Gene Review:
SOD1 - superoxide dismutase 1, soluble
Homo sapiens
Synonyms:
ALS, ALS1, HEL-S-44, IPOA, SOD, ...
Ronggen Fu,
Marsee,
Stoeber,
Thomas V. O'Halloran,
Chun,
Thomas Lukas,
Niwa,
Hambrecht,
Kingsbury,
Kibble,
Chen,
Teepu Siddique,
Allen,
Mohammad S. Khan,
Zhang,
Yamanaka,
Dumont,
Maekawa,
O'Halloran,
Fischer,
Borchelt,
Hales,
Paly,
Mauro C. Dal Canto,
Eileen H. Bigio,
Ozanne,
Erdong Liu,
Kojda,
Lalonde,
Eckman,
Hsiao,
Yong Shi,
Leigh,
Carlson,
Yoshiaki Furukawa,
Culotta,
Iadecola,
Sivaprasad,
London,
Turner,
Wu-Yen Hung,
Everall,
Wolfgang,
George H. Gorrie,
Cleveland,
McAlonis-Downes,
Yang,
Williams,
Han-Xiang Deng,
Hong Zhai,
Miller,
Hai,
Younkin,
Al-Sarraj,
Strazielle,
- Amyotrophic lateral sclerosis and structural defects in Cu,Zn superoxide dismutase. Deng, H.X., Hentati, A., Tainer, J.A., Iqbal, Z., Cayabyab, A., Hung, W.Y., Getzoff, E.D., Hu, P., Herzfeldt, B., Roos, R.P. Science (1993)
- The rate and equilibrium constants for a multistep reaction sequence for the aggregation of superoxide dismutase in amyotrophic lateral sclerosis. Khare, S.D., Caplow, M., Dokholyan, N.V. Proc. Natl. Acad. Sci. U.S.A. (2004)
- Immune reactivity in a mouse model of familial ALS correlates with disease progression. Alexianu, M.E., Kozovska, M., Appel, S.H. Neurology (2001)
- Aberrant neuronal and mitochondrial proteins in hippocampus of transgenic mice overexpressing human Cu/Zn superoxide dismutase 1. Shin, J.H., London, J., Le Pecheur, M., Höger, H., Pollak, D., Lubec, G. Free Radic. Biol. Med. (2004)
- Accumulation of human SOD1 and ubiquitinated deposits in the spinal cord of SOD1G93A mice during motor neuron disease progression correlates with a decrease of proteasome. Cheroni, C., Peviani, M., Cascio, P., Debiasi, S., Monti, C., Bendotti, C. Neurobiol. Dis. (2005)
- Conversion to the amyotrophic lateral sclerosis phenotype is associated with intermolecular linked insoluble aggregates of SOD1 in mitochondria. Deng, H.X., Shi, Y., Furukawa, Y., Zhai, H., Fu, R., Liu, E., Gorrie, G.H., Khan, M.S., Hung, W.Y., Bigio, E.H., Lukas, T., Dal Canto, M.C., O'Halloran, T.V., Siddique, T. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Structures of the G85R variant of SOD1 in familial amyotrophic lateral sclerosis. Cao, X., Antonyuk, S.V., Seetharaman, S.V., Whitson, L.J., Taylor, A.B., Holloway, S.P., Strange, R.W., Doucette, P.A., Valentine, J.S., Tiwari, A., Hayward, L.J., Padua, S., Cohlberg, J.A., Hasnain, S.S., Hart, P.J. J. Biol. Chem. (2008)
- Isolated cytochrome c oxidase deficiency in G93A SOD1 mice overexpressing CCS protein. Son, M., Leary, S.C., Romain, N., Pierrel, F., Winge, D.R., Haller, R.G., Elliott, J.L. J. Biol. Chem. (2008)
- Molecular mapping of 21 features associated with partial monosomy 21: involvement of the APP-SOD1 region. Chettouh, Z., Croquette, M.F., Delobel, B., Gilgenkrants, S., Leonard, C., Maunoury, C., Prieur, M., Rethoré, M.O., Sinet, P.M., Chery, M. Am. J. Hum. Genet. (1995)
- Ubiquitin-only intraneuronal inclusion in the substantia nigra is a characteristic feature of motor neurone disease with dementia. Al-Sarraj, S., Maekawa, S., Kibble, M., Everall, I., Leigh, N. Neuropathol. Appl. Neurobiol. (2002)
