Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

LS-57681 9-[3- (diaminomethylideneamino) propyl]-2...

Synonyms: LS-57682, AC1O60II, 146109-35-5, Dihydronodularin, (D-MeAbu5)nodularin

Namikoshi, M. et al., Spoof, L. et al.

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Disease relevance of Dihydronodularin

The two stereoisomers of both dihydronodularin (2 and 3) and dihydromicrocystin-LR (5 and 6), isolated by reversed-phase HPLC, showed similar toxicity to each other [ip in mice, LD50 = 150 (2), 150 (3), 85 (5), and 100 (6) micrograms/kg] [1].

High impact information on Dihydronodularin

The optimised reaction gave two dihydronodularin stereoisomers which were purified by high-performance liquid chromatography with a mobile phase of methanol-0.7% sodium sulfate (6:4) and a C(18) stationary phase [2].

References

Chemical characterization and toxicity of dihydro derivatives of nodularin and microcystin-LR, potent cyanobacterial cyclic peptide hepatotoxins. Namikoshi, M., Choi, B.W., Sun, F., Rinehart, K.L., Evans, W.R., Carmichael, W.W. Chem. Res. Toxicol. (1993) [Pubmed]
Synthesis and organotropism of 3H-dihydro derivatives of the cyanobacterial peptide hepatotoxin nodularin. Spoof, L., Klimova, S., Mikhailov, A., Eriksson, J.E., Meriluoto, J. Toxicon (2003) [Pubmed]

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