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Chemical Compound Review

SureCN538895     4-nitroquinoline

Synonyms: CCRIS 1208, AG-F-31451, SureCN9151559, AC1L2SUM, CTK1C5989, ...
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Disease relevance of CCRIS 1208


High impact information on CCRIS 1208


Chemical compound and disease context of CCRIS 1208


Biological context of CCRIS 1208


Anatomical context of CCRIS 1208

  • The level of mRNAs corresponding to the two groups of cDNAs is increased in the cytoplasm of human epidermal keratinocytes after both UV irradiation and treatment with 4-nitroquinoline 1-oxide or 12-O-tetradecanoylphorbol 13-acetate [20].
  • Here we report the development of an effective colony-forming assay in which a SV40-transformed Werner fibroblast cell line is 6-18-fold more sensitive to 4-nitroquinoline 1-oxide than SV40-transformed normal cell lines [21].
  • Induction of covalent DNA modifications and micronucleated erythrocytes by 4-nitroquinoline 1-oxide in adult and fetal mice [22].
  • The DNA-damaging agent 4-nitroquinoline 1-oxide was applied to NIH-3T3 cells overexpressing normal IGF-IRs (NWTb3 cells) [23].
  • A rat model was used for this purpose, in which dysplasia in the epithelium of the palate was induced by topical application of the carcinogen 4-nitroquinoline 1-oxide [24].

