Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Oestrasid 4-[(2E,4E)-4-(4- hydroxyphenyl)hexa-2,4...

Synonyms: Estroral, Sexadien, Teserene, Agaldog, Synestrol, ...

Pung, O.J. et al., Carter, A.P. et al., Li, J.J. et al., Schwartz, U. et al.

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High impact information on dienestrol

However, alpha -dienestrol and DES 3,4-oxide showed an 86 to 88% incidence of renal tumors in hamsters (approximately 10.8 +/- 3) [1].
Exposure to pharmacological concentrations of potent estrogenic compounds, including 17 beta-estradiol, diethylstilbestrol, and alpha-dienestrol, increased the susceptibility of mice to Toxoplasma gondii as measured by brain cyst formation [2].
The antibody cross-reacted with the stilbenes, diethylstilboestrol (10%) and dienoestrol (4%), but had no cross-reaction (less than 0.01%) with other anabolic agents [3].

Analytical, diagnostic and therapeutic context of dienestrol

Vaginal administration of dienoestrol cream (1 mg daily; n = 4) did not change TC-BC [4].

References

Relative carcinogenic activity of various synthetic and natural estrogens in the Syrian hamster kidney. Li, J.J., Li, S.A., Klicka, J.K., Parsons, J.A., Lam, L.K. Cancer Res. (1983) [Pubmed]
Toxoplasma gondii: decreased resistance to infection in mice due to estrogen. Pung, O.J., Luster, M.I. Exp. Parasitol. (1986) [Pubmed]
An improved radioimmunoassay for the anabolic agent hexoestrol, using a monoclonal antibody. Carter, A.P., Cottingham, J.D., Dixon, S.N., Heitzman, R.J. J. Vet. Pharmacol. Ther. (1985) [Pubmed]
Effects of various replacement oestrogens on hepatic transcortin synthesis in climacteric women. Schwartz, U., Volger, H., Schneller, E., Moltz, L., Hammerstein, J. Acta Endocrinol. (1983) [Pubmed]

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