Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Resivit 2-(3,4- dihydroxyphenyl)chroman- 3,4,5,7-tetrol

Synonyms: Procyanidol, Leucocianidol, Leucocyanidin, Leucocyanidol, Leukocyanidine, ...

Andriambeloson, E. et al., Kristiansen, K.N. et al.

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High impact information on Leucoanthocyanidol

7. Electron paramagnetic resonance (e.p.r.) spectroscopy studies with Fe(2+)-diethyldithiocarbamate as an NO spin trap demonstrated that RWPC and leucocyanidol increased NO levels in rat thoracic aorta about 2 fold [1].
5. In contrast to superoxide dismutase (SOD, 100 u ml-1), neither RWPC nor leucocyanidol affected the concentration-response curve for the NO donor, SIN-1 (3-morpholino-sydnonimine) which also produces superoxide anion (O2-) [1].
In vitro transcription and translation of the Hordeum vulgare cDNA clone yielded a protein which converts dihydroquercetin into 2,3-trans-3,4-cis-leucocyanidin with NADPH as cofactor [2].

References

Nitric oxide production and endothelium-dependent vasorelaxation induced by wine polyphenols in rat aorta. Andriambeloson, E., Kleschyov, A.L., Muller, B., Beretz, A., Stoclet, J.C., Andriantsitohaina, R. Br. J. Pharmacol. (1997) [Pubmed]
Structure of the Hordeum vulgare gene encoding dihydroflavonol-4-reductase and molecular analysis of ant18 mutants blocked in flavonoid synthesis. Kristiansen, K.N., Rohde, W. Mol. Gen. Genet. (1991) [Pubmed]

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