Associations of CCRIS 1208 with other chemical compounds


Gene context of CCRIS 1208


Analytical, diagnostic and therapeutic context of CCRIS 1208


  1. Mucin histochemistry by paradoxical concanavalin A staining in experimental gastric cancers induced in Wistar rats by N-methyl-N-nitro-N-nitrosoguanidine or 4-nitroquinoline 1-oxide. Tatematsu, M., Katsuyama, T., Fukushima, S., Takahashi, M., Shirai, T., Ito, N., Nasu, T. J. Natl. Cancer Inst. (1980) [Pubmed]
  2. Fibroblasts from patients with hereditary cutaneous malignant melanoma are abnormally sensitive to the mutagenic effect of simulated sunlight and 4-nitroquinoline 1-oxide. Howell, J.N., Greene, M.H., Corner, R.C., Maher, V.M., McCormick, J.J. Proc. Natl. Acad. Sci. U.S.A. (1984) [Pubmed]
  3. Specific action of T4 endonuclease V on damaged DNA in xeroderma pigmentosum cells in vivo. Tanaka, K., Hayakawa, H., Sekiguchi, M., Okada, Y. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  4. Chemical transformation of rat cells infected with xenotropic type-C RNA virus and its suppression by virus-specific antiserum. Price, P.J., Suk, W.A., Peters, R.L., Gilden, R.V., Huebner, R.J. Proc. Natl. Acad. Sci. U.S.A. (1977) [Pubmed]
  5. Quantitative trait loci affecting 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in the rat. Tanuma, J., Shisa, H., Hiai, H., Higashi, S., Yamada, Y., Kamoto, T., Hirayama, Y., Matsuuchi, H., Kitano, M. Cancer Res. (1998) [Pubmed]
  6. Induction of unscheduled DNA synthesis in rat stomach mucosa by glandular stomach carcinogens. Furihata, C., Yamawaki, Y., Jin, S.S., Moriya, H., Kodama, K., Matsushima, T., Ishikawa, T., Takayama, S., Nakadate, M. J. Natl. Cancer Inst. (1984) [Pubmed]
  7. Morphologic transformation and chromosomal changes induced by chemical carcinogens in skin fibroblasts from patients with familial adenomatosis coli. Miyaki, M., Akamatsu, N., Ono, T., Tonomura, A., Utsunomiya, J. J. Natl. Cancer Inst. (1982) [Pubmed]
  8. Molecular biology of the carcinogen, 4-nitroquinoline 1-oxide. Nagao, M., Sugimura, T. Adv. Cancer Res. (1976) [Pubmed]
  9. Nonterminal differentiation represses the neoplastic phenotype in spontaneously and simian virus 40-transformed cells. Scott, R.E., Estervig, D.N., Tzen, C.Y., Minoo, P., Maercklein, P.B., Hoerl, B.J. Proc. Natl. Acad. Sci. U.S.A. (1989) [Pubmed]
  10. A yeast excision-repair gene is inducible by DNA damaging agents. Robinson, G.W., Nicolet, C.M., Kalainov, D., Friedberg, E.C. Proc. Natl. Acad. Sci. U.S.A. (1986) [Pubmed]
  11. Sensitivity of subpopulations of mouse skin papillomas to malignant conversion by urethane or 4-nitroquinoline N-oxide. Hennings, H., Shores, R., Balaschak, M., Yuspa, S.H. Cancer Res. (1990) [Pubmed]
  12. Hypersensitivity to cell killing and faulty repair of 1-beta-D-arabinofuranosylcytosine-detectable sites in human (ataxia-telangiectasia) fibroblasts treated with 4-nitroquinoline 1-oxide. Mirzayans, R., Smith, B.P., Paterson, M.C. Cancer Res. (1989) [Pubmed]
  13. Effect of DNA-damaging agents on isolated spleen cells and lung fibroblasts from the mouse mutant "wasted," a putative animal model for ataxia-telangiectasia. Inoue, T., Aikawa, K., Tezuka, H., Kada, T., Shultz, L.D. Cancer Res. (1986) [Pubmed]
  14. Multidrug resistance protein and glutathione S-transferase P1-1 act in synergy to confer protection from 4-nitroquinoline 1-oxide toxicity. Morrow, C.S., Diah, S., Smitherman, P.K., Schneider, E., Townsend, A.J. Carcinogenesis (1998) [Pubmed]
  15. Mutation spectra of the two guanine adducts of the carcinogen 4-nitroquinoline 1-oxide in Escherichia coli. Influence of neighbouring base sequence on mutagenesis. Daubersies, P., Galiègue-Zouitina, S., Koffel-Schwartz, N., Fuchs, R.P., Loucheux-Lefebvre, M.H., Bailleul, B. Carcinogenesis (1992) [Pubmed]
  16. Identification and isolation of the gene encoding the small subunit of ribonucleotide reductase from Saccharomyces cerevisiae: DNA damage-inducible gene required for mitotic viability. Elledge, S.J., Davis, R.W. Mol. Cell. Biol. (1987) [Pubmed]
  17. Detection of in vivo DNA repair synthesis in mouse liver and lung induced by treatment with benzo(a)pyrene or 4-nitroquinoline 1-oxide. Kulkarni, M.S., Angerman-Stewart, J., Anderson, M.W. Cancer Res. (1984) [Pubmed]
