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Chemical Compound Review:

A201_ALDRICH acenaphthene-1,2-dione

Synonyms: CHEMBL395653, SureCN141538, NSC-7656, CCRIS 5318, AG-C-90081, ...

Pothuluri, J.V. et al., Chung, S.W. et al.

Chung, Chung, Toriba, Kameda, Tang, Kizu, Hayakawa,

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High impact information on NSC7656

Seven metabolites were identified by 1H nuclear magnetic resonance, UV, and mass spectral techniques as 6-hydroxyacenaphthenone (24.8%), 1,2-acenaphthenedione (19.9%), trans-1,2-dihydroxyacenaphthene (10.3%), 1,5-dihydroxyacenaphthene (2.7%), 1-acenaphthenol (2.4%), 1-acenaphthenone (2.1%), and cis-1,2-dihydroxyacenaphthene (1.8%) [1].
We found that both acenaphthenequinone (AcQ) and 9,10-phenanthrenequinone (PQ) enhanced ROS generation and that AcQ translocated NF-kappaB from the cytosol to the nucleus [2].

References

Fungal metabolism of acenaphthene by Cunninghamella elegans. Pothuluri, J.V., Freeman, J.P., Evans, F.E., Cerniglia, C.E. Appl. Environ. Microbiol. (1992) [Pubmed]
An Environmental Quinoid Polycyclic Aromatic Hydrocarbon, Acenaphthenequinone, Modulates Cyclooxygenase-2 Expression through Reactive Oxygen Species Generation and Nuclear Factor Kappa B Activation in A549 Cells. Chung, S.W., Chung, H.Y., Toriba, A., Kameda, T., Tang, N., Kizu, R., Hayakawa, K. Toxicol. Sci. (2007) [Pubmed]

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