Hoffmann, R. A wiki for the life sciences where authorship matters. Nature Genetics (2008)

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Chemical Compound Review:

Fenleuton 1-[4-[3-(4- fluorophenoxy)phenyl]but-3- yn-2...

Synonyms: LoFrin, ABBOTT-76745, Lofrin (TN), CHEMBL293743, AG-J-83034, ...

Marr, K.A. et al., Marr, K. et al.

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Disease relevance of LoFrin

To further investigate the role of these putative mediators in the pathogenesis of equine COPD the effect of a 5-lipoxygenase inhibitor, fenleuton, on antigen-induced changes in horses with this condition has been examined [1].

High impact information on LoFrin

Pharmacokinetics and pharmacodynamics of fenleuton, a 5-lipoxygenase inhibitor, in ponies [2].
Effect of the 5-lipoxygenase inhibitor, fenleuton, on antigen-induced neutrophil accumulation and lung function changes in horses with chronic obstructive pulmonary disease [1].
Orally administered fenleuton (four 5 mg kg(-1) doses, given once daily) was absorbed from the gastrointestinal tract, and penetrated readily into tissue cage exudate, the ratio of the plasma:exudate AUC0-48h being 0.90+/-0.02 (n=6) [2].

References

Effect of the 5-lipoxygenase inhibitor, fenleuton, on antigen-induced neutrophil accumulation and lung function changes in horses with chronic obstructive pulmonary disease. Marr, K.A., Lees, P., Page, C.P., Cunningham, F.M. J. Vet. Pharmacol. Ther. (1998) [Pubmed]
Pharmacokinetics and pharmacodynamics of fenleuton, a 5-lipoxygenase inhibitor, in ponies. Marr, K., Marsh, K., Hernandez, L., Cunningham, F.M., Lees, P. Res. Vet. Sci. (1998) [Pubmed]

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