  18. A convenient method of establishing permanent lines of xeroderma pigmentosum cells. Tohda, H., Oikawa, A., Katsuki, T., Hinuma, Y., Seiji, M. Cancer Res. (1978) [Pubmed]
  19. Sensitivities of peripheral lymphocytes from healthy humans to induction of sister chromatid exchanges by chemicals. Oikawa, A., Sakai, S., Horaguchi, K., Tohda, H. Cancer Res. (1983) [Pubmed]
  20. Isolation, characterization, and UV-stimulated expression of two families of genes encoding polypeptides of related structure in human epidermal keratinocytes. Kartasova, T., van de Putte, P. Mol. Cell. Biol. (1988) [Pubmed]
  21. WRN or telomerase constructs reverse 4-nitroquinoline 1-oxide sensitivity in transformed Werner syndrome fibroblasts. Hisama, F.M., Chen, Y.H., Meyn, M.S., Oshima, J., Weissman, S.M. Cancer Res. (2000) [Pubmed]
  22. Induction of covalent DNA modifications and micronucleated erythrocytes by 4-nitroquinoline 1-oxide in adult and fetal mice. Lu, L.J., Baxter, J.R., Wang, M.Y., Harper, B.L., Tasaka, F., Kohda, K. Cancer Res. (1990) [Pubmed]
  23. Insulin-like growth factor I induces MDM2-dependent degradation of p53 via the p38 MAPK pathway in response to DNA damage. Héron-Milhavet, L., LeRoith, D. J. Biol. Chem. (2002) [Pubmed]
  24. In vivo detection of dysplastic tissue by Raman spectroscopy. Bakker Schut, T.C., Witjes, M.J., Sterenborg, H.J., Speelman, O.C., Roodenburg, J.L., Marple, E.T., Bruining, H.A., Puppels, G.J. Anal. Chem. (2000) [Pubmed]
  25. Breakage of a DNA-protein complex induced by 4-nitroquinoline 1-oxide, 4-nitropyridine 1-oxide, and their derivatives in cultured mouse fibroblasts. Andoh, T., Ide, T., Saito, M., Kawazoe, Y. Cancer Res. (1975) [Pubmed]
  26. Genetic characterization of adenine-3 mutants induced by 4-nitroquinoline 1-oxide and 4-hydroxyaminoquinoline 1-oxide in Neurospora crassa. Ong, T., Matter, B.E., de Serres, F.J. Cancer Res. (1975) [Pubmed]
  27. Inhibition of DNA replicon initiation by 4-nitroquinoline 1-oxide, adriamycin, and ethyleneimine. Painter, R.B. Cancer Res. (1978) [Pubmed]
  28. Chemoprevention of 4-nitroquinoline 1-oxide-induced rat oral carcinogenesis by the dietary flavonoids chalcone, 2-hydroxychalcone, and quercetin. Makita, H., Tanaka, T., Fujitsuka, H., Tatematsu, N., Satoh, K., Hara, A., Mori, H. Cancer Res. (1996) [Pubmed]
  29. Identification and characterization of SNQ2, a new multidrug ATP binding cassette transporter of the yeast plasma membrane. Decottignies, A., Lambert, L., Catty, P., Degand, H., Epping, E.A., Moye-Rowley, W.S., Balzi, E., Goffeau, A. J. Biol. Chem. (1995) [Pubmed]
  30. Yeast gene YRR1, which is required for resistance to 4-nitroquinoline N-oxide, mediates transcriptional activation of the multidrug resistance transporter gene SNQ2. Cui, Z., Shiraki, T., Hirata, D., Miyakawa, T. Mol. Microbiol. (1998) [Pubmed]
  31. Nucleotide excision repair genes from the yeast Saccharomyces cerevisiae. Friedberg, E.C., Fleer, R., Naumovski, L., Nicolet, C.M., Robinson, G.W., Weiss, W.A., Yang, E. Basic Life Sci. (1986) [Pubmed]
  32. Recovery of a DNA-protein complex in cultured mammalian cells from damage caused by 4-nitroquinoline 1-oxide. Ide, T., Nakane, M., Ando, T. Cancer Res. (1975) [Pubmed]
  33. Enzymatic and nonenzymatic production of free radicals from the carcinogens 4-nitroquinoline N-oxide and 4-hydroxylaminoquinoline N-oxide. Fann, Y.C., Metosh-Dickey, C.A., Winston, G.W., Sygula, A., Rao, D.N., Kadiiska, M.B., Mason, R.P. Chem. Res. Toxicol. (1999) [Pubmed]
  34. Chemopreventive efficacy of all-trans-retinoic acid in biodegradable microspheres against epithelial cancers: results in a 4-nitroquinoline 1-oxide-induced oral carcinogenesis model. Choi, Y., Kim, S.Y., Park, K., Yang, J., Cho, K.J., Kwon, H.J., Byun, Y. International journal of pharmaceutics. (2006) [Pubmed]
  35. Effects of partial hepatectomy on initiation of liver cell foci by 4-nitroquinoline 1-oxide, a non-hepatocarcinogen, and generation of DNA adducts in rats. Tezuka, N., Tada, M., Kojima, M., Nakanishi, H., Mori, A., Tatematsu, M. Cancer Lett. (1995) [Pubmed]
  36. Experimental odontogenic cysts induced by in vitro 4-nitroquinoline 1-oxide (4NQO) treatment of F344 rat incisor tooth germs. Miura, Y., Ozaki, H.S., Li, T.J., Uemura, M., Kitano, M. J. Oral Pathol. Med. (1998) [Pubmed]
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