylase inhibitor trichostatin A are associated with changes in p21, Rb, and Id proteins. Strait, K.A., Dabbas, B., Hammond, E.H., Warnick, C.T., Iistrup, S.J., Ford, C.D. Mol. Cancer Ther. (2002) [Pubmed]
  7. Transcriptional repression mediated by the human polycomb-group protein EED involves histone deacetylation. van der Vlag, J., Otte, A.P. Nat. Genet. (1999) [Pubmed]
  8. MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex. Ng, H.H., Zhang, Y., Hendrich, B., Johnson, C.A., Turner, B.M., Erdjument-Bromage, H., Tempst, P., Reinberg, D., Bird, A. Nat. Genet. (1999) [Pubmed]
  9. Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a. Murphy, M., Ahn, J., Walker, K.K., Hoffman, W.H., Evans, R.M., Levine, A.J., George, D.L. Genes Dev. (1999) [Pubmed]
  10. A class of hybrid polar inducers of transformed cell differentiation inhibits histone deacetylases. Richon, V.M., Emiliani, S., Verdin, E., Webb, Y., Breslow, R., Rifkind, R.A., Marks, P.A. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  11. A histone deacetylase inhibitor potentiates retinoid receptor action in embryonal carcinoma cells. Minucci, S., Horn, V., Bhattacharyya, N., Russanova, V., Ogryzko, V.V., Gabriele, L., Howard, B.H., Ozato, K. Proc. Natl. Acad. Sci. U.S.A. (1997) [Pubmed]
  12. Restoration of tamoxifen sensitivity in estrogen receptor-negative breast cancer cells: tamoxifen-bound reactivated ER recruits distinctive corepressor complexes. Sharma, D., Saxena, N.K., Davidson, N.E., Vertino, P.M. Cancer Res. (2006) [Pubmed]
  13. Functional epigenomics identifies genes frequently silenced in prostate cancer. Lodygin, D., Epanchintsev, A., Menssen, A., Diebold, J., Hermeking, H. Cancer Res. (2005) [Pubmed]
  14. Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors. Finnin, M.S., Donigian, J.R., Cohen, A., Richon, V.M., Rifkind, R.A., Marks, P.A., Breslow, R., Pavletich, N.P. Nature (1999) [Pubmed]
  15. Epigenetic silencing of RNA polymerase I transcription: a role for DNA methylation and histone modification in nucleolar dominance. Chen, Z.J., Pikaard, C.S. Genes Dev. (1997) [Pubmed]
  16. Chromatin remodeling by the T cell receptor (TCR)-beta gene enhancer during early T cell development: Implications for the control of TCR-beta locus recombination. Mathieu, N., Hempel, W.M., Spicuglia, S., Verthuy, C., Ferrier, P. J. Exp. Med. (2000) [Pubmed]
  17. Interleukin 7 receptor control of T cell receptor gamma gene rearrangement: role of receptor-associated chains and locus accessibility. Durum, S.K., Candèias, S., Nakajima, H., Leonard, W.J., Baird, A.M., Berg, L.J., Muegge, K. J. Exp. Med. (1998) [Pubmed]
  18. CBP histone acetyltransferase activity is a critical component of memory consolidation. Korzus, E., Rosenfeld, M.G., Mayford, M. Neuron (2004) [Pubmed]
  19. Synergism of Xist RNA, DNA methylation, and histone hypoacetylation in maintaining X chromosome inactivation. Csankovszki, G., Nagy, A., Jaenisch, R. J. Cell Biol. (2001) [Pubmed]
  20. In vivo destabilization of dynamic microtubules by HDAC6-mediated deacetylation. Matsuyama, A., Shimazu, T., Sumida, Y., Saito, A., Yoshimatsu, Y., Seigneurin-Berny, D., Osada, H., Komatsu, Y., Nishino, N., Khochbin, S., Horinouchi, S., Yoshida, M. EMBO J. (2002) [Pubmed]
  21. Distinct requirements for chromatin assembly in transcriptional repression by thyroid hormone receptor and histone deacetylase. Wong, J., Patterton, D., Imhof, A., Guschin, D., Shi, Y.B., Wolffe, A.P. EMBO J. (1998) [Pubmed]
  22. Switch from Myc/Max to Mad1/Max binding and decrease in histone acetylation at the telomerase reverse transcriptase promoter during differentiation of HL60 cells. Xu, D., Popov, N., Hou, M., Wang, Q., Björkholm, M., Gruber, A., Menkel, A.R., Henriksson, M. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  23. Theophylline restores histone deacetylase activity and steroid responses in COPD macrophages. Cosio, B.G., Tsaprouni, L., Ito, K., Jazrawi, E., Adcock, I.M., Barnes, P.J. J. Exp. Med. (2004) [Pubmed]
  24. In vivo haematopoietic activity is induced in neurosphere cells by chromatin-modifying agents. Schmittwolf, C., Kirchhof, N., Jauch, A., Dürr, M., Harder, F., Zenke, M., Müller, A.M. EMBO J. (2005) [Pubmed]
  25. Expression of mutant dynamin inhibits toxicity and transport of endocytosed ricin to the Golgi apparatus. Llorente, A., Rapak, A., Schmid, S.L., van Deurs, B., Sandvig, K. J. Cell Biol. (1998) [Pubmed]
  26. Depudecin induces morphological reversion of transformed fibroblasts via the inhibition of histone deacetylase. Kwon, H.J., Owa, T., Hassig, C.A., Shimada, J., Schreiber, S.L. Proc. Natl. Acad. Sci. U.S.A. (1998) [Pubmed]
  27. Stra13 expression is associated with growth arrest and represses transcription through histone deacetylase (HDAC)-dependent and HDAC-independent mechanisms. Sun, H., Taneja, R. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  28. Essential role of Drosophila Hdac1 in homeotic gene silencing. Chang, Y.L., Peng, Y.H., Pan, I.C., Sun, D.S., King, B., Huang, D.H. Proc. Natl. Acad. Sci. U.S.A. (2001) [Pubmed]
  29. Yeast HOS3 forms a novel trichostatin A-insensitive homodimer with intrinsic histone deacetylase activity. Carmen, A.A., Griffin, P.R., Calaycay, J.R., Rundlett, S.E., Suka, Y., Grunstein, M. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  30. Genomewide studies of histone deacetylase function in yeast. Bernstein, B.E., Tong, J.K., Schreiber, S.L. Proc. Natl. Acad. Sci. U.S.A. (2000) [Pubmed]
  31. A developmental switch in H4 acetylation upstream of Xist plays a role in X chromosome inactivation. O'Neill, L.P., Keohane, A.M., Lavender, J.S., McCabe, V., Heard, E., Avner, P., Brockdorff, N., Turner, B.M. EMBO J. (1999) [Pubmed]
  32. Inhibitors of histone deacetylase and DNA methyltransferase synergistically activate the methylated metallothionein I promoter by activating the transcription factor MTF-1 and forming an open chromatin structure. Ghoshal, K., Datta, J., Majumder, S., Bai, S., Dong, X., Parthun, M., Jacob, S.T. Mol. Cell. Biol. (2002) [Pubmed]
  33. Synergistic effect of histone hyperacetylation and DNA demethylation in the reactivation of the FMR1 gene. Chiurazzi, P., Pomponi, M.G., Pietrobono, R., Bakker, C.E., Neri, G., Oostra, B.A. Hum. Mol. Genet. (1999) [Pubmed]
  34. Histone acetylation dependent allelic expression imbalance of BAPX1 in patients with the oculo-auriculo-vertebral spectrum. Fischer, S., Lüdecke, H.J., Wieczorek, D., Böhringer, S., Gillessen-Kaesbach, G., Horsthemke, B. Hum. Mol. Genet. (2006) [Pubmed]
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