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Chemical Compound Review:

Cyclam 1,4,8,11- tetrazacyclotetradecane

Synonyms: IPS2, SureCN33477, CHEMBL125150, AG-E-96251, CBDivE_013909, ...

Gerlach, L.O. et al., Thakur, M.L. et al., Nakayama, G.R. et al.

Thakur, Kolan, Li, Wiaderkiewicz, Pallela, Duggaraju, Schally,

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Disease relevance of Cyclam

The non-peptide CXCR4 receptor antagonist AMD3100, which is a potent blocker of human immunodeficiency virus cell entry, is a symmetrical bicyclam composed of two identical 1,4,8,11-tetraazacyclotetradecane (cyclam) moieties connected by a relatively rigid phenylenebismethylene linker [1].

High impact information on Cyclam

Vapreotide (RC-160), a somatostatin analog, was labeled with 99mTC by a direct method and also by using CPTA [1,4,8,11-tetraazacyclotetradecane] as a bifunctional chelating agent [2].
The binding site of the Fab fragment of antibody MOPC315 was chemically modified with cyclam (1,4,8,11-tetraazacyclotetradecane) and 1,10-phenanthroline [3].

References

Molecular interactions of cyclam and bicyclam non-peptide antagonists with the CXCR4 chemokine receptor. Gerlach, L.O., Skerlj, R.T., Bridger, G.J., Schwartz, T.W. J. Biol. Chem. (2001) [Pubmed]
Radiolabeled somatostatin analogs in prostate cancer. Thakur, M.L., Kolan, H., Li, J., Wiaderkiewicz, R., Pallela, V.R., Duggaraju, R., Schally, A.V. Nucl. Med. Biol. (1997) [Pubmed]
Approaches to the design of semisynthetic metal-dependent catalytic antibodies. Nakayama, G.R., Schultz, P.G. Ciba Found. Symp. (1991) [Pubmed]

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