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Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Administration, Intravaginal

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Disease relevance of Administration, Intravaginal


High impact information on Administration, Intravaginal


Chemical compound and disease context of Administration, Intravaginal


Biological context of Administration, Intravaginal


Anatomical context of Administration, Intravaginal

  • Yet, the actual mechanisms by which vaginal administration of progesterone can induce higher concentrations in the uterus, despite low concentrations in the systemic circulation, remain obscure and most puzzling to many gynaecologists [21].
  • CONCLUSIONS: The daily vaginal administration of one vial of micronized P for 10 days allowed useful serum P levels to be reached, especially after estrogen therapy, and induced clear secretory changes in the endometrium [18].
  • CONCLUSIONS: Vaginal administration of misoprostol (Cytotec) is an effective alternative to oxytocin infusion for labor induction in women with premature rupture of the membranes near term [22].
  • In each side, the ovarian and uterine arteries form arterial anastomoses and controversy exists regarding the origin of the arterial supply to the Fallopian tube and tubal part of the uterus, and consequently whether these tissues can be reached through vaginal administration [23].
  • The pregnancy was terminated by vaginal administration of misoprostol, and postmortem examination confirmed the ultrasound findings, including bilateral upper limb reduction with radial aplasia, absent first metacarpal and thumb and ventrally hyperflexed hands [24].

Associations of Administration, Intravaginal with chemical compounds


Gene context of Administration, Intravaginal


Analytical, diagnostic and therapeutic context of Administration, Intravaginal


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  17. The effect of vaginal administration of various doses of prostaglandin E2 gel on cervical ripening and induction of labor. Graves, G.R., Baskett, T.F., Gray, J.H., Luther, E.R. Am. J. Obstet. Gynecol. (1985) [Pubmed]
  18. Pharmacokinetics and endometrial effects of the vaginal administration of micronized progesterone in an oil-based solution to postmenopausal women. Cicinelli, E., Borraccino, V., Petruzzi, D., Mazzotta, N., Cerundolo, M.L., Schönauer, L.M. Fertil. Steril. (1996) [Pubmed]
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  20. Vaginal absorption of insulin in the rat: effect of penetration enhancers on insulin uptake and mucosal histology. Richardson, J.L., Illum, L., Thomas, N.W. Pharm. Res. (1992) [Pubmed]
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  22. Induction of labor with misoprostol for premature rupture of membranes beyond thirty-six weeks' gestation. Wing, D.A., Paul, R.H. Am. J. Obstet. Gynecol. (1998) [Pubmed]
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  28. Absorption and metabolism of nafarelin, a potent agonist of gonadotropin-releasing hormone. Chan, R.L., Henzl, M.R., LePage, M.E., LaFargue, J., Nerenberg, C.A., Anik, S., Chaplin, M.D. Clin. Pharmacol. Ther. (1988) [Pubmed]
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  33. A medical method of early pregnancy termination using tamoxifen and misoprostol. Mishell, D.R., Jain, J.K., Byrne, J.D., Lacarra, M.D. Contraception. (1998) [Pubmed]
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  37. Mid-trimester abortion induced by intravaginal administration of prostaglandin E2 suppositories. Lauersen, N.H., Secher, N.J., Wilson, K.H. Am. J. Obstet. Gynecol. (1975) [Pubmed]
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