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Chemical Compound Review: 

Benzilsaeure     2-hydroxy-2,2-diphenyl- ethanoic acid

Synonyms: BENZILIC ACID, Benzylic acid, SureCN7066, B5194_ALDRICH, AGN-PC-0CKK45, ...
 
 
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High impact information on BENZILIC ACID

  • Oral administration of benzilic acid ester-based acaricide bromopropylate at daily doses of 3, 15, 100, and 300 mg/kg body wt to young adult male Tif:MAGf mice for 14 days caused slightly increased liver weights in the high-dose group [1].
  • Furthermore, contrary to literature speculations, 2-methyl-4, 5-dihydro-3(2H)-furanone was shown to be formed by ring contraction of 2,3-dihydro-3,5-dihydroxy-6-methyl-4(H)-pyran-4-one, through benzilic acid rearrangement, followed by decarboxylation [2].
  • At pH 7.5 the concentration of this ion declines slowly, giving rise first to the N-hydroxyethyl derivative and then ultimately, following hydrolysis of the ester bond, to NN-bis(2-hydroxyethyl)propylamine and benzilic acid [3].

References

  1. Bromopropylate: induction of hepatic cytochromes P450 and absence of covalent binding to DNA in mouse liver. Thomas, H., Sagelsdorff, P., Molitor, E., Skripsky, T., Waechter, F. Toxicol. Appl. Pharmacol. (1994) [Pubmed]
  2. Influence of pyrolytic and aqueous-phase reactions on the mechanism of formation of Maillard products. Wnorowski, A., Yaylayan, V.A. J. Agric. Food Chem. (2000) [Pubmed]
  3. Pathways of decomposition of propylbenzilylcholine mustard in neutral and alkaline solution. Young, J.M. J. Pharm. Pharmacol. (1982) [Pubmed]
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