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Chemical Compound Review:

CHEMBL375600 1,2,3,4,5,6-hexabromobenzene

Synonyms: CCRIS 5917, AG-H-54366, ACMC-20aj0o, ANW-75574, HSDB 2912, ...

Villeneuve, D.C. et al., Koss, G. et al., Zhang, Q. et al., Mendoza, C.E. et al., Frydrych, B. et al., et al.

Zhang, Matsumoto, Saito, Baron,

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Disease relevance of HSDB 2912

To study the metabolic fate of hexabromobenzene (HBB) in female rats, the substance was administered in oral doses of 16.6 mg/kg body weight every other day for 2 weeks and the animals' excreta were examined for metabolites [1].
Unlike the highly porphyrinogenic fungicide hexachlorobenzene, hexabromobenzene was a poor inducer of porphyria [2].

High impact information on HSDB 2912

A hexabromobenzene (HBB, C6Br6) powder was subjected to co-grinding with excess CaO powder in air using a planetary ball mill to investigate mechanochemical debromination of the HBB sample [3].
Tissue distribution and excretion of hexabromobenzene and its debrominated metabolites in the rat [4].
Effects of hexachlorobenzene or hexabromobenzene on body and organ weights of preweanling rats after a reciprocal transfer between the treated and control dams [5].
In our study we attempted to assess the effect of hexabromobenzene (HBB) and its metabolites on the level of GSH and related enzymes, GPx and GST [6].
With hexabromobenzene, the greatest accumulation was observed in adipose tissue, followed by spleen, liver, heart, kidney and brain [7].

Biological context of HSDB 2912

Pentachloro-, pentachloronitro-, and hexabromobenzene were administered per os to rats daily on days 6 through 15 of gestation at level of 40, 100, and 200 mg/kg body weight [7].

Analytical, diagnostic and therapeutic context of HSDB 2912

Determination of hexabromobenzene in rat tissues by gas-liquid chromatography [8].

References

Metabolic fate of hexabromobenzene in rats. Koss, G., Döring, H., Würminghausen, B., Koransky, W. Toxicol. Lett. (1982) [Pubmed]
Brominated benzene induction of hepatic porphyria. Carlson, G.P. Experientia (1979) [Pubmed]
Debromination of hexabromobenzene by its co-grinding with CaO. Zhang, Q., Matsumoto, H., Saito, F., Baron, M. Chemosphere (2002) [Pubmed]
Tissue distribution and excretion of hexabromobenzene and its debrominated metabolites in the rat. Yamaguchi, Y., Kawano, M., Tatsukawa, R. Arch. Environ. Contam. Toxicol. (1988) [Pubmed]
Effects of hexachlorobenzene or hexabromobenzene on body and organ weights of preweanling rats after a reciprocal transfer between the treated and control dams. Mendoza, C.E., Collins, B.T., Shields, J.B., Laver, G.W. J. Agric. Food Chem. (1978) [Pubmed]
The effect of selected aromatic bromine derivatives on the activity of glutathione peroxidase and transferase. Frydrych, B., Szymańska, J.A., Sala, M., Bruchajzer, E. International journal of occupational medicine and environmental health. (2005) [Pubmed]
Placental transfer of halogenated benzenes (pentachloro-, pentachloronitro-, and hexabromo-) in rats. Villeneuve, D.C., Khera, K.S. Environmental physiology & biochemistry. (1975) [Pubmed]
Determination of hexabromobenzene in rat tissues by gas-liquid chromatography. Mendoza, C.E., Laver, G.W. J. Agric. Food Chem. (1977) [Pubmed]

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