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MeSH Review

Stomach Ulcer

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Disease relevance of Stomach Ulcer


Psychiatry related information on Stomach Ulcer


High impact information on Stomach Ulcer


Chemical compound and disease context of Stomach Ulcer

  • In patients with H. pylori infection and gastric ulcers unrelated to the use of nonsteroidal antiinflammatory drugs, one week of antibacterial therapy without acid suppression heals the ulcers as well as omeprazole and reduces the rate of their recurrence [15].
  • These drugs also show synergism with either amoxicillin or clari- thromycin in eradicating Helicobacter pylori, an organism shown to be important in duodenal and gastric ulcer disease [16].
  • METHODS: Gastric ulcers were induced in rats by acetic acid applied to the serosal surface of the stomach, and the site around the ulcer was injected with nonviral plasmid-encoding full-length complementary DNA (cDNA) of human recombinant (rh) VEGF165, rhAng1, or their combination [17].
  • Repeated administration of indomethacin markedly delays spontaneous healing of experimental gastric ulcers induced in rats [18].
  • Sucralfate appears useful for duodenal but not gastric ulcers [19].

Biological context of Stomach Ulcer


Anatomical context of Stomach Ulcer


Gene context of Stomach Ulcer


Analytical, diagnostic and therapeutic context of Stomach Ulcer


  1. Mice deficient in protein tyrosine phosphatase receptor type Z are resistant to gastric ulcer induction by VacA of Helicobacter pylori. Fujikawa, A., Shirasaka, D., Yamamoto, S., Ota, H., Yahiro, K., Fukada, M., Shintani, T., Wada, A., Aoyama, N., Hirayama, T., Fukamachi, H., Noda, M. Nat. Genet. (2003) [Pubmed]
  2. Cost-effectiveness of cimetidine maintenance therapy in chronic gastric and duodenal ulcer. Pym, B., Sandstad, J., Seville, P., Byth, K., Middleton, W.R., Talley, N.J., Piper, D.W. Gastroenterology (1990) [Pubmed]
  3. Progression of fundal gastritis in gastric ulcer patients. Maaroos, H.I., Salupere, V., Uibo, R., Kekki, M., Sipponen, P. Gastroenterology (1986) [Pubmed]
  4. Krebs cycle, pentose phosphate pathway, and glycolysis in the uninvolved gastric mucosa of peptic ulcer and gastric cancer patients. Orwell, R.L., Piper, D.W. Gastroenterology (1977) [Pubmed]
  5. Prevention of gastroduodenal injury induced by chronic nonsteroidal antiinflammatory drug therapy. Graham, D.Y. Gastroenterology (1989) [Pubmed]
  6. Clinical efficacy of sucralfate in the treatment of gastric ulcer. Asaka, M., Takeda, H., Saito, M., Murashima, Y., Miyazaki, T. Am. J. Med. (1991) [Pubmed]
  7. Effects of 4-acetylpyridine on stress ulcer formation in mice. Hall, A., Bose, R., Glavin, G., Pinsky, C. Neurosci. Lett. (1988) [Pubmed]
  8. The personality pattern of patients with chronic peptic ulcer. A case-control study. McIntosh, J.H., Nasiry, R.W., Frydman, M., Waller, S.L., Piper, D.W. Scand. J. Gastroenterol. (1983) [Pubmed]
  9. Non-steroidal anti-inflammatory drug gastropathy: clinical results with misoprostol. Koch, M. Italian journal of gastroenterology and hepatology. (1999) [Pubmed]
  10. Experimental study on bromopride pharmacology in vivo. antiemetic activity, effects on intestinal transit, on bloating and on gastric ulcers; basal effects on CNS and interferences with the spontaneous motor activity. Giordano, L., Visone, C., Rosatti, R., Di Mezza, G., Montanino, C., Turtur, A., Losanna Cannavacciuolo, G. Agressologie (1980) [Pubmed]
  11. Omeprazole compared with misoprostol for ulcers associated with nonsteroidal antiinflammatory drugs. Omeprazole versus Misoprostol for NSAID-induced Ulcer Management (OMNIUM) Study Group. Hawkey, C.J., Karrasch, J.A., Szczepañski, L., Walker, D.G., Barkun, A., Swannell, A.J., Yeomans, N.D. N. Engl. J. Med. (1998) [Pubmed]
  12. Prozac or prilosec for gastric ulcer? Costable, J.M., McKinley, M.J. N. Engl. J. Med. (1996) [Pubmed]
  13. Famotidine for the prevention of gastric and duodenal ulcers caused by nonsteroidal antiinflammatory drugs. Taha, A.S., Hudson, N., Hawkey, C.J., Swannell, A.J., Trye, P.N., Cottrell, J., Mann, S.G., Simon, T.J., Sturrock, R.D., Russell, R.I. N. Engl. J. Med. (1996) [Pubmed]
  14. Cimetidine for benign gastric ulcer. McKegney, F.P. N. Engl. J. Med. (1983) [Pubmed]
  15. Antibacterial treatment of gastric ulcers associated with Helicobacter pylori. Sung, J.J., Chung, S.C., Ling, T.K., Yung, M.Y., Leung, V.K., Ng, E.K., Li, M.K., Cheng, A.F., Li, A.K. N. Engl. J. Med. (1995) [Pubmed]
  16. The pharmacology of the gastric acid pump: the H+,K+ ATPase. Sachs, G., Shin, J.M., Briving, C., Wallmark, B., Hersey, S. Annu. Rev. Pharmacol. Toxicol. (1995) [Pubmed]
  17. Gene therapy for gastric ulcers with single local injection of naked DNA encoding VEGF and angiopoietin-1. Jones, M.K., Kawanaka, H., Baatar, D., Szabó, I.L., Tsugawa, K., Pai, R., Koh, G.Y., Kim, I., Sarfeh, I.J., Tarnawski, A.S. Gastroenterology (2001) [Pubmed]
  18. Effect of indomethacin on gastric mucosal blood flow around acetic acid-induced gastric ulcers in rats. Hirose, H., Takeuchi, K., Okabe, S. Gastroenterology (1991) [Pubmed]
  19. Nonsteroidal antiinflammatory drug-induced ulcers: management by traditional therapies. McCarthy, D.M. Gastroenterology (1989) [Pubmed]
  20. Expression of functional neurokinin-1 receptors in regenerative glands during gastric wound healing in rodents. Schmassmann, A., Waser, B., Flogerzi, B., Reubi, J.C. Gastroenterology (2004) [Pubmed]
  21. Inhibitory effect of non-steroidal anti-inflammatory drugs on mucosal cell proliferation associated with gastric ulcer healing. Levi, S., Goodlad, R.A., Lee, C.Y., Stamp, G., Walport, M.J., Wright, N.A., Hodgson, H.J. Lancet (1990) [Pubmed]
  22. Induction of mitogen-activated protein kinase signal transduction pathway during gastric ulcer healing in rats. Pai, R., Ohta, M., Itani, R.M., Sarfeh, I.J., Tarnawski, A.S. Gastroenterology (1998) [Pubmed]
  23. Pepsinogen C gene polymorphisms associated with gastric body ulcer. Azuma, T., Teramae, N., Hayakumo, T., Yasuda, K., Nakajima, M., Kodama, T., Inokuchi, H., Hayashi, K., Taggart, R.T., Kawai, K. Gut (1993) [Pubmed]
  24. Localization of syndecan-1 in human gastric mucosa associated with ulceration. Tanabe, H., Yokota, K., Kohgo, Y. J. Pathol. (1999) [Pubmed]
  25. Importance of gastric acid in gastric ulcer formation in rabbits with antibody-induced prostaglandin deficiency. Lee, M., Aldred, K., Lee, E., Prince, M.D., Feldman, M. Gastroenterology (1992) [Pubmed]
  26. Influence of prostaglandins, omeprazole, and indomethacin on healing of experimental gastric ulcers in the rat. Inauen, W., Wyss, P.A., Kayser, S., Baumgartner, A., Schürer-Maly, C.C., Koelz, H.R., Halter, F. Gastroenterology (1988) [Pubmed]
  27. Gastric mucosal prostaglandin E levels in patients with gastric ulcer disease and carcinoma. Wright, J.P., Young, G.O., Klaff, L.J., Weers, L.A., Price, S.K., Marks, I.N. Gastroenterology (1982) [Pubmed]
  28. "Melanosis" of the duodenum associated with a gastric ulcer and folic acid deficiency. Sharp, J.R., Insalaco, S.J., Johnson, L.F. Gastroenterology (1980) [Pubmed]
  29. Comparative efficacy of cimetidine, famotidine, ranitidine, and mylanta in postoperative stress ulcers. Gastric pH control and ulcer prevention in patients undergoing coronary artery bypass graft surgery. Lamothe, P.H., Rao, E., Serra, A.J., Castellano, J., Woronick, C.L., McNicholas, K.W., Lemole, G.M. Gastroenterology (1991) [Pubmed]
  30. Proteinase-activated receptors 1 and 4 counter-regulate endostatin and VEGF release from human platelets. Ma, L., Perini, R., McKnight, W., Dicay, M., Klein, A., Hollenberg, M.D., Wallace, J.L. Proc. Natl. Acad. Sci. U.S.A. (2005) [Pubmed]
  31. Effects of disruption of the plasminogen gene on thrombosis, growth, and health in mice. Ploplis, V.A., Carmeliet, P., Vazirzadeh, S., Van Vlaenderen, I., Moons, L., Plow, E.F., Collen, D. Circulation (1995) [Pubmed]
  32. Activation of Raf-1 during experimental gastric ulcer healing is Ras-mediated and protein kinase C-independent. Pai, R., Jones, M.K., Tomikawa, M., Tarnawski, A.S. Am. J. Pathol. (1999) [Pubmed]
  33. Cimetidine, antacid, and hospitalization in the treatment of benign gastric ulcer: a multicenter double blind study. Englert, E., Freston, J.W., Graham, D.Y., Finkelstein, W., Kruss, D.M., Priest, R.J., Raskin, J.B., Rhodes, J.B., Rogers, A.I., Wenger, J., Wilcox, L.L., Crossley, R.J. Gastroenterology (1978) [Pubmed]
  34. Gastrointestinal ulcer formation in rabbits immunized with prostaglandin E2. Redfern, J.S., Blair, A.J., Lee, E., Feldman, M. Gastroenterology (1987) [Pubmed]
  35. Serum response factor promotes re-epithelialization and muscular structure restoration during gastric ulcer healing. Chai, J., Baatar, D., Tarnawski, A. Gastroenterology (2004) [Pubmed]
  36. Misoprostol compared with sucralfate in the prevention of nonsteroidal anti-inflammatory drug-induced gastric ulcer. A randomized, controlled trial. Agrawal, N.M., Roth, S., Graham, D.Y., White, R.H., Germain, B., Brown, J.A., Stromatt, S.C. Ann. Intern. Med. (1991) [Pubmed]
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