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Chemical Compound Review

trichostatin A     (2E,4E,6R)-7-(4- dimethylaminophenyl)-N...

Synonyms: Tricostatin A, CHEMBL99, SGCTO-002, GNF-PF-1011, S1045_Selleck, ...
 
 
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Disease relevance of Trichlostatin A

 

Psychiatry related information on Trichlostatin A

 

High impact information on Trichlostatin A

  • Finally, the histone deacetylase inhibitor trichostatin A (ref. 17) relieves transcriptional repression mediated by EED, but not by HPC2, a human homologue of polycomb [7].
  • Exogenous MBD2 represses transcription in a transient assay, and repression can be relieved by the deacetylase inhibitor trichostatin A (TSA; ref. 12) [8].
  • Significantly, inhibition of p53-mediated transcriptional repression with TSA markedly inhibits apoptosis induction by p53 [9].
  • We report that trichostatin A (TSA), an inhibitor of histone deacetylases (HDACs), abrogates the ability of p53 to repress the transcription of two genes that it negatively regulates, Map4 and stathmin [9].
  • TSA treatment, however, did not detectably alter enhancer factor binding or the positioning of nuc-1 on the majority of the chromatin templates indicating that protein acetylation and chromatin remodeling may be limiting steps that occur only on transcriptionally competent templates, or that remodeling of nuc-1 requires additional factors [2].
 

Chemical compound and disease context of Trichlostatin A

 

Biological context of Trichlostatin A

 

Anatomical context of Trichlostatin A

 

Associations of Trichlostatin A with other chemical compounds

 

Gene context of Trichlostatin A

 

Analytical, diagnostic and therapeutic context of Trichlostatin A

References

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