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Chemical Compound Review

Leucinamide     (2S)-2-amino-4-methyl- pentanamide

Synonyms: L-LEUCINAMIDE, PubChem13171, CHEMBL598548, AG-K-71567, CHEBI:41592, ...
 
 
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Disease relevance of Leucinamide

 

High impact information on Leucinamide

  • The oral delivery of O-(N-morpholino-carbonyl-3-L-phenylaspartyl-L- leucinamide of (2S,3R,4S)-2-amino-1-cyclohexyl-3,4-dihydroxy-6-methylhetane (I), a new renin inhibitor, was studied in the in vivo rat model using emulsion formulations [2].
  • Because of its ability to cleave leucinamide, its high pH optimum, and its Mn2+ dependence, it can be classified as a leucine aminopeptidase (LAP) [3].
  • Studies of the clinical application of serum leucine aminopeptidase (LAP) activity determined with leucinamide as substrate [4].

References

  1. Effect of L-leucinamide hydrochloride on experimental inflammation. Madan, B.R., Al-Motrefi, A. Res. Commun. Chem. Pathol. Pharmacol. (1987) [Pubmed]
  2. Oral delivery of a renin inhibitor compound using emulsion formulations. Kararli, T.T., Needham, T.E., Griffin, M., Schoenhard, G., Ferro, L.J., Alcorn, L. Pharm. Res. (1992) [Pubmed]
  3. Degradation of prolylleucylglycinamide (MIF) by mouse brain. Neidle, A., Yessaian, N., Lajtha, A. Neurochem. Res. (1980) [Pubmed]
  4. Studies of the clinical application of serum leucine aminopeptidase (LAP) activity determined with leucinamide as substrate. Ito, S., Takaoka, T., Kishi, S., Okuda, H., Fujii, S. Gastroenterol. Jpn. (1975) [Pubmed]
 
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