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Chemical Compound Review:

PubChem8223 2,4-dinitrobenzaldehyde

Synonyms: CCRIS 2684, AG-F-80739, ACMC-209l2f, ANW-31573, NSC-36948, ...

Mori, M.A. et al., Moriuchi, T. et al., Shoji, M. et al., Sayama, M. et al.

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Disease relevance of NSC 36948

2,4-Dinitrotoluene (2,4-DNT) and its metabolites (2A4NT, 4A2NT, 2,4-DNB, 2A4NB, 4A2NB, 2,4-DAT, 2N4AAT, 2A4AAT, 2A4AABA and 2,4-DNBA), and 2,4-dinitrobenzaldehyde (2,4-DNA1), putative metabolite of 2,4-DNT, were tested for mutagenicity in Salmonella typhimurium strains TA98 and TA100 [1].

High impact information on NSC 36948

Enterohepatic circulation of 2,4-dinitrobenzaldehyde, a mutagenic metabolite of 2,4-dinitrotoluene, in male Wistar rat [2].
Metabolism of 2,4-dinitrotoluene, 2,4-dinitrobenzyl alcohol and 2,4-dinitrobenzaldehyde by rat liver microsomal and cytosol fractions [3].

Analytical, diagnostic and therapeutic context of NSC 36948

DNA fragments were labeled with dinitrophenyl (DNP) residues by the reaction with 2,4-dinitrobenzaldehyde in alkaline condition and the labeled DNA was used as a probe for non-radioactive in situ hybridization [4].

References

Mutagenicity of 2,4-dinitrotoluene and its metabolites in Salmonella typhimurium. Mori, M.A., Miyahara, T., Taniguchi, K., Hasegawa, K., Kozuka, H., Miyagoshi, M., Nagayama, T. Toxicol. Lett. (1982) [Pubmed]
Enterohepatic circulation of 2,4-dinitrobenzaldehyde, a mutagenic metabolite of 2,4-dinitrotoluene, in male Wistar rat. Sayama, M., Mori, M., Ishida, M., Okumura, K., Kozuka, H. Xenobiotica (1989) [Pubmed]
Metabolism of 2,4-dinitrotoluene, 2,4-dinitrobenzyl alcohol and 2,4-dinitrobenzaldehyde by rat liver microsomal and cytosol fractions. Shoji, M., Mori, M., Kawajiri, T., Sayama, M., Mori, Y., Miyahara, T., Honda, T., Kozuka, H. Chem. Pharm. Bull. (1987) [Pubmed]
Use of non-radioactive DNA probes for the characterization of adult T-cell leukemia cells. Moriuchi, T., Koji, T., Nakane, P.K., Yoshida, M., Moriuchi, J., Arimori, S. Nucleic Acids Symp. Ser. (1988) [Pubmed]

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