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Chemical Compound Review

CHEMBL51931     phenanthrene-9,10-dione

Synonyms: SureCN43050, NSC-7389, CCRIS 7615, ACMC-20977q, CHEBI:37454, ...
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Disease relevance of NSC7389


High impact information on NSC7389

  • 9,10-Phenanthraquinone in diesel exhaust particles downregulates Cu,Zn-SOD and HO-1 in human pulmonary epithelial cells: intracellular iron scavenger 1,10-phenanthroline affords protection against apoptosis [6].
  • The enantiomers of the symmetric metallointercalator complex 1-Rh(MGP)2phi5+ [MGP = 4-(guanidylmethyl)-1,10-phenanthroline; phi = phenanthrenequinone diimine] bound to DNA decamer duplexes containing their respective 6 bp recognition sequences have been investigated using 1H NMR [7].
  • The three-dimensional folding of Xenopus oocyte 5S rRNA has been examined using the coordination complex Rh(phen)2phi3+ (phen = phenanthroline; phi = phenanthrenequinone diimine) as a structural probe [8].
  • Guanidino compounds in CSF of 57 human subjects were determined fluorometrically after reaction with phenanthrenequinone in alkali solution, using HPLC [9].
  • PHCR has the ability to catalyze efficiently the reduction of 9,10-phenanthrenequinone (PQ) contained in diesel exhaust particles (DEPs) [10].

Chemical compound and disease context of NSC7389


Biological context of NSC7389


Anatomical context of NSC7389


Associations of NSC7389 with other chemical compounds


Gene context of NSC7389


Analytical, diagnostic and therapeutic context of NSC7389


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  3. An examination of quinone toxicity using the yeast Saccharomyces cerevisiae model system. Rodriguez, C.E., Shinyashiki, M., Froines, J., Yu, R.C., Fukuto, J.M., Cho, A.K. Toxicology (2004) [Pubmed]
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  6. 9,10-Phenanthraquinone in diesel exhaust particles downregulates Cu,Zn-SOD and HO-1 in human pulmonary epithelial cells: intracellular iron scavenger 1,10-phenanthroline affords protection against apoptosis. Sugimoto, R., Kumagai, Y., Nakai, Y., Ishii, T. Free Radic. Biol. Med. (2005) [Pubmed]
  7. Differential DNA recognition by the enantiomers of 1-Rh(MGP)2 phi: a combination of shape selection and direct readout. Franklin, S.J., Barton, J.K. Biochemistry (1998) [Pubmed]
  8. Delineation of structural domains in eukaryotic 5S rRNA with a rhodium probe. Chow, C.S., Hartmann, K.M., Rawlings, S.L., Huber, P.W., Barton, J.K. Biochemistry (1992) [Pubmed]
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  10. 9,10-phenanthrenequinone, a component of diesel exhaust particles, inhibits the reduction of 4-benzoylpyridine and all-trans-retinal and mediates superoxide formation through its redox cycling in pig heart. Shimada, H., Oginuma, M., Hara, A., Imamura, Y. Chem. Res. Toxicol. (2004) [Pubmed]
  11. Assessment of the toxicity of mixtures of copper, 9,10-phenanthrenequinone, and phenanthrene to Daphnia magna: evidence for a reactive oxygen mechanism. Xie, F., Koziar, S.A., Lampi, M.A., Dixon, D.G., Warren, N.P., Borgmann, U., Huang, X.D., Greenberg, B.M. Environ. Toxicol. Chem. (2006) [Pubmed]
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  13. Inhibition of camel lens zeta-crystallin by aspirin and aspirin-like analgesics. Bazzi, M.D., Rabbani, N., Duhaiman, A.S. Int. J. Biochem. Cell Biol. (2002) [Pubmed]
  14. Phenanthraquinone inhibits eNOS activity and suppresses vasorelaxation. Kumagai, Y., Hayashi, T., Miyauchi, T., Endo, A., Iguchi, A., Kiriya-Sakai, M., Sakai, S., Yuki, K., Kikushima, M., Shimojo, N. Am. J. Physiol. Regul. Integr. Comp. Physiol. (2001) [Pubmed]
  15. Studies on three reductases which have polycyclic aromatic hydrocarbon quinones as substrates. Jarabak, J., Harvey, R.G. Arch. Biochem. Biophys. (1993) [Pubmed]
  16. Oxidation of proximal protein sulfhydryls by phenanthraquinone, a component of diesel exhaust particles. Kumagai, Y., Koide, S., Taguchi, K., Endo, A., Nakai, Y., Yoshikawa, T., Shimojo, N. Chem. Res. Toxicol. (2002) [Pubmed]
  17. An Environmental Quinoid Polycyclic Aromatic Hydrocarbon, Acenaphthenequinone, Modulates Cyclooxygenase-2 Expression through Reactive Oxygen Species Generation and Nuclear Factor Kappa B Activation in A549 Cells. Chung, S.W., Chung, H.Y., Toriba, A., Kameda, T., Tang, N., Kizu, R., Hayakawa, K. Toxicol. Sci. (2007) [Pubmed]
  18. Effects of a single intratracheal administration of phenanthraquinone on murine lung. Hiyoshi, K., Takano, H., Inoue, K., Ichinose, T., Yanagisawa, R., Tomura, S., Cho, A.K., Froines, J.R., Kumagai, Y. Journal of applied toxicology : JAT. (2005) [Pubmed]
  19. Substrate specificity of mouse aldo-keto reductase AKR7A5. Hinshelwood, A., McGarvie, G., Ellis, E.M. Chem. Biol. Interact. (2003) [Pubmed]
  20. Fluorescence histochemistry of peptide hormone-producing cells: observations on the phenanthrenequinone method for the demonstration of arginine residues. Sundler, F., Håkanson, R. Histochemistry (1978) [Pubmed]
  21. Kinetic properties of camel lens zeta-crystallin. Duhaiman, A.S. Int. J. Biochem. Cell Biol. (1996) [Pubmed]
  22. Effects of quinones and flavonoids on the reduction of all-trans retinal to all-trans retinol in pig heart. Shimada, H., Hirashima, T., Imamura, Y. Eur. J. Pharmacol. (2006) [Pubmed]
  23. Bulbophyllanthrone: A Cytotoxic Phenanthraquinone from the New Zealand Orchid, Earino autumnalis. Hinkley, S.F., Lorimer, S.D. Planta Med. (1999) [Pubmed]
  24. Dihydrodiol dehydrogenase activities of rabbit liver are associated with hydroxysteroid dehydrogenases and aldo-keto reductases. Klein, J., Thomas, H., Post, K., Wörner, W., Oesch, F. Eur. J. Biochem. (1992) [Pubmed]
  25. Two polycyclic aromatic hydrocarbon o-quinone reductases from a pyrene-degrading Mycobacterium. Kim, Y.H., Engesser, K.H., Cerniglia, C.E. Arch. Biochem. Biophys. (2003) [Pubmed]
  26. Characterization of a major form of human isatin reductase and the reduced metabolite. Usami, N., Kitahara, K., Ishikura, S., Nagano, M., Sakai, S., Hara, A. Eur. J. Biochem. (2001) [Pubmed]
  27. Formation of guanidinosuccinic acid, a stable nitric oxide mimic, from argininosuccinic acid and nitric oxide-derived free radicals. Aoyagi, K., Akiyama, K., Shahrzad, S., Tomida, C., Hirayama, A., Nagase, S., Takemura, K., Koyama, A., Ohba, S., Narita, M. Free Radic. Res. (1999) [Pubmed]
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  29. The role of protein kinase C in the increased generation in isolated rat hepatocytes of the hydroxyl radical by puromycin aminonucleoside. Aoyagi, K., Shahrzad, S., Kuzure, Y., Koyama, A., Nakamura, K., Ienaga, K. Free Radic. Res. (2000) [Pubmed]
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