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Gene Review

Lap3  -  leucine aminopeptidase 3

Mus musculus

Synonyms: 2410015L10Rik, AA410100, Cytosol aminopeptidase, LAP, LAP-3, ...
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Disease relevance of Lap3

  • The activities of 5'-nucleotidase and leucine aminopeptidase in the cultured granuloma cells showed that they resembled macrophages from thioglycollate-stimulated mice but not unstimulated macrophages in these respects [1].
  • Adipocyte-derived leucine aminopeptidase suppresses angiogenesis in human endometrial carcinoma via renin-angiotensin system [2].
  • Analysis of differentiating cells from primary melanomas in culture revealed a flat, fibroblast-like morphology and expression of the fibroblast-associated marker leucine aminopeptidase (LAP) [3].
  • Bestatin, which inhibited aminopeptidase B and leucine aminopeptidase, enhanced delayed-type hypersensitivity in a wide range of its low dosis (0.1-100 micrometer/mouse) and produced an immune resistance to the second inoculation of the same tumor cells [4].

High impact information on Lap3


Biological context of Lap3


Anatomical context of Lap3


Associations of Lap3 with chemical compounds


Other interactions of Lap3


Analytical, diagnostic and therapeutic context of Lap3


  1. Mononuclear phagocytes from carrageenan-induce granulomas. Isolation, cultivation, and characterization. Bonney, R.J., Gery, I., Lin, T.Y., Meyenhofer, M.F., Acevedo, W., Davies, P. J. Exp. Med. (1978) [Pubmed]
  2. Adipocyte-derived leucine aminopeptidase suppresses angiogenesis in human endometrial carcinoma via renin-angiotensin system. Watanabe, Y., Shibata, K., Kikkawa, F., Kajiyama, H., Ino, K., Hattori, A., Tsujimoto, M., Mizutani, S. Clin. Cancer Res. (2003) [Pubmed]
  3. Spontaneous and induced differentiation of human melanoma cells. Valyi-Nagy, I., Shih, I.M., Györfi, T., Greenstein, D., Juhasz, I., Elder, D.E., Herlyn, M. Int. J. Cancer (1993) [Pubmed]
  4. Small molecular microbial products enhancing immune response. Umezawa, H. Antibiotics and chemotherapy. (1978) [Pubmed]
  5. Histochemical patterns in early lesions and infiltrating adenocarcinomas induced in mouse duodenum by n-ethyl-n'-nitro-n-nitrosoguanidine. Matsuyama, M., Ito, M., Yamada, S., Nakamura, T., Nagayo, T. J. Natl. Cancer Inst. (1976) [Pubmed]
  6. Redistribution of membrane proteins in isolated mouse intestinal epithelial cells. Ziomek, C.A., Schulman, S., Edidin, M. J. Cell Biol. (1980) [Pubmed]
  7. [mono[125I]iodo-Tyr10,MetO17]-vasoactive intestinal polypeptide. Preparation, characterization, and use for radioimmunoassay and receptor binding. Martin, J.L., Rose, K., Hughes, G.J., Magistretti, P.J. J. Biol. Chem. (1986) [Pubmed]
  8. Tumor-associated macrophages of mouse mammary tumors. II. Differential distribution of macrophages from metastatic and nonmetastatic tumors. Mahoney, K.H., Fulton, A.M., Heppner, G.H. J. Immunol. (1983) [Pubmed]
  9. Changes in macrophage ectoenzymes associated with anti-tumor activity. Morahan, P.S., Edelson, P.J., Gass, K. J. Immunol. (1980) [Pubmed]
  10. Linkage relationships of peptidase-7, Pep-7, in the mouse. Peters, J., Povey, S., Jeremiah, S., De Giorgi, L. Biochem. Genet. (1983) [Pubmed]
  11. Proteases in the Emory mouse cataract. Swanson, A.A., Davis, R.M., Meinhardt, N.C., Kuck, K.D., Kuck, J.F. Invest. Ophthalmol. Vis. Sci. (1985) [Pubmed]
  12. Isoenzyme diversity in Pneumocystis carinii from rats, mice, and rabbits. Mazars, E., Guyot, K., Durand, I., Dei-Cas, E., Boucher, S., Abderrazak, S.B., Banuls, A.L., Tibayrenc, M., Camus, D. J. Infect. Dis. (1997) [Pubmed]
  13. Tissue distribution of placental leucine aminopeptidase/oxytocinase during mouse pregnancy. Kobayashi, H., Nomura, S., Mitsui, T., Ito, T., Kuno, N., Ohno, Y., Kadomatsu, K., Muramatsu, T., Nagasaka, T., Mizutani, S. J. Histochem. Cytochem. (2004) [Pubmed]
  14. Differential effects of chronic monocyte depletion on macrophage populations. Volkman, A., Chang, N.C., Strausbauch, P.H., Morahan, P.S. Lab. Invest. (1983) [Pubmed]
  15. Identification and properties of the cell membrane bound leucine aminopeptidase interacting with the potential immunostimulant and chemotherapeutic agent bestatin. Leyhausen, G., Schuster, D.K., Vaith, P., Zahn, R.K., Umezawa, H., Falke, D., Müller, W.E. Biochem. Pharmacol. (1983) [Pubmed]
  16. Protective efficacy of trypsin inhibitor on the the gut following rotavirus infection in malnourished infant mice. Katyal, R., Ojha, S., Rana, S.V., Vaiphie, K., Singh, K., Singh, V. Ann. Nutr. Metab. (1999) [Pubmed]
  17. Cdx2 specifies the differentiation of morphological as well as functional absorptive enterocytes of the small intestine. Mutoh, H., Satoh, K., Kita, H., Sakamoto, H., Hayakawa, H., Yamamoto, H., Isoda, N., Tamada, K., Ido, K., Sugano, K. Int. J. Dev. Biol. (2005) [Pubmed]
  18. Effects of Taiwanese yam (Dioscorea japonica Thunb var. pseudojaponica Yamamoto) on upper gut function and lipid metabolism in Balb/c mice. Chen, H., Wang, C., Chang, C.T., Wang, T. Nutrition (Burbank, Los Angeles County, Calif.) (2003) [Pubmed]
  19. Potential latentiation forms of biologically active compounds based on action of leucine aminopeptidase. Dipeptide derivatives of the tricycloaliphatic alpha-amino acid, adamantanine. Nagasawa, H.T., Elberling, J.A., Shirota, F.N. J. Med. Chem. (1975) [Pubmed]
  20. Enkephalin analog prodrugs: assessment of in vitro conversion, enzyme cleavage characterization and blood-brain barrier permeability. Greene, D.L., Hau, V.S., Abbruscato, T.J., Bartosz, H., Misicka, A., Lipkowski, A.W., Hom, S., Gillespie, T.J., Hruby, V.J., Davis, T.P. J. Pharmacol. Exp. Ther. (1996) [Pubmed]
  21. Phosphorus-containing peptides as mixed inhibitors of endopeptidase and effect on neurotensin degradation in vitro and in vivo. Vincent, B., Dive, V., Yiotakis, A., Smadja, C., Maldonado, R., Vincent, J.P., Checler, F. Br. J. Pharmacol. (1995) [Pubmed]
  22. Macrophage activation in rat models of inflammation and arthritis: determination of markers of stages of activation. Johnson, W.J., DiMartino, M.J., Hanna, N. Cell. Immunol. (1986) [Pubmed]
  23. Neurotensin and neuromedin N undergo distinct catabolic processes in murine astrocytes and primary cultured neurons. Vincent, B., Vincent, J.P., Checler, F. Eur. J. Biochem. (1994) [Pubmed]
  24. Synteny mapping in the bovine: genes from human chromosome 4. Zhang, N., Threadgill, D.W., Womack, J.E. Genomics (1992) [Pubmed]
  25. Alloimmune interactions of a lymphoproliferative disease-inducer gene Arp and linkage to Pep-7. Matossian-Rogers, A., DeGiorgi, L., Povey, S. Immunogenetics (1983) [Pubmed]
  26. Effect of hydrocortisone on the activity of some lysosomal enzymes in mice. Witek, B., Ochwanowska, E., Slewa, A., Kolataj, A. Neuro Endocrinol. Lett. (2002) [Pubmed]
  27. Nociception, enkephalin content and dipeptidyl carboxypeptidase activity in brain of mice treated with exopeptidase inhibitors. Zhang, A.Z., Yang, H.Y., Costa, E. Neuropharmacology (1982) [Pubmed]
  28. Comparative gene mapping: the linkage relationships of the homologous genes for phosphoglucomutase and peptidase S are conserved in man and mouse. Lalley, P.A., Francke, U., Minna, J.D. Cytogenet. Cell Genet. (1978) [Pubmed]
  29. FACS quantitation of leucine aminopeptidase and acid phosphatase on tumor-associated macrophages from metastatic and nonmetastatic mouse mammary tumors. Mahoney, K.H., Miller, B.E., Heppner, G.H. J. Leukoc. Biol. (1985) [Pubmed]
  30. Partial purification and characterization of neutrophic substance affecting tetrodotoxin sensitivity of organ-cultured mouse muscle. Kuromi, H., Gonoi, T., Hasegawa, S. Brain Res. (1979) [Pubmed]
  31. Purification of a leucine aminopeptidase from Eimeria falciformis. Kaga, M.M., Laurent, F., Doh, A., Luffau, G., Yvoré, P., Péry, P. Vet. Res. (1998) [Pubmed]
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