The world's first wiki where authorship really matters (Nature Genetics, 2008). Due credit and reputation for authors. Imagine a global collaborative knowledge base for original thoughts. Search thousands of articles and collaborate with scientists around the globe.

wikigene or wiki gene protein drug chemical gene disease author authorship tracking collaborative publishing evolutionary knowledge reputation system wiki2.0 global collaboration genes proteins drugs chemicals diseases compound
Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)
MeSH Review

Aorta, Thoracic

Welcome! If you are familiar with the subject of this article, you can contribute to this open access knowledge base by deleting incorrect information, restructuring or completely rewriting any text. Read more.

Disease relevance of Aorta, Thoracic


Psychiatry related information on Aorta, Thoracic

  • Transmission electron microscopy of the media of the thoracic aorta revealed that the types of intercellular contacts seen in the controls and in the BAPN group were intermediate junctions (IJs), nexus junctions (NJs), simple appositions (SAs), and interdigitations (Ids) as in adult vessels [6].

High impact information on Aorta, Thoracic


Chemical compound and disease context of Aorta, Thoracic


Biological context of Aorta, Thoracic


Anatomical context of Aorta, Thoracic


Associations of Aorta, Thoracic with chemical compounds

  • After 28 d of dietary treatment, segments of thoracic aorta from the 0.5 and 1% cholesterol groups demonstrated impairment of acetylcholine-mediated endothelium-dependent arterial relaxation compared to chow-fed animals (57 +/- 11% and 45 +/- 9% vs 78 +/- 3%, respectively; P < 0.05) [27].
  • We have examined, using quantitative autoradiography, the expression of angiotensin II receptor subtypes AT1 and AT2, and angiotensin-converting enzyme, in the neointima formed in the rat thoracic aorta 15 d after balloon-catheter injury [28].
  • Using cultured SMC from rabbit thoracic aorta, we demonstrated that PGI2, 6-keto-PGF1 alpha, and 6-keto-PGE1 enhanced ACEH activity fourfold [29].
  • We report here that human recombinant IL-1-beta potently inhibits the response of rat thoracic aorta to vasoconstrictor agents [30].
  • After 3 mo of enalapril treatment (10 mg/kg per d, p.o.) the percent plaque areas in the thoracic aortas of treated animals were significantly reduced (controls: 86.8 +/- 3.5%; treated: 31.1 +/- 8%, P < 0.001) [31].

Gene context of Aorta, Thoracic


Analytical, diagnostic and therapeutic context of Aorta, Thoracic


  1. Tbx1 haploinsufficieny in the DiGeorge syndrome region causes aortic arch defects in mice. Lindsay, E.A., Vitelli, F., Su, H., Morishima, M., Huynh, T., Pramparo, T., Jurecic, V., Ogunrinu, G., Sutherland, H.F., Scambler, P.J., Bradley, A., Baldini, A. Nature (2001) [Pubmed]
  2. Aortic distensibility in patients with isolated hypercholesterolaemia, coronary artery disease, or cardiac transplant. Dart, A.M., Lacombe, F., Yeoh, J.K., Cameron, J.D., Jennings, G.L., Laufer, E., Esmore, D.S. Lancet (1991) [Pubmed]
  3. Reappraisal of the mechanism for cerebrospinal fluid hypertension during aortic surgery. Spence, P.A., Lust, R.M., Iida, H., Sun, Y.S., Austin, E.H., Chitwood, W.R. Circulation (1990) [Pubmed]
  4. Simultaneous aortic, jugular bulb, and right atrial pressures during cardiopulmonary resuscitation in humans. Insights into mechanisms. Paradis, N.A., Martin, G.B., Goetting, M.G., Rosenberg, J.M., Rivers, E.P., Appleton, T.J., Nowak, R.M. Circulation (1989) [Pubmed]
  5. The atherogenic effect of excess methionine intake. Troen, A.M., Lutgens, E., Smith, D.E., Rosenberg, I.H., Selhub, J. Proc. Natl. Acad. Sci. U.S.A. (2003) [Pubmed]
  6. Intercellular contacts in the media of the thoracic aorta of rat fetuses treated with beta-aminopropionitrile. Sosa-Melgarejo, J.A., Berry, C.L. J. Pathol. (1991) [Pubmed]
  7. Cited2 controls left-right patterning and heart development through a Nodal-Pitx2c pathway. Bamforth, S.D., Bragança, J., Farthing, C.R., Schneider, J.E., Broadbent, C., Michell, A.C., Clarke, K., Neubauer, S., Norris, D., Brown, N.A., Anderson, R.H., Bhattacharya, S. Nat. Genet. (2004) [Pubmed]
  8. Formalin infiltration of the ductus arteriosus. A method for palliation of infants with selected congenital cardiac lesions. Rudolph, A.M., Heymann, M.A., Fishman, N., Lakier, J.B. N. Engl. J. Med. (1975) [Pubmed]
  9. Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation. Rapoport, R.M., Draznin, M.B., Murad, F. Nature (1983) [Pubmed]
  10. Tbx1 is regulated by tissue-specific forkhead proteins through a common Sonic hedgehog-responsive enhancer. Yamagishi, H., Maeda, J., Hu, T., McAnally, J., Conway, S.J., Kume, T., Meyers, E.N., Yamagishi, C., Srivastava, D. Genes Dev. (2003) [Pubmed]
  11. Calcification of the aortic arch: risk factors and association with coronary heart disease, stroke, and peripheral vascular disease. Iribarren, C., Sidney, S., Sternfeld, B., Browner, W.S. JAMA (2000) [Pubmed]
  12. Effect of hypercholesterolemia on vascular reactivity in the rabbit. I. Endothelium-dependent and endothelium-independent contractions and relaxations in isolated arteries of control and hypercholesterolemic rabbits. Verbeuren, T.J., Jordaens, F.H., Zonnekeyn, L.L., Van Hove, C.E., Coene, M.C., Herman, A.G. Circ. Res. (1986) [Pubmed]
  13. Paradoxically decreased aortic wall stiffness in response to vitamin D3-induced calcinosis. A biphasic analysis of segmental elastic properties in conscious dogs. Cabrera Fischer, E.I., Armentano, R.L., Levenson, J., Barra, J.G., Morales, M.C., Breitbart, G.J., Pichel, R.H., Simon, A. Circ. Res. (1991) [Pubmed]
  14. A comparative study of morphological changes in spontaneously hypertensive rats and normotensive Wistar Kyoto rats treated with an angiotensin-converting enzyme inhibitor or a calcium-channel blocker. Saleh, F.H., Jurjus, A.R. J. Pathol. (2001) [Pubmed]
  15. Inhibition of hypercholesterolemia-induced atherosclerosis in the nonhuman primate by probucol. II. Cellular composition and proliferation. Chang, M.Y., Sasahara, M., Chait, A., Raines, E.W., Ross, R. Arterioscler. Thromb. Vasc. Biol. (1995) [Pubmed]
  16. Effects of hypoxia upon contractions evoked in isolated rabbit pulmonary artery by potassium and noradrenaline. Marriott, J.F., Marshall, J.M. J. Physiol. (Lond.) (1990) [Pubmed]
  17. Aortic arch malformations and ventricular septal defect in mice deficient in endothelin-1. Kurihara, Y., Kurihara, H., Oda, H., Maemura, K., Nagai, R., Ishikawa, T., Yazaki, Y. J. Clin. Invest. (1995) [Pubmed]
  18. Cross-clamping the thoracic aorta. Effect on intracranial pressure. D'Ambra, M.N., Dewhirst, W., Jacobs, M., Bergus, B., Borges, L., Hilgenberg, A. Circulation (1988) [Pubmed]
  19. Subaortic fibrous ridge and ventricular septal defect: role of septal malalignment. Zielinsky, P., Rossi, M., Haertel, J.C., Vitola, D., Lucchese, F.A., Rodrigues, R. Circulation (1987) [Pubmed]
  20. Knockout of the alpha 1A/C-adrenergic receptor subtype: the alpha 1A/C is expressed in resistance arteries and is required to maintain arterial blood pressure. Rokosh, D.G., Simpson, P.C. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  21. Nonlinear summation of depressor effects of carotid sinus pressure changes and aortic nerve stimulation in the rabbit. Ishikawa, N., Sagawa, K. Circ. Res. (1983) [Pubmed]
  22. PPARalpha deficiency reduces insulin resistance and atherosclerosis in apoE-null mice. Tordjman, K., Bernal-Mizrachi, C., Zemany, L., Weng, S., Feng, C., Zhang, F., Leone, T.C., Coleman, T., Kelly, D.P., Semenkovich, C.F. J. Clin. Invest. (2001) [Pubmed]
  23. Ets-1 is a critical regulator of Ang II-mediated vascular inflammation and remodeling. Zhan, Y., Brown, C., Maynard, E., Anshelevich, A., Ni, W., Ho, I.C., Oettgen, P. J. Clin. Invest. (2005) [Pubmed]
  24. Role of Endothelin-1/Endothelin-A receptor-mediated signaling pathway in the aortic arch patterning in mice. Yanagisawa, H., Hammer, R.E., Richardson, J.A., Williams, S.C., Clouthier, D.E., Yanagisawa, M. J. Clin. Invest. (1998) [Pubmed]
  25. Association and cosegregation of stroke with impaired endothelium-dependent vasorelaxation in stroke prone, spontaneously hypertensive rats. Volpe, M., Iaccarino, G., Vecchione, C., Rizzoni, D., Russo, R., Rubattu, S., Condorelli, G., Ganten, U., Ganten, D., Trimarco, B., Lindpaintner, K. J. Clin. Invest. (1996) [Pubmed]
  26. Nitrolinoleate, a nitric oxide-derived mediator of cell function: synthesis, characterization, and vasomotor activity. Lim, D.G., Sweeney, S., Bloodsworth, A., White, C.R., Chumley, P.H., Krishna, N.R., Schopfer, F., O'Donnell, V.B., Eiserich, J.P., Freeman, B.A. Proc. Natl. Acad. Sci. U.S.A. (2002) [Pubmed]
  27. Dietary probucol preserves endothelial function in cholesterol-fed rabbits by limiting vascular oxidative stress and superoxide generation. Keaney, J.F., Xu, A., Cunningham, D., Jackson, T., Frei, B., Vita, J.A. J. Clin. Invest. (1995) [Pubmed]
  28. Balloon angioplasty enhances the expression of angiotensin II AT1 receptors in neointima of rat aorta. Viswanathan, M., Strömberg, C., Seltzer, A., Saavedra, J.M. J. Clin. Invest. (1992) [Pubmed]
  29. Prostacyclin modulates cholesteryl ester hydrolytic activity by its effect on cyclic adenosine monophosphate in rabbit aortic smooth muscle cells. Hajjar, D.P., Weksler, B.B., Falcone, D.J., Hefton, J.M., Tack-Goldman, K., Minick, C.R. J. Clin. Invest. (1982) [Pubmed]
  30. Interleukin 1 inhibits contraction of vascular smooth muscle. Beasley, D., Cohen, R.A., Levinsky, N.G. J. Clin. Invest. (1989) [Pubmed]
  31. Differential effects of renin-angiotensin system blockade on atherogenesis in cholesterol-fed rabbits. Schuh, J.R., Blehm, D.J., Frierdich, G.E., McMahon, E.G., Blaine, E.H. J. Clin. Invest. (1993) [Pubmed]
  32. A genetic link between Tbx1 and fibroblast growth factor signaling. Vitelli, F., Taddei, I., Morishima, M., Meyers, E.N., Lindsay, E.A., Baldini, A. Development (2002) [Pubmed]
  33. Vascular expression of polycystin-2. Torres, V.E., Cai, Y., Chen, X., Wu, G.Q., Geng, L., Cleghorn, K.A., Johnson, C.M., Somlo, S. J. Am. Soc. Nephrol. (2001) [Pubmed]
  34. Roles for the winged helix transcription factors MF1 and MFH1 in cardiovascular development revealed by nonallelic noncomplementation of null alleles. Winnier, G.E., Kume, T., Deng, K., Rogers, R., Bundy, J., Raines, C., Walter, M.A., Hogan, B.L., Conway, S.J. Dev. Biol. (1999) [Pubmed]
  35. Receptors mediating CGRP-induced relaxation in the rat isolated thoracic aorta and porcine isolated coronary artery differentiated by h(alpha) CGRP(8-37). Wisskirchen, F.M., Gray, D.W., Marshall, I. Br. J. Pharmacol. (1999) [Pubmed]
  36. Arterial osteoprotegerin: increased amounts in diabetes and modifiable synthesis from vascular smooth muscle cells by insulin and TNF-alpha. Olesen, P., Ledet, T., Rasmussen, L.M. Diabetologia (2005) [Pubmed]
  37. Trandolapril inhibits atherosclerosis in the Watanabe heritable hyperlipidemic rabbit. Chobanian, A.V., Haudenschild, C.C., Nickerson, C., Hope, S. Hypertension (1992) [Pubmed]
  38. Parthenolide, an inhibitor of the nuclear factor-kappaB pathway, ameliorates cardiovascular derangement and outcome in endotoxic shock in rodents. Sheehan, M., Wong, H.R., Hake, P.W., Malhotra, V., O'Connor, M., Zingarelli, B. Mol. Pharmacol. (2002) [Pubmed]
  39. Prenatal diagnosis by FISH of a 22q11 deletion in two families. Portnoï, M.F., Joyé, N., Gonzales, M., Demczuk, S., Fermont, L., Gaillard, G., Bercau, G., Morlier, G., Taillemite, J.L. J. Med. Genet. (1998) [Pubmed]
  40. Alterations in plasma endothelin during passage through the left heart chambers before and after brief myocardial ischaemia. Tønnessen, T., Naess, P.A., Kirkebøen, K.A., Ilebekk, A., Christensen, G. Cardiovasc. Res. (1993) [Pubmed]
WikiGenes - Universities