High impact information on ACAROL

• Immunochemical studies with monoclonal antibodies against rat liver cytochrome P450 isoenzymes of the gene families 1A, 2B, 3A, and 4A confirmed that bromopropylate is a phenobarbitone-type inducer in the mouse liver [1].
• Bromopropylate: induction of hepatic cytochromes P450 and absence of covalent binding to DNA in mouse liver [1].
• When compared with mice treated in parallel with the model compounds for hepatic xenobiotic metabolizing enzyme induction, phenobarbitone, and 3-methylcholanthrene, the enzyme activity changes observed with bromopropylate largely equalled those expressed in phenobarbitone-treated mice [1].
• Honey samples (101) from Galicia (N.W. Spain) were analyzed by gas chromatography (electron capture and flame ionization) for the presence of acaricides (amitraz, bromopropylate, coumaphos, and fluvalinate) [2].
• A multiresidue HPLC method for identification and quantification of the synthetic acaricides fluvalinate, coumaphos, bromopropylate and its metabolite 4,4'-dibromobenzophenone in beeswax has been developed [3].

Anatomical context of ACAROL

• The specific amplitude was increased 1.5-fold when microsomes from bromopropylate-treated mice (300 mg/kg body wt) were used instead of control microsomes, indicating the induction of cytochromes P450 catalyzing the oxidative metabolism of the test compound [1].

Gene context of ACAROL

• An analytical procedure is described for determination of residues of bromopropylate (BP) and its main degradation product 4,4'-dibromobenzophenone (BBP) in honey [4].

Analytical, diagnostic and therapeutic context of ACAROL

• Titration of liver microsomal suspensions with bromopropylate yielded Type I substrate binding spectra [1].
• Single oral administration of 300 mg/kg body wt [14C]bromopropylate to male mice, without or following pretreatment for 14 days with 300 mg/kg body wt unlabeled bromopropylate, gave no indication for DNA binding of the test compound in the liver [1].
• Determination of residual bromopropylate and coumaphos in honey and honeycomb by capillary gas chromatography [5].

References