- Human umbilical cord blood cells ameliorate Alzheimer's disease in transgenic mice. Ende, N., Chen, R., Ende-Harris, D. Journal of medicine. (2001)
- Characterization of hemizygous SOD1/wild-type transgenic mice with the SHIRPA primary screen and tests of sensorimotor function and anxiety. Lalonde, R., Dumont, M., Paly, E., London, J., Strazielle, C. Brain Res. Bull. (2004)
- Copper-zinc superoxide dismutase and amyotrophic lateral sclerosis. Selverstone Valentine, J., Doucette, P.A., Zittin Potter, S. Annu. Rev. Biochem. (2005)
- The retroviral enzymes. Katz, R.A., Skalka, A.M. Annu. Rev. Biochem. (1994)
- X-ray structures of Myc-Max and Mad-Max recognizing DNA. Molecular bases of regulation by proto-oncogenic transcription factors. Nair, S.K., Burley, S.K. Cell (2003)
- A gene encoding a putative GTPase regulator is mutated in familial amyotrophic lateral sclerosis 2. Hadano, S., Hand, C.K., Osuga, H., Yanagisawa, Y., Otomo, A., Devon, R.S., Miyamoto, N., Showguchi-Miyata, J., Okada, Y., Singaraja, R., Figlewicz, D.A., Kwiatkowski, T., Hosler, B.A., Sagie, T., Skaug, J., Nasir, J., Brown, R.H., Scherer, S.W., Rouleau, G.A., Hayden, M.R., Ikeda, J.E. Nat. Genet. (2001)
- Human T cell leukemia virus type 1 oncoprotein Tax targets the human mitotic checkpoint protein MAD1. Jin, D.Y., Spencer, F., Jeang, K.T. Cell (1998)
- Fibrillar inclusions and motor neuron degeneration in transgenic mice expressing superoxide dismutase 1 with a disrupted copper-binding site. Wang, J., Xu, G., Gonzales, V., Coonfield, M., Fromholt, D., Copeland, N.G., Jenkins, N.A., Borchelt, D.R. Neurobiol. Dis. (2002)
- Superoxide dismutase mutations of familial amyotrophic lateral sclerosis and the oxidative inactivation of calcineurin. Volkel, H., Scholz, M., Link, J., Selzle, M., Werner, P., Tunnemann, R., Jung, G., Ludolph, A.C., Reuter, A. FEBS Lett. (2001)
- Overexpression of superoxide dismutase 1 protects against beta-amyloid peptide toxicity: effect of estrogen and copper chelators. Celsi, F., Ferri, A., Casciati, A., D'Ambrosi, N., Rotilio, G., Costa, A., Volonté, C., Carrì, M.T. Neurochem. Int. (2004)
- Impairment of mitochondrial anti-oxidant defence in SOD1-related motor neuron injury and amelioration by ebselen. Wood-Allum, C.A., Barber, S.C., Kirby, J., Heath, P., Holden, H., Mead, R., Higginbottom, A., Allen, S., Beaujeux, T., Alexson, S.E., Ince, P.G., Shaw, P.J. Brain (2006)
- Antioxidative metabolism in Down syndrome. Tekşen, F., Sayli, B.S., Aydin, A., Sayal, A., Işimer, A. Biological trace element research. (1998)
- "Sporadic" motoneuron disease due to familial SOD1 mutation with low penetrance. Suthers, G., Laing, N., Wilton, S., Dorosz, S., Waddy, H. Lancet (1994)
- Amyloid-like filaments and water-filled nanotubes formed by SOD1 mutant proteins linked to familial ALS. Elam, J.S., Taylor, A.B., Strange, R., Antonyuk, S., Doucette, P.A., Rodriguez, J.A., Hasnain, S.S., Hayward, L.J., Valentine, J.S., Yeates, T.O., Hart, P.J. Nat. Struct. Biol. (2003)
- Loss of proliferative capacity and induction of senescence in oxidatively stressed human fibroblasts. Chen, J.H., Stoeber, K., Kingsbury, S., Ozanne, S.E., Williams, G.H., Hales, C.N. J. Biol. Chem. (2004)
- SOD1 rescues cerebral endothelial dysfunction in mice overexpressing amyloid precursor protein. Iadecola, C., Zhang, F., Niwa, K., Eckman, C., Turner, S.K., Fischer, E., Younkin, S., Borchelt, D.R., Hsiao, K.K., Carlson, G.A. Nat. Neurosci. (1999)
- S-nitrosothiol depletion in amyotrophic lateral sclerosis. Schonhoff, C.M., Matsuoka, M., Tummala, H., Johnson, M.A., Estevéz, A.G., Wu, R., Kamaid, A., Ricart, K.C., Hashimoto, Y., Gaston, B., Macdonald, T.L., Xu, Z., Mannick, J.B. Proc. Natl. Acad. Sci. U.S.A. (2006)
- Somatodendritic accumulation of misfolded SOD1-L126Z in motor neurons mediates degeneration: alphaB-crystallin modulates aggregation. Wang, J., Xu, G., Li, H., Gonzales, V., Fromholt, D., Karch, C., Copeland, N.G., Jenkins, N.A., Borchelt, D.R. Hum. Mol. Genet. (2005)
- NEDL1, a novel ubiquitin-protein isopeptide ligase for dishevelled-1, targets mutant superoxide dismutase-1. Miyazaki, K., Fujita, T., Ozaki, T., Kato, C., Kurose, Y., Sakamoto, M., Kato, S., Goto, T., Itoyama, Y., Aoki, M., Nakagawara, A. J. Biol. Chem. (2004)
- Caspase-3 cleaves and inactivates the glutamate transporter EAAT2. Boston-Howes, W., Gibb, S.L., Williams, E.O., Pasinelli, P., Brown, R.H., Trotti, D. J. Biol. Chem. (2006)
- Unsaturated fatty acids induce cytotoxic aggregate formation of amyotrophic lateral sclerosis-linked superoxide dismutase 1 mutants. Kim, Y.J., Nakatomi, R., Akagi, T., Hashikawa, T., Takahashi, R. J. Biol. Chem. (2005)
- The carbonate radical anion-induced covalent aggregation of human copper, zinc superoxide dismutase, and alpha-synuclein: intermediacy of tryptophan- and tyrosine-derived oxidation products. Zhang, H., Andrekopoulos, C., Joseph, J., Crow, J., Kalyanaraman, B. Free Radic. Biol. Med. (2004)
- Modifications of the anti-oxidant metabolism during proliferation and differentiation of colon tumor cell lines. Bravard, A., Beaumatin, J., Dussaulx, E., Lesuffleur, T., Zweibaum, A., Luccioni, C. Int. J. Cancer (1994)
- Lysyl-tRNA synthetase is a target for mutant SOD1 toxicity in mitochondria. Kawamata, H., Magrané, J., Kunst, C., King, M.P., Manfredi, G. J. Biol. Chem. (2008)
- Modifications of superoxide dismutase (SOD1) in human erythrocytes: a possible role in amyotrophic lateral sclerosis. Wilcox, K.C., Zhou, L., Jordon, J.K., Huang, Y., Yu, Y., Redler, R.L., Chen, X., Caplow, M., Dokholyan, N.V. J. Biol. Chem. (2009)
- The neuronal adaptor protein X11alpha interacts with the copper chaperone for SOD1 and regulates SOD1 activity. McLoughlin, D.M., Standen, C.L., Lau, K.F., Ackerley, S., Bartnikas, T.P., Gitlin, J.D., Miller, C.C. J. Biol. Chem. (2001)
- Asymmetric recognition of nonconsensus AP-1 sites by Fos-Jun and Jun-Jun influences transcriptional cooperativity with NFAT1. Ramirez-Carrozzi, V., Kerppola, T. Mol. Cell. Biol. (2003)
- Human p53 binds DNA as a protein homodimer but monomeric variants retain full transcription transactivation activity. Tarunina, M., Jenkins, J.R. Oncogene (1993)
- Commentary on: return of the cycad hypothesis - does the amyotrophic lateral sclerosis/Parkinsonism dementia complex (ALS/PDC) of Guam have new implications for global health? Cox, P.A., Banack, S., Murch, S., Sacks, O. Neuropathol. Appl. Neurobiol. (2006)
- Introduction to the E2F family: protein structure and gene regulation. Slansky, J.E., Farnham, P.J. Curr. Top. Microbiol. Immunol. (1996)
- Activation of superoxide dismutases: putting the metal to the pedal. Culotta, V.C., Yang, M., O'Halloran, T.V. Biochim. Biophys. Acta (2006)
- CD69 in resting and activated T lymphocytes. Its association with a GTP binding protein and biochemical requirements for its expression. Risso, A., Smilovich, D., Capra, M.C., Baldissarro, I., Yan, G., Bargellesi, A., Cosulich, M.E. J. Immunol. (1991)
- N-domain-dependent nonphosphorylated STAT4 dimers required for cytokine-driven activation. Ota, N., Brett, T.J., Murphy, T.L., Fremont, D.H., Murphy, K.M. Nat. Immunol. (2004)
- A loop deletion in the plant acetohydroxy acid isomeroreductase homodimer generates an active monomer with reduced stability and altered magnesium affinity. Wessel, P.M., Biou, V., Douce, R., Dumas, R. Biochemistry (1998)
- Tumor necrosis factor-alpha down-regulates human Cu/Zn superoxide dismutase 1 promoter via JNK/AP-1 signaling pathway. Afonso, V., Santos, G., Collin, P., Khatib, A.M., Mitrovic, D.R., Lomri, N., Leitman, D.C., Lomri, A. Free Radic. Biol. Med. (2006)
- Brain beta-amyloid accumulation in transgenic mice expressing mutant superoxide dismutase 1. Turner, B.J., Li, Q.X., Laughton, K.M., Masters, C.L., Lopes, E.C., Atkin, J.D., Cheema, S.S. Neurochem. Res. (2004)
- Hsp70 and Hsp40 improve neurite outgrowth and suppress intracytoplasmic aggregate formation in cultured neuronal cells expressing mutant SOD1. Takeuchi, H., Kobayashi, Y., Yoshihara, T., Niwa, J., Doyu, M., Ohtsuka, K., Sobue, G. Brain Res. (2002)
- ATF3 and stress responses. Hai, T., Wolfgang, C.D., Marsee, D.K., Allen, A.E., Sivaprasad, U. Gene Expr. (1999)
- Modulation of the transcriptional activity of thyroid hormone receptors by the tumor suppressor p53. Yap, N., Yu, C.L., Cheng, S.Y. Proc. Natl. Acad. Sci. U.S.A. (1996)
- Progressive spinal axonal degeneration and slowness in ALS2-deficient mice. Yamanaka, K., Miller, T.M., McAlonis-Downes, M., Chun, S.J., Cleveland, D.W. Ann. Neurol. (2006)
- S100A6 overexpression within astrocytes associated with impaired axons from both ALS mouse model and human patients. Hoyaux, D., Boom, A., Van den Bosch, L., Belot, N., Martin, J.J., Heizmann, C.W., Kiss, R., Pochet, R. J. Neuropathol. Exp. Neurol. (2002)
- SOD2: a new type of tumor-suppressor gene? Bravard, A., Sabatier, L., Hoffschir, F., Ricoul, M., Luccioni, C., Dutrillaux, B. Int. J. Cancer (1992)
- Molecular mechanisms of vascular adaptations to exercise. Physical activity as an effective antioxidant therapy? Kojda, G., Hambrecht, R. Cardiovasc. Res. (2005)
- Peroxiredoxin 2 (PRDX2), an antioxidant enzyme, is under-expressed in Down syndrome fetal brains. Sánchez-Font, M.F., Sebastià, J., Sanfeliu, C., Cristòfol, R., Marfany, G., Gonzàlez-Duarte, R. Cell. Mol. Life Sci. (2003)
- GDNF delivery using human neural progenitor cells in a rat model of ALS. Klein, S.M., Behrstock, S., McHugh, J., Hoffmann, K., Wallace, K., Suzuki, M., Aebischer, P., Svendsen, C.N. Hum. Gene Ther. (2005)
- Cerebral neurons of transgenic ALS mice are vulnerable to glutamate release stimulation but not to increased extracellular glutamate due to transport blockade. Tovar-y-Romo, L.B., Tapia, R. Exp. Neurol. (2006)