Disease relevance of Cyclam

• The synthesis and radiolabeling of 2-nitroimidazole derivatives of cyclam and their preclinical evaluation as positive markers of tumor hypoxia [1].
• We have previously described the potent and selective inhibition of several strains of human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) by JM2763, an n-propyl-linked dimer of the 1,4,8,11-tetraazamacrocyclic (cyclam) ring system [2].

High impact information on Cyclam

• Understanding the factors which control the thermodynamics and kinetics of the interconversion of configurational states of metallo-cyclams may be a key factor in designing novel cyclam derivatives for future use in medicine [3].
• Molecular interactions of cyclam and bicyclam non-peptide antagonists with the CXCR4 chemokine receptor [4].
• These spectral similarities are shown to arise from the fact that 3 contains an alkyl thiolate tethered to the equatorial cyclam ring, resulting in a thiolate orientation that is very similar to the one adopted by the Cys residue in the SOR(red) active site [5].
• [structure: see text] Novel phenylazomethine dendrimers having a cyclam core were synthesized by the convergent method [6].
• Lipophilic derivatives of cyclam as new inhibitors of tumor cell growth [7].

Biological context of Cyclam

• Energy transfer from the lowest singlet and triplet excited states of the peripheral naphthyl units to the lower lying excited states of Nd3+, Eu3+, Tb3+, Dy3+ coordinated to the cyclam core does not take place [8].
• Hydrolysis of a coumarin ester substrate was catalysed by the Fab derivatized with a cyclam moiety with a kcat of 0.063 min-1 and Km of 11.7 microM; the presence of metal ions was not required for catalysis [9].

Associations of Cyclam with other chemical compounds

• Dendrimers as ligands: an investigation into the stability and kinetics of Zn2+ complexation by dendrimers with 1,4,8,11-tetraazacyclotetradecane (cyclam) cores [10].
• Cyclam NH hydrogen bonding is prevalent both in the solid state and in solution, and is relevant to the anti-HIV activity of Zn(II) and other metal cyclam complexes and to their ability to recognize the CXCR4 transmembrane co-receptor [11].
• Synthesis, characterization, and x-ray crystal structures of cyclam derivatives. 8. Thermodynamic and kinetic appraisal of lead(II) chelation by octadentate carbamoyl-armed macrocycles [12].
• Prompted by catalysis of CO2 electroreduction by a tetraazamacrocyclic Ni(i)(cyclam) complex (cyclam = 1,4,8,11-tetraazacyclotetradecane), we examine theoretically the possibility of H2 reduction by this molecule [13].

Gene context of Cyclam

• There was very little variation in the values of the Arrhenius preexponential factor between these three complexes, whereas the value of E(a) is 40.6 kJ/mol for the cyclam complex, 35.5 kJ/mol for the 1,11-C(3)-cyclam complex, and 22.3 kJ/mol for the 1,4-C(2)-cyclam complex [14].
• A survey of the CSD (crystallographic structural database) shows that the trans-III configuration is the most common in the solid state for complexes of cyclam itself [15].

Analytical, diagnostic and therapeutic context of Cyclam

• Coated-wire silver ion-selective electrode based on silver complex of cyclam [16].

References