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Chemical Compound Review:

Dansylglycine 2-[(5- dimethylaminonaphthalen-1...

Synonyms: DANSYL-GLYCINE, Dns-Gly-OH, CHEMBL343297, SureCN386439, Dansyl glycine, ...

Muller, N. et al., Robertz, G.M. et al., Elbl, G. et al.

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High impact information on NSC 626927

However, the binding site of the fluorescent probe dansylglycine on human serum albumin is not clear from the literature [1].
The binding of dansylglycine to HSA from uremic sera was substantially decreased, reflected mainly by a lower product n1 . K1, as was the binding of dansylglycine to HSA from model sera containing clofibrinic acid [2].

Associations of NSC 626927 with other chemical compounds

The fluorescence of dansylglycine is only extensively changed when ligands of site II are added, suggesting that it strongly interacts with the benzodiazepine/indole binding site on human serum albumin [1].

Analytical, diagnostic and therapeutic context of NSC 626927

The product dansylglycine and unreacted substrate are separated and quantified by reversed phase high performance liquid chromatography with UV detection [3].
Spectrofluorimetric titrations (quenching and complex) and circular dichroism measurements were performed to determine the binding characteristics of dansylglycine to human serum albumin [1].

References

Binding sites of fluorescent probes on human serum albumin. Muller, N., Lapicque, F., Drelon, E., Netter, P. J. Pharm. Pharmacol. (1994) [Pubmed]
Endogenous ligand(s) decrease drug--protein binding in uremic sera: a fluorescence probe study. Robertz, G.M., Dengler, H.J. Klin. Wochenschr. (1983) [Pubmed]
A new method for the in vitro screening of inhibitors of angiotensin-converting enzyme (ACE), using the chromophore- and fluorophore-labelled substrate, dansyltriglycine. Elbl, G., Wagner, H. Planta Med. (1991) [Pubmed]

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