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Chemical Compound Review:

Taractan (3Z)-3-(2-chlorothioxanthen- 9-ylidene)-N,N...

Synonyms: Iaractan, Rentovet, Tactaran, Vetacalm, Traquilan, ...

Roth, B.L. et al., Undén, M. et al.

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Disease relevance of Chlorprotixen

The neuroleptic, cis-chlorprothixene, is used extensively as a major tranquillizer but shares side-effects such as xerostomia with most antidepressants [1].

High impact information on Chlorprotixen

In addition, several typical antipsychotic agents (chloroprothixene, chlorpromazine, clothiapine and fluphenazine) had high affinities for both the 5-HT6 and 5-HT7 receptors [2].

References

Anticholinergic effects of cis-chlorprothixene characterized in rat parotid acini. Undén, M., Nauntofte, B., Dissing, S. Eur. J. Pharmacol. (1989) [Pubmed]
Binding of typical and atypical antipsychotic agents to 5-hydroxytryptamine-6 and 5-hydroxytryptamine-7 receptors. Roth, B.L., Craigo, S.C., Choudhary, M.S., Uluer, A., Monsma, F.J., Shen, Y., Meltzer, H.Y., Sibley, D.R. J. Pharmacol. Exp. Ther. (1994) [Pubmed]

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