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Gene Review

LAP3  -  leucine aminopeptidase 3

Homo sapiens

Synonyms: Cytosol aminopeptidase, HEL-S-106, LAP, LAP-3, LAPEP, ...
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Disease relevance of LAP3


Psychiatry related information on LAP3


High impact information on LAP3


Chemical compound and disease context of LAP3


Biological context of LAP3


Anatomical context of LAP3

  • Leucine aminopeptidase was purified from human liver cytosol to homogeneity, 1538-fold, with a yield of 84.4% by immunoaffinity chromatography [19].
  • Degree of confluence, site of biopsy, and sex and age of donor did not affect PEPS activity in fibroblasts but generation number did (r = 0.367, P = 0.001) [16].
  • PEPS activity was measured in white blood cells from three patients with Wolf-Hirschhorn syndrome (4p-) and 50 controls [16].
  • Results are presented supporting assignment of the PEPS locus to chromosome 4 in man using man-mouse and man-Chinese hamster somatic cell hybrids [17].
  • Using exclusion from Sepharose 4B as our criterion, we have found a high-molecular-weight form of alkaline phosphatase and of leucine aminopeptidase which are released into the culture media by the FL amnion cell line [20].

Associations of LAP3 with chemical compounds


Physical interactions of LAP3


Regulatory relationships of LAP3


Other interactions of LAP3


Analytical, diagnostic and therapeutic context of LAP3


  1. Special features of intestinal metaplasia and its relation to early gastric carcinoma in man: observation by a method in which leucine aminopeptidase activity is used. Nakahara, K. J. Natl. Cancer Inst. (1978) [Pubmed]
  2. Hepatic toxicity in the rhesus monkey treated with chenodeoxycholic acid for 6 months: biochemical and ultrastructural studies. Dyrszka, H., Salen, G., Zaki, F.G., Chen, T., Mosbach, E.H. Gastroenterology (1976) [Pubmed]
  3. A bicarbonate ion as a general base in the mechanism of peptide hydrolysis by dizinc leucine aminopeptidase. Sträter, N., Sun, L., Kantrowitz, E.R., Lipscomb, W.N. Proc. Natl. Acad. Sci. U.S.A. (1999) [Pubmed]
  4. Analysis of fetal intestinal enzymes in amniotic fluid for the prenatal diagnosis of cystic fibrosis. Mulivor, R.A., Cook, D., Muller, F., Boué, A., Gilbert, F., Mennuti, M., Pergament, E., Potier, M., Nadler, H., Punnett, H. Am. J. Hum. Genet. (1987) [Pubmed]
  5. Bacterial aminopeptidases: properties and functions. Gonzales, T., Robert-Baudouy, J. FEMS Microbiol. Rev. (1996) [Pubmed]
  6. Action plan peps up Europe's mental health. Walgate, R. Nat. Med. (2005) [Pubmed]
  7. Proteasome and peptidase function in MHC-class-I-mediated antigen presentation. Kloetzel, P.M., Ossendorp, F. Curr. Opin. Immunol. (2004) [Pubmed]
  8. Role of trypsin/creatinine clearance ratio in the differential diagnosis of chronic pancreatic disease. Farini, R., Fabris, C., del Favero, G., Bonvicini, P., de' Best, T., Piccoli, A., Baccaglini, U., Plebani, M., Pedrazzoli, S., Kind, R., Ceriotti, G., Naccarato, R. Gastroenterology (1981) [Pubmed]
  9. Toxicity of chenodeoxycholic acid in the rhesus monkey. Dyrszka, H., Chen, T., Salen, G., Mosbach, E.H. Gastroenterology (1975) [Pubmed]
  10. Aristolochic acids induce chronic renal failure with interstitial fibrosis in salt-depleted rats. Debelle, F.D., Nortier, J.L., De Prez, E.G., Garbar, C.H., Vienne, A.R., Salmon, I.J., Deschodt-Lanckman, M.M., Vanherweghem, J.L. J. Am. Soc. Nephrol. (2002) [Pubmed]
  11. Increased activities of cytosol aminopeptidase and lactate dehydrogenase in serum originate from lymphocytes in necrotizing lymphadenitis. Sugaya, N., Kanno, T., Nirasawa, M., Mitamura, K., Takeuchi, Y., Osano, M. Clin. Chem. (1990) [Pubmed]
  12. Serum levels of secretory immunoglobulin A in liver disease. Fukuda, Y., Imoto, M., Hayakawa, T. Am. J. Gastroenterol. (1985) [Pubmed]
  13. Characterization of ear fluid isolates of Alloiococcus otitidis from patients with recurrent otitis media. Bosley, G.S., Whitney, A.M., Pruckler, J.M., Moss, C.W., Daneshvar, M., Sih, T., Talkington, D.F. J. Clin. Microbiol. (1995) [Pubmed]
  14. Cystine animopeptidase and leucine aminopeptidase of choriocarcinoma cells grown in culture. Ota, T., Chen, C.H., Robinson, J.C. Am. J. Obstet. Gynecol. (1975) [Pubmed]
  15. Differentiation and identification of the two catalytic metal binding sites in bovine lens leucine aminopeptidase by x-ray crystallography. Kim, H., Lipscomb, W.N. Proc. Natl. Acad. Sci. U.S.A. (1993) [Pubmed]
  16. Suggested assignment of peptidase S (PEPS) to 4p11-4q12 by exclusion using gene dosage, accounting for variability in fibroblasts. Schmutz, S.M., Simpson, N.E. Hum. Genet. (1983) [Pubmed]
  17. Assignment of peptidase S (PEPS) to chromosome 4 in man using somatic cell hybrids. Shows, T.B., Brown, J.A., Eddy, R.L., Byers, M.G., Haley, L.L., Cooper, E.S., Goggin, A.P. Hum. Genet. (1978) [Pubmed]
  18. Structural and immunological evidence for the identity of prolyl aminopeptidase with leucyl aminopeptidase. Matsushima, M., Takahashi, T., Ichinose, M., Miki, K., Kurokawa, K., Takahashi, K. Biochem. Biophys. Res. Commun. (1991) [Pubmed]
  19. Immunoaffinity purification and characterization of leucine aminopeptidase from human liver. Kohno, H., Kanda, S., Kanno, T. J. Biol. Chem. (1986) [Pubmed]
  20. The release of high-molecular-weight alkaline phosphatase and leucine aminopeptidase into the media of cultured human cells. Singer, R.M., White, L.J., Perry, J.E., Doellgast, G.J. Cancer Res. (1975) [Pubmed]
  21. General roles of abscisic and jasmonic acids in gene activation as a result of mechanical wounding. Hildmann, T., Ebneth, M., Peña-Cortés, H., Sánchez-Serrano, J.J., Willmitzer, L., Prat, S. Plant Cell (1992) [Pubmed]
  22. Leucine aminopeptidase: bestatin inhibition and a model for enzyme-catalyzed peptide hydrolysis. Burley, S.K., David, P.R., Lipscomb, W.N. Proc. Natl. Acad. Sci. U.S.A. (1991) [Pubmed]
  23. Ethanol-induced oxidative stress suppresses generation of peptides for antigen presentation by hepatoma cells. Osna, N.A., White, R.L., Todero, S., Mc Vicker, B.L., Thiele, G.M., Clemens, D.L., Tuma, D.J., Donohue, T.M. Hepatology (2007) [Pubmed]
  24. Two continuous spectrophotometric assays for methionine aminopeptidase. Zhou, Y., Guo, X.C., Yi, T., Yoshimoto, T., Pei, D. Anal. Biochem. (2000) [Pubmed]
  25. Proteolysis and class I major histocompatibility complex antigen presentation. York, I.A., Goldberg, A.L., Mo, X.Y., Rock, K.L. Immunol. Rev. (1999) [Pubmed]
  26. Synteny mapping in the bovine: genes from human chromosome 4. Zhang, N., Threadgill, D.W., Womack, J.E. Genomics (1992) [Pubmed]
  27. Mapping of a milk production quantitative trait locus to a 420-kb region on bovine chromosome 6. Olsen, H.G., Lien, S., Gautier, M., Nilsen, H., Roseth, A., Berg, P.R., Sundsaasen, K.K., Svendsen, M., Meuwissen, T.H. Genetics (2005) [Pubmed]
  28. Human leukocyte-derived arginine aminopeptidase. The third member of the oxytocinase subfamily of aminopeptidases. Tanioka, T., Hattori, A., Masuda, S., Nomura, Y., Nakayama, H., Mizutani, S., Tsujimoto, M. J. Biol. Chem. (2003) [Pubmed]
  29. Distribution of adipocyte-derived leucine aminopeptidase (A-LAP)/ER-aminopeptidase (ERAP)-1 in human uterine endometrium. Shibata, D., Ando, H., Iwase, A., Nagasaka, T., Hattori, A., Tsujimoto, M., Mizutani, S. J. Histochem. Cytochem. (2004) [Pubmed]
  30. Small intestinal function and structure in patients with chronic renal failure. Arvanitakis, C., Nakos, V., Kalekou-Greka, H., Tourkantonis, A. Clin. Nephrol. (1988) [Pubmed]
  31. epsilon-(gamma-Glutamyl)lysine cross-links in human stratum corneum. Abernethy, J.L., Hill, R.L., Goldsmith, L.A. J. Biol. Chem. (1977) [Pubmed]
  32. Induction of leucine aminopeptidase by interferon-gamma. Identification by protein microsequencing after purification by preparative two-dimensional gel electrophoresis. Harris, C.A., Hunte, B., Krauss, M.R., Taylor, A., Epstein, L.B. J. Biol. Chem. (1992) [Pubmed]
  33. Electron microscopy of leucine aminopeptidase. Kiselev, N.A., Stel'mashchuk, V.Y., Tsuprun, V.L., Ludewig, M., Hanson, H. J. Mol. Biol. (1977) [Pubmed]
  34. High-molecular-mass alkaline phosphatase in serum and bile: nature and relationship with lipoprotein-X. Crofton, P.M., Smith, A.F. Clin. Chem. (1981) [Pubmed]
  35. Prenatal diagnosis of cystic fibrosis: microvillar enzymes and DNA analysis compared. Buffone, G.J., Spence, J.E., Fernbach, S.D., Curry, M.R., O'Brien, W.E., Beaudet, A.L. Clin. Chem. (1988) [Pubmed]
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