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Chemical Compound Review: 

SureCN545380     4-nitropyridine

Synonyms: AG-D-31271, NSC-30350, QC-1452, AC1L2EQM, NSC30350, ...
 
 
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High impact information on NSC30350

  • The effects of a number of 4-nitroquinoline 1-oxide and 4-nitropyridine 1-oxide derivatives, with varying carcinogenic potencies, on the scission of proteins linking DNA were studied in cultured mouse fibroblasts, strain L-P-3 [1].
  • In the presence of NADH, lipoamide dehydrogenase reduces the nitro group of 4-nitropyridine and 4-nitropyridine N-oxide [2].
  • We have unraveled the effects of an amino substituent in the ortho position on the excited-state dynamics of 4-nitropyridine N-oxide by studying the picosecond fluorescence kinetics and femtosecond transient absorption of a newly synthesized compound, 2-butylamino-6-methyl-4-nitropyridine N-oxide, and by quantum chemical calculations [3].
  • In contrast, all the chemicals tested inhibited rat liver GST activity towards 4-nitropyridine N-oxide, indicating isozyme specificity [4].

References

  1. Breakage of a DNA-protein complex induced by 4-nitroquinoline 1-oxide, 4-nitropyridine 1-oxide, and their derivatives in cultured mouse fibroblasts. Andoh, T., Ide, T., Saito, M., Kawazoe, Y. Cancer Res. (1975) [Pubmed]
  2. Nitroreductase activity of heart lipoamide dehydrogenase. Tsai, C.S. Biochem. J. (1987) [Pubmed]
  3. Femtosecond studies of charge-transfer mediated proton transfer in 2-butylamino-6-methyl-4-nitropyridine N-oxide. Poór, B., Michniewicz, N., Kallay, M., Buma, W.J., Kubinyi, M., Szemik-Hojniak, A., Deperasiñska, I., Puszko, A., Zhang, H. The journal of physical chemistry. A, Molecules, spectroscopy, kinetics, environment & general theory. (2006) [Pubmed]
  4. Inhibition of hepatic glutathione-S-transferases by fatty acids and fatty acid esters. Mitra, A., Govindwar, S., Kulkarni, A.P. Toxicol. Lett. (1991) [Pubmed]
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