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Chemical Compound Review:

CTK8G7946 [5-(6-aminopurin-9-yl)-4- hydroxy-2...

Synonyms: AC1L19UW

Jonsson, S. et al., Baetz, A.L. et al., Foulon, V. et al., Ricagno, S. et al., Ricagno, S. et al.

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Disease relevance of formyl-CoA

Kinetic and mechanistic characterization of the formyl-CoA transferase from Oxalobacter formigenes [1].

High impact information on formyl-CoA

We now report the three-dimensional structure of O.formigenes formyl-CoA transferase, which reveals a novel fold and a very striking assembly of the homodimer [2].
In a first step, the 2-hydroxyfatty acid is activated to an acyl-CoA; subsequently, the 2-hydroxy fatty acyl-CoA is cleaved by 2-hydroxyphytanoyl-CoA lyase, to formyl-CoA and an n-1 aldehyde [3].
Further evidence for this mechanistic proposal is provided by the x-ray crystallographic observation of an acylenzyme intermediate that is formed when formyl-CoA transferase is incubated with oxalyl-CoA [1].
Formyl-coenzyme A (formyl-CoA) transferase was purified from Oxalobacter formigenes by high-pressure liquid chromatography with hydrophobic interaction chromatography and by DEAE anion-exchange chromatography [4].

Analytical, diagnostic and therapeutic context of formyl-CoA

Crystallization and preliminary crystallographic analysis of formyl-CoA tranferase from Oxalobacter formigenes [5].

References

Kinetic and mechanistic characterization of the formyl-CoA transferase from Oxalobacter formigenes. Jonsson, S., Ricagno, S., Lindqvist, Y., Richards, N.G. J. Biol. Chem. (2004) [Pubmed]
Formyl-CoA transferase encloses the CoA binding site at the interface of an interlocked dimer. Ricagno, S., Jonsson, S., Richards, N., Lindqvist, Y. EMBO J. (2003) [Pubmed]
Breakdown of 2-hydroxylated straight chain fatty acids via peroxisomal 2-hydroxyphytanoyl-CoA lyase: a revised pathway for the alpha-oxidation of straight chain fatty acids. Foulon, V., Sniekers, M., Huysmans, E., Asselberghs, S., Mahieu, V., Mannaerts, G.P., Van Veldhoven, P.P., Casteels, M. J. Biol. Chem. (2005) [Pubmed]
Purification and characterization of formyl-coenzyme A transferase from Oxalobacter formigenes. Baetz, A.L., Allison, M.J. J. Bacteriol. (1990) [Pubmed]
Crystallization and preliminary crystallographic analysis of formyl-CoA tranferase from Oxalobacter formigenes. Ricagno, S., Jonsson, S., Richards, N., Lindqvist, Y. Acta Crystallogr. D Biol. Crystallogr. (2003) [Pubmed